Holistic Health Herbal Medicine The Health Benefits of Huperzine A By Cathy Wong facebook twitter Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Learn about our editorial process Cathy Wong Medically reviewed by Medically reviewed by Arno Kroner, DAOM, LAc on August 10, 2020 facebook twitter linkedin Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, as well as an herbalist and integrative medicine doctor. He operates a private practice in Santa Monica, California. Learn about our Medical Review Board Arno Kroner, DAOM, LAc on August 10, 2020 Print Verywell / Anastasia Tretiak Table of Contents View All Table of Contents Health Benefits Possible Side Effects Dosage and Preparations What To Look For Other Questions Huperzine A is a substance extracted from a plant called Chinese club moss (Huperzia serrata). Sold as a dietary supplement, huperzine A is typically touted as a treatment for Alzheimer's disease. Used in alternative medicine, huperzine A has been found to act as a cholinesterase inhibitor, a type of medicine used to prevent the breakdown of acetylcholine (a chemical essential to learning and memory). Not only used as a treatment for Alzheimer's disease, huperzine A is also said to enhance learning and memory and to protect against age-related cognitive decline. In addition, huperzine A is sometimes used to boost energy, increase alertness, fight depression, and aid in the treatment of myasthenia gravis, an autoimmune disorder that affects the muscles. However, the research is limited. Commonly Known As Huperzine ASelagine Health Benefits While research on the health effects of huperzine A is limited, there's some evidence that huperzine A may offer certain benefits. Here's a look at some key findings from the available research: Alzheimer's Disease Huperzine A appears to be of some benefit to people with Alzheimer's disease, according to a 2013 research review published in PLoS One. Researchers searched for all randomized controlled trials on the efficacy and safety of huperzine A for Alzheimer's disease and concluded that huperzine A was more effective than a placebo in terms of its effects on cognitive function, behavioral disturbance, and functional performance. This was also found in a 2008 review published in Cochrane Database of Systematic Reviews. However, a 2011 study published in Neurology showed huperzine A failed to improve cognitive function in Alzheimer's patients. The study involved 210 people with mild to moderate Alzheimer's disease, each of whom received either huperzine A or a placebo for at least 16 weeks. In their analysis of the 177 participants who completed the study, researchers found that huperzine A did not have a significant effect on cognitive function. Memory Enhancement Very few studies have tested the use of huperzine A for memory enhancement. However, an older, small study published in the Chinese journal Acta Pharmacologica Sinica in 1999 found that huperzine A helped improve memory and learning in a group of adolescent students. For the study, 68 junior high students (all of whom complained of memory inadequacy) were given either huperzine A or a placebo every day for four weeks. By the study's end, members of the huperzine A group showed greater improvements in learning and memory (compared to members of the placebo group). More research is needed before huperzine A can be recommended for memory enhancement. Possible Side Effects Huperzine A may cause side effects including nausea, diarrhea, vomiting, dry mouth, constipation, sweating, blurred vision, slurred speech, fainting, restlessness, loss of appetite, contraction and twitching of muscle fibers, cramping, increased saliva and urine, inability to control urination, high blood pressure, swelling, dizziness, inability to sleep, and slowed heart rate. Little is known about the safety of taking huperzine A in the long term. There is some concern that the use of huperzine A may be harmful to people with certain health conditions, including kidney and/or liver disorders, heart disease, asthma, epilepsy, and vertigo. Interactions Huperzine A may interact with certain medications including cholinesterase inhibitors, beta-blockers, and anti-convulsive agents. Given these safety concerns, it's important to consult your physician if you're considering the use of huperzine A. Dosage and Preparations Huperzine A comes in tablets and capsules, and is an added ingredient in several combination supplements touted as memory enhancers. There is no recommended daily allowance for huperzine A. The following doses have been studied: Alzheimer's disease: 300 mcg to 500 mcg dailyDementia: 100 mcg twice dailyMemory booster: 100 mcg twice daily What To Look For When selecting a brand of supplements, look for products that have been certified by Consumer Labs, The U.S. Pharmacopeial Convention, or NSF International. Other Questions Does huperzine A raise blood pressure? Huperzine A may raise heart rate, and therefore may raise blood pressure. If you have hypertension, speak to your doctor before taking huperzine A. Will huperzine A improve my workout? Huperzine A is used in bodybuilding as a nootropic, meaning it boosts focus. It is touted as a workout enhancer and included in several combination supplements. However, there is not enough supporting evidence to support this use. A Word From Verywell Due to a lack of supporting research, huperzine A cannot currently be recommended for treatment or prevention of any health problem. If you're considering the use of huperzine A supplements, consult your doctor before starting your supplement regime to weigh the risks, benefits, and appropriateness. It's important to note that self-treating Alzheimer's disease (or any other condition) with huperzine A and avoiding or delaying standard care may have serious health consequences. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Xing SH, Zhu CX, Zhang R, An L. Huperzine A in the treatment of Alzheimer's disease and vascular dementia: A meta-analysis. Evid Based Complement Alternat Med. 2014;2014:363985. doi:10.1155/2014/363985 Yang G, Wang Y, Tian J, Liu JP. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. PLoS One. 2013;8(9):e74916. doi:10.1371/journal.pone.0074916 Li J, Wu HM, Zhou RL, et al. Huperzine A for Alzheimer's disease. Cochrane Database Syst Rev. 2008;(2):CD005592. doi:10.1002/14651858.CD005592.pub2 Rafii MS, Walsh S, Little JT, et al; Alzheimer's Disease Cooperative Study. A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology. 2011;76(16):1389-94. doi:10.1212/WNL.0b013e318216eb7b Sun QQ, Xu SS, et al. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Zhongguo Yao Li Xue Bao. 1999;20(7):601-3. Zhang HY. New insights into huperzine A for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2012;33(9):1170–1175. doi:10.1038/aps.2012.128