The Health Benefits of MSM

A Sulfur Rich Supplement That May Provide Pain Relief

Methylsulfonylmethane (MSM) is a chemical found naturally in cow's milk and in a variety of foods, including some types of meat, seafood, fruits, and vegetables. MSM is also sold in dietary supplement form. Some believe that the substance can treat a wide range of health problems, most notably arthritis.

MSM contains sulfur, a chemical element known to play a role in many biological processes. Proponents suggest that increasing your intake of sulfur can improve your health, in part by fighting chronic inflammation.

Health Benefits

Methylsulfonylmethane became popular in 1999 after the publication of a book that promoted the supplement's pain relief benefits. The book's author claimed that MSM was the first safe, natural, side-effect-free remedy for many types of pain and inflammatory conditions. There is very little scientific evidence, however, supporting these claims. Studies investigating the effects of MSM are limited.


There is limited scientific support for MSM's effectiveness as an osteoarthritis treatment.

For a research review published in the journal Osteoarthritis and Cartilage in 2008, scientists looked at six previously published studies testing the use of MSM or dimethyl sulfoxide (another sulfur-containing compound) among people with osteoarthritis of the knee.

Analyzing the findings from the two trials focusing on MSM, the review authors found "positive but not definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee." The authors called for further research to identify the optimum dosage of MSM and to determine whether MSM is safe for long-term use.

Another study published in BMC Complementary and Alternative Medicine in 2011, involved 49 men and women with osteoarthritis of the knee. Researchers demonstrated those treated with MSM supplements for 12 weeks experienced a significantly greater improvement in physical function in comparison to those given a placebo for the same time period. However, the two study groups did not differ significantly in measures of pain and stiffness.

osteoarthritis knee pain
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Topical use of MSM shows promise in the treatment of rosacea, according to a small study published in the Journal of Cosmetic Dermatology in 2008. For the study, 46 patients with rosacea were treated with either a placebo or a combination of MSM and silymarin (a compound extracted from milk thistle). At the study's end, those treated with the MSM/silymarin combination showed greater improvement in symptoms like skin redness and itching. However, it is unclear if it was the MSM, the milk thistle or the combination that provided the benefit.


A small study published in the Journal of Alternative and Complementary Medicine in 2002 suggests that MSM may be of some benefit in the treatment of seasonal allergies.

After 30 days of taking MSM daily, study members had a significant reduction in allergy-related respiratory symptoms. Involving a total of 55 people with seasonal allergies (50 of whom ended up completing the study), the study also found that treatment with MSM improved participants' energy levels.


In a small study published in Updates in Surgery in 2012, a topical gel containing a combination of MSM, hyaluronic acid, and tea tree oil was found to reduce symptoms such as pain, bleeding, inflammation, and irritation. The study involved 36 patients and a 14-day treatment period. But again, it is not clear which ingredient provided the benefit or if it was the combination of ingredients that were beneficial.

In addition to the above uses, MSM is also used as a natural remedy for the following conditions:

MSM is also said to promote weight loss, stimulate circulation, boost the immune system, enhance mood, improve sports performance, and protect against some forms of cancer.

When applied directly to the skin, MSM is purported to reverse signs of aging and treat skin conditions such as rosacea.

According to the National Institutes of Health (NIH) and other sources, there is not enough scientific evidence to support these uses.

Possible Side Effects

MSM may trigger a number of side effects, such as stomach upset, headache, insomnia, and diarrhea. But according to the NIH, the supplement is possibly safe for most people when taken by mouth for up to three months.

When applied to the skin MSM is possibly safe in combination with other ingredients, such as silymarin or hyaluronic acid and tea tree oil, for up to 20 days. But applying a lotion that contains MSM to the lower limbs can increase swelling and pain in people with varicose veins and other circulatory problems.

Since little is known about the safety of long-term or regular use of MSM, it's important to consult your physician prior to taking MSM.

Women who are pregnant or breastfeeding should avoid MSM as there is not enough evidence to know if it is safe.

Dosage and Preparation

There is no recommended dose or Recommended Dietary Allowance (RDA) for MSM or sulfur, which is in MSM. Sulfur deficiency in humans is very rare.

Various doses of MSM have been used in research investigating its potential benefits.

For example, in a study investigating the use of MSM for osteoarthritis, a dose of 1.5 to six grams of MSM was taken daily in up to three divided doses for up to 12 weeks. Another study used five grams of MSM plus 7.2 mg of boswellic acid taken daily for 60 days.

In studies investigating the supplement's benefits in the treatment of hemorrhoids, a specific gel containing hyaluronic acid, tea tree oil, and MSM was applied daily for 14 days.

What to Look For

MSM supplements are sold in many drugstores, as well as in stores specializing in natural products. You can also purchase MSM supplements online. These products are sold in crystal, powder, or capsule form. Some contain other ingredients such as glucosamine.

If you are considering a product such as MSM for health benefits or to manage a condition, keep in mind that dietary supplements are largely unregulated by the FDA. It is illegal to make marketing claims (on the product label or in advertisements) that promote a dietary supplement as a treatment or cure for a specific disease or to alleviate the symptoms of a disease.

To stay on the safe side, it's best to look for products that have been certified by ConsumerLabs, The U.S. Pharmacopeial Convention, or NSF International. These organizations don't guarantee that a product is safe or effective, but they do provide a certain level of testing for quality.

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  2. Debbi EM, Agar G, Fichman G, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. doi:10.1186/1472-6882-11-50

  3. Berardesca E, Cameli N, Cavallotti C, Levy JL, Piérard GE, De paoli ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008;7(1):8-14. doi:10.1111/j.1473-2165.2008.00355.x

  4. Barrager E, Veltmann JR, Schauss AG, Schiller RN. A multicentered, open-label trial on the safety and efficacy of methylsulfonylmethane in the treatment of seasonal allergic rhinitis. J Altern Complement Med. 2002;8(2):167-73. doi: 10.1089/107555302317371451

  5. Joksimovic N, Spasovski G, Joksimovic V, Andreevski V, Zuccari C, Omini CF. Efficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trial. Updates Surg. 2012;64(3):195-201. doi:10.1007/s13304-012-0153-4

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