The Health Benefits of Poria Mushrooms

Purported to boost immunity and offer other benefits

Poria tablets, capsules, dried mushroom, granules and powder

Verywell / Anastasia Tretiak

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Poria (Poria cocos) is a type of mushroom. It's been used for 2,000 years in traditional Chinese medicine (TCM). Next to licorice root, it's one of the most commonly prescribed traditional remedies in China.

Poria has caught the attention of researchers. It shows promise as a treatment for cancer, Alzheimer's disease, and much more.

The medicinal part of the mushroom is the filaments under the cap. You can buy poria dried or in capsule form.

In this article, you'll learn what poria's being studied for, what's known about it as a treatment, what side effects and risks are possible, typical dosages, how to prepare it, and what to look for in a product.

Also Known As

  • China root
  • China tuckahoe
  • Fu ling
  • Hoelen
  • Matsuhodo

Health Benefits

Poria contains several substances thought to promote good health, including:

  • Polysaccharides, which are known to enhance immune function
  • Triterpenoids, a class of compounds with antioxidant effects

The mushrooms have several beneficial activities, including:

  • Antitumor
  • Anti-inflammation
  • Antioxidant
  • Anti-aging
  • Immunomodulatory

Early research suggests that poria may be useful in treating:

Several other uses have less evidence but show promise.

Alzheimer's Disease

Preliminary research suggests that poria mushrooms may help fight Alzheimer's disease.

A 2021 study on mice showed that poria helped the brain clear beta-amyloid (ßA) from the brain. ßA is what forms plaques that cause Alzheimer's symptoms.

It also improved gut health, which is important in Alzheimer's due to the brain-gut axis. The end result was that poria improved cognitive function.

This builds on earlier research that showed Poria extract reduced oxidative stress on biopsied brain cells obtained from rats.

At that time, researchers suggested P. cocos may help shield the brain from the toxic effects of ßA. The more recent study not only confirms this but suggests a mechanism.


Several studies suggest poria may have anti-tumor properties. It may help fight or prevent certain forms of cancer, including:

A 2018 study reported an extract of P. cocos showed cell-killing abilities in four human lung cancer cell lines.

A 2020 study found it improved the anti-tumor effect of drug treatment and also reversed drug resistance, which can be a problem in people with cancer.

Another 2020 study showed a compound from poria mushrooms (pachymic acid) killed breast cancer cells. Researchers noted that pachymic acid has the potential to be used as a low-side-effect treatment.

Other research has identified a polysaccharide (a type of sugar) in poria as a potential anti-tumor drug.

The mushroom also appears to make changes to the immune system that help defeat cancer.

These are all lab or animal studies. We'll need human trials to know for sure whether poria is a safe and effective cancer treatment.


Poria mushrooms may be effective against type-2 diabetes.

In a 2011 study, researchers found an extract of P. cocos significantly lowered blood sugar levels in mice. They credited triterpenes, which are believed to improve insulin sensitivity, for this effect.

A 2016 study showed an herbal blend including poria lessened insulin resistance in rats.

In theory, taking a poria supplement with meals may reduce blood sugar fluctuations in people with diabetes or insulin resistance. However, this has yet to be proven in research.


Poria is a mushroom long used in traditional Chinese medicine. It's being studied as a potential treatment for Alzheimer's disease, type-2 diabetes, and several types of cancer.

Other Benefits

Other potential benefits of poria are less well-researched and still in lab and animal testing. More research needs to be done, but research so far is promising for these uses.

  • Depression: Fights depression by increasing serotonin and dopamine, lowering inflammation in the frontal cortex
  • Digestive problems: Improves intestinal health, restores gut flora, protects against chemotherapy damage
  • Heart disease: Protects against atherosclerosis by reducing inflammation, cholesterol, triglycerides, and oxidative stress
  • Hemorrhagic fever: Increases immune response against the Marburg virus, which causes hemorrhagic fever; being considered as a vaccine
  • Hyperpigmentation: Used topically, lowers melanin activity to reduce freckles and skin-darkening conditions
  • Insomnia: Improves sleep through action on the calming neurotransmitter GABA
  • Kidney damage: Protects against damage due to infection or other causes
  • Liver toxicity: Protects against damage from acetaminophen and fatty liver disease
  • Osteoporosis: Reduces bone loss and bone marrow changes in postmenopausal osteoporosis
  • Skin aging: Reduces oxidative stress damage (aging) to skin, may be effective in skin-care products

Possible Side Effects

While poria has been used for centuries, that doesn't mean it's safe.

Not enough research has been done, especially in humans, to gauge poria's side effects. Little is known about safety, long-term risks, or possible drug interactions.

Supplements and herbal remedies are largely unregulated in the United States. They don't have to go through the testing pharmaceutical drugs do.

Imported natural remedies pose a risk of contamination. It's even possible that they don't contain the ingredients listed on the product label.

If you experience any side effects (like vomiting or diarrhea) after consuming poria, let your healthcare provider know.

Not much is known about the safety of poria mushrooms during pregnancy or breastfeeding. If you are pregnant or nursing, you may want to err on the side of caution and avoid poria mushrooms in any form.

Poria tablets

Verywell / Anastasia Tretiak

Dosage and Preparation

No guidelines are established for dosages of poria mushrooms. Studies show low toxicity levels, meaning it takes a large amount to cause an overdose.

But beyond that, poria's side effects profile is generally unknown.

When taken in tablet or capsule form, poria is typically dosed at anywhere from:

  • 500 milligrams (mg) once daily
  • 1,200 mg twice daily

Never exceed the manufacturer's dosing recommendations.

Pre-packaged granules usually come in sachets that you mix with boiling water. The flavor is described as sweet, but bland.

To prepare a tonic without the granules, you can steep mushrooms in boiling water.

Some people even make porridges, soups, and rice cakes from reconstituted or powdered mushrooms. transforming the medicinal remedy into a culinary treat.


Poria shows some promise as a treatment for many conditions, including depression, heart disease, liver and kidney damage, and osteoporosis. Little is known about side effects and drug interactions but studies show the toxicity level is low.

Standard dosages aren't established. Never take more than what the label says. Poria comes in capsules and granules to put in water. Some people cook it into food.

What to Look for

Products used in traditional Chinese medicine may pose safety concerns because they are so loosely regulated. In the past, products have been tainted with heavy metals, pesticides, and even drugs.

When buying poria supplements or powders, opt for well-known brands that have been voluntarily submitted for testing by an independent certifying body like:

  • U.S. Pharmacopeia (USP)
  • NSF International
  • ConsumerLab

Certification of herbal supplements is increasing and has been embraced by some larger manufacturers.

Certification guarantees a product contains what its label says it does and is free from contaminants. It does not guarantee safety or effectiveness.

The U.S. Food and Drug Administration (FDA) bars manufacturers of dietary supplements from making any unproven or misleading claims about cures or other health benefits. Those kinds of statements could be a red flag that a company isn't reputable.

If buying imported whole dried poria mushrooms, do not assume they are safe because they come in a sealed container. If there are any signs of mold or moisture, discard them immediately.


Poria cocos has been used in TCM for 2,000 years. It's showing promise as a treatment for numerous health conditions, especially Alzheimer's, cancer, and diabetes. It may also have benefits for digestion, insomnia, depression, osteoporosis, and skin aging.

The safety profile of poria isn't yet established. Toxicity appears to be low. Report any negative side effects to your healthcare provider.

You can take poria as a capsule or tonic, or put it in food. Look for products tested by independent labs.

A Word From Verywell

It's easy to think of natural products as "safe." However, they can cause side effects and drug interactions just like pharmaceutical products.

Don't delay conventional treatment in favor of poria or other alternative treatments. That can have dire effects on your outcome, especially when it comes to cancer.

To protect your health, involve your healthcare provider in all your treatment decisions, including poria and other natural products. They may be able to spot potential problems based on your overall health and what medications you're taking.

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  1. Li X, He Y, Zeng P, et al. Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in ChinaJ Cell Mol Med. 2019;23(1):4-20. doi:10.1111/jcmm.13564

  2. Sun Y, Liu Z, Pi Z, Song F, Wu J, Liu S. Poria cocos could ameliorate cognitive dysfunction in APP/PS1 mice by restoring imbalance of Aβ production and clearance and gut microbiota dysbiosis [published online ahead of print, 2021 Jan 11]. Phytother Res. 2021;10.1002/ptr.7014. doi:10.1002/ptr.7014

  3. Park YH, Son IH, Kim B, Lyu YS, Moon HI, Kang HW. Poria cocos water extract (PCW) protects PC12 neuronal cells from beta-amyloid-induced cell death through antioxidant and antiapoptotic functions. Pharmazie. 2009 Nov;64(11):760-4.

  4. Cheng S, Castillo V, Sliva D. CDC20 associated with cancer metastasis and novel mushroom‑derived CDC20 inhibitors with antimetastatic activityInt J Oncol. 2019;54(6):2250-2256. doi:10.3892/ijo.2019.4791

  5. Lin TY, Lu MK, Chang CC. Structural identification of a fucose-containing 1,3-β-mannoglucan from Poria cocos and its anti-lung cancer CL1-5 cells migration via inhibition of TGFβR-mediated signalingInt J Biol Macromol. 2020;157:311-318. doi:10.1016/j.ijbiomac.2020.04.014

  6. Jiang Y, Fan L. The effect of Poria cocos ethanol extract on the intestinal barrier function and intestinal microbiota in mice with breast cancerJ Ethnopharmacol. 2021;266:113456. doi:10.1016/j.jep.2020.113456

  7. Wang N, Liu D, Guo J, Sun Y, Guo T, Zhu X. Molecular mechanism of Poria cocos combined with oxaliplatin on the inhibition of epithelial-mesenchymal transition in gastric cancer cellsBiomed Pharmacother. 2018;102:865-873. doi:10.1016/j.biopha.2018.03.134

  8. Xu H, Wang Y, Zhao J, et al. Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidenceChem Biol Drug Des. 2020;95(5):493-502. doi:10.1111/cbdd.13610

  9. Lee S, Lee S, Roh HS, et al. Cytotoxic constituents from the sclerotia of Poria cocos against human lung adenocarcinoma cells by inducing mitochondrial apoptosis. Cells. 2018;7(9):116. doi:10.3390/cells7090116

  10. Li Y, Li X, Lu Y, et al. Co-delivery of Poria cocos extract and doxorubicin as an 'all-in-one' nanocarrier to combat breast cancer multidrug resistance during chemotherapy [published correction appears in Nanomedicine. 2021 Jul;35:102336]. Nanomedicine. 2020;23:102095. doi:10.1016/j.nano.2019.102095

  11. Jiang Y, Fan L. Evaluation of anticancer activities of Poria cocos ethanol extract in breast cancer: In vivo and in vitro, identification and mechanismJ Ethnopharmacol. 2020;257:112851. doi:10.1016/j.jep.2020.112851

  12. Li X, Ma L, Zhang L. Molecular basis for Poria cocos mushroom polysaccharide used as an antitumor drug in ChinaProg Mol Biol Transl Sci. 2019;163:263-296. doi:10.1016/bs.pmbts.2019.02.011

  13. Tian H, Liu Z, Pu Y, Bao Y. Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-κB signaling in vitro and in vivoBiomed Pharmacother. 2019;112:108709. doi:10.1016/j.biopha.2019.108709

  14. Li TH, Hou CC, Chang CL, Yang WC. Anti-hyperglycemic properties of crude extract and triterpenes from Poria cocos. Evid Based Complement Alternat Med. 2011;2011:128402. doi:10.1155/2011/128402

  15. Dai B, Wu Q, Zeng C, et al. The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistanceJ Ethnopharmacol. 2016;192:382-389. doi:10.1016/j.jep.2016.07.024

  16. Huang YJ, Hsu NY, Lu KH, et al. Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammationJ Ethnopharmacol. 2020;258:112566. doi:10.1016/j.jep.2020.112566

  17. Xu H, Wang Y, Jurutka PW, et al. 16α-hydroxytrametenolic acid from Poria cocos improves intestinal barrier function through the glucocorticoid receptor-mediated PI3K/Akt/NF-κB pathwayJ Agric Food Chem. 2019;67(39):10871-10879. doi:10.1021/acs.jafc.9b04613

  18. Liu J, Yu J, Peng X. Poria cocos Polysaccharides alleviates chronic nonbacterial prostatitis by preventing oxidative stress, regulating hormone production, modifying gut microbiota, and remodeling the DNA methylomeJ Agric Food Chem. 2020;68(45):12661-12670. doi:10.1021/acs.jafc.0c05943

  19. Zou YT, Zhou J, Wu CY, et al. Protective effects of Poria cocos and its components against cisplatin-induced intestinal injuryJ Ethnopharmacol. 2021;269:113722. doi:10.1016/j.jep.2020.113722

  20. Li W, Yu J, Zhao J, et al. Poria cocos polysaccharides reduces high-fat diet-induced arteriosclerosis in ApoE-/- mice by inhibiting inflammationPhytother Res. 2021;35(4):2220-2229. doi:10.1002/ptr.6980

  21. Zhao J, Niu X, Yu J, et al. Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCsInt Immunopharmacol. 2020;80:106173. doi:10.1016/j.intimp.2019.106173

  22. Gai W, Zheng X, Wang C, et al. Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in miceVirol J. 2017;14(1):204. Published 2017 Oct 25. doi:10.1186/s12985-017-0869-3

  23. Lee H, Cha HJ. Poria cocos Wolf extracts represses pigmentation in vitro and in vivoCell Mol Biol (Noisy-le-grand). 2018;64(5):80-84. Published 2018 Apr 30.

  24. Shah VK, Choi JJ, Han JY, Lee MK, Hong JT, Oh KW. Pachymic acid enhances pentobarbital-induced sleeping behaviors via GABAA-ergic systems in miceBiomol Ther (Seoul). 2014;22(4):314-320. doi:10.4062/biomolther.2014.045

  25. Jiang GP, Liao YJ, Huang LL, Zeng XJ, Liao XH. Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injuryMol Med Rep. 2021;23(1):63. doi:10.3892/mmr.2020.11704

  26. Wu K, Guo C, Yang B, Wu X, Wang W. Antihepatotoxic benefits of Poria cocos polysaccharides on acetaminophen-lesioned livers in vivo and in vitroJ Cell Biochem. 2019;120(5):7482-7488. doi:10.1002/jcb.28022

  27. Kim JH, Sim HA, Jung DY, et al. Poria cocus Wolf extract ameliorates hepatic steatosis through regulation of lipid metabolism, inhibition of ER stress, and activation of autophagy via AMPK activationInt J Mol Sci. 2019;20(19):4801. Published 2019 Sep 27. doi:10.3390/ijms20194801

  28. Hwang YH, Jang SA, Lee A, Kim T, Ha H. Poria cocos ameliorates bone loss in ovariectomized mice and inhibits osteoclastogenesis in vitroNutrients. 2020;12(5):1383. Published 2020 May 12. doi:10.3390/nu12051383

  29. Fang CL, Paul CR, Day CH, et al. Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2-antioxidant mechanism to exert anti-skin aging effects in human dermal fibroblastsEnviron Toxicol. 2021;36(5):729-736. doi:10.1002/tox.23075

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