What Is Rutin?

Rutin capsules, tablets, powder, asparagus, apple, and buckwheat

Verywell / Anastasia Tretiak

Rutin is a plant pigment, or bioflavonoid, found naturally in common foods like apple peels, black tea, asparagus, buckwheat, onions, green tea, figs, and most citrus fruit. Besides getting it from food, you can also find rutin in supplement form, such as tablets or capsules. Rutin contains quercetin, an antioxidant shown to reduce inflammation.

This article discusses rutin, sources of rutin, and potential side effects associated with its use.

Dietary supplements are not regulated in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. When possible, choose a supplement that has been tested by a trusted third party, such as USP, ConsumerLabs, or NSF. However, even if supplements are third-party tested, that doesn't mean they are necessarily safe for all or effective in general. It is important to talk to your healthcare provider about any supplements you plan to take and check in about any potential interactions with other supplements or medications.

Supplement Facts


  • Active ingredient(s): Rutin
  • Alternate Name(s): Rutoside, quercetin-3-rutinoside, sophorin
  • Suggested Dose: Not enough data
  • Safety Considerations: Avoid use in pregnant and lactating people and children. Discuss with a healthcare provider regarding supplement use with chronic conditions and/or prescribed medications to avoid interactions.

Uses of Rutin

Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietician, pharmacist, or healthcare provider. No supplement is intended to treat, cure, or prevent a disease.

To date, very few clinical trials have tested the potential health benefits of rutin. The little research that has been done often uses a supplement formulation with multiple ingredients, making it difficult to determine which component had any effect.

Blood Vessel Health

Different studies have assessed rutin's role in conditions affecting the blood vessels, including chronic venous insufficiency and varicose veins.

Chronic Venous Insufficiency

Chronic venous insufficiency (CVI) is a condition that affects the venous systems in the lower limbs. In CVI, the venous valves in the legs are not working correctly, causing blood to flow back downward and pool in the veins. This can cause leg discomfort, heaviness, cramps, and pain.

A systematic review published in the Journal of Clinical Pharmacy and Therapeutics in 2015 concluded that a partially synthetic derivative of rutin called hydroxyethylrutosides moderately improved symptoms of CVI. However, better quality studies are needed.

Varicose Veins

Pregnancy can increase the risk of developing varicose veins, which occurs when the valves inside the veins weaken. As a result, the veins become enlarged and dark in appearance.

A report in the Cochrane Database of Systematic Reviews indicated that rutoside (a compound found in rutin) might help relieve the symptoms of varicose veins in late pregnancy. However, the study only included 69 women; therefore, there was not enough data to assess the safety of rutoside use during pregnancy or its effectiveness.

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Things You Might Not Know About Varicose Veins

What Are the Side Effects of Rutin?

Rutin is generally considered safe when consumed in the amounts found in foods like citrus, onions, and apples. However, rutin supplements may cause specific side effects, including:

  • Headache
  • Rashes
  • Muscle tension
  • Changes in heartbeat
  • A high white blood cell count (leukocytosis)
  • Blurred vision
  • Fluid accumulation in your knees
  • Upset stomach
Asparagus, apple, and buckwheat

Verywell / Anastasia Tretiak

Precautions

There is not enough data on the safety of rutin in pregnant or lactating people. Therefore, pregnant and nursing individuals should not take rutin. Also, do not give children rutin supplements without discussing their use with a healthcare provider.

Before taking rutin supplements, talk to your healthcare provider if you:

  • Have a history of heart disease or blood clots
  • Are taking blood thinning medications (e.g., warfarin)
  • Have diabetes and are taking blood sugar lowering medications: Rutin may lower blood sugar levels. Therefore, people with diabetes should monitor blood sugar levels closely, especially if adding rutin to a regimen that already includes blood sugar lowering medications.
  • Have any chronic conditions or require medications

Dosage: How Much Rutin Should I Take?

Rutin is not an essential nutrient and there is no recommended dietary allowance (RDA) for rutin.

There is not enough scientific data to provide a recommended dose of rutin. Different doses have been used in research studies, but rutin is often combined with other herbal ingredients. The appropriate dose for you may depend on factors including your age, sex, and medical history. Speak to your healthcare provider to get personalized advice.

What Happens If I Take Too Much Rutin?

Side effects are more likely to occur with high doses of rutin. If you decide to supplement with rutin be sure to follow the directions on the label and discuss it with your healthcare provider first.

Interactions

Rutin should be avoided if you have been prescribed warfarin, a blood thinner, as it may reduce the medication's anticoagulant (blood thinning) effect.

Because rutin can also lower blood sugar, it should be used carefully in people with diabetes who take blood sugar lowering medications. Taking rutin supplements with these medications may cause blood sugar to drop too low, contributing to hypoglycemia (low blood sugar).

Frequently Asked Questions

  • How much rutin should I take?

    There isn't enough evidence to recommend supplementing with rutin. There also isn't enough research to recommend a specific dose. If you decide to supplement with rutin, be sure to follow the directions on the supplement label. You should always discuss your supplement regimen with a healthcare provider to avoid any potential interactions with other medications.

  • Should I take rutin to prevent varicose veins during pregnancy?

    There is very little research suggesting that rutin may help prevent or treat varicose veins. Additionally, there is not enough data to determine if rutin supplementation is safe to take during pregnancy. Therefore, it is best to avoid rutin supplements while pregnant. Instead, consult with your healthcare provider if you have concerns about varicose veins.

  • What are good sources of rutin?

    Apples (including the skin) and buckwheat are great sources of rutin. Rutin is a plant pigment found in fruits and vegetables. Other good sources include raspberries, asparagus, figs, olives, and capers.

Sources of Rutin & What to Look For

Rutin is a plant pigment found in several fruits and vegetables. It is also added to supplements, often as one ingredient combined with several others.

Food Sources of Rutin

Buckwheat is an excellent source of rutin. Other food sources include:

  • Apples (unpeeled)
  • Some black and green teas
  • Roobios tea (a red herbal tea)
  • Asparagus
  • Raspberries
  • Figs
  • Olives
  • Capers

Rutin Supplements


Rutin supplement forms, such as tablets or capsules, are sold online and in natural food stores or stores specializing in dietary supplements.

If you choose to buy the supplement, the National Institutes of Health (NIH) recommends looking for a Supplement Facts label on all products. This label will contain vital information such as the amount of active ingredients per serving and other added ingredients (like fillers, binders, and flavorings).

Lastly, the organization suggests you look for a product with a seal of approval from a third-party organization that provides quality testing. These organizations include U.S. Pharmacopeia, ConsumerLab.com, and NSF International. A seal of approval from one of these organizations does not guarantee the product's safety or effectiveness. Still, it does assure that the product was properly manufactured, contains the ingredients listed on the label, and does not contain harmful levels of contaminants.

Summary

Rutin is a plant pigment found naturally in foods. It is also available in supplement form and is often added to preparations that include multiple ingredients. However, there is not enough data to recommend its use for any health conditions or to provide a recommended dose. In general, it's best to consult a healthcare provider before adding rutin supplements to your regimen, especially if you take other medications or supplements.

For now, your best bet to get rutin is to include foods such as apples, buckwheat, figs, and raspberries in your diet.

7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Ganeshpurkar A, Saluja AK. The pharmacological potential of rutin. Saudi Pharm J. 2017;25(2):149-164. doi: 10.1016/j.jsps.2016.04.025

  2. Aziz Z, Tang WL, Chong NJ, Tho LY. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. J Clin Pharm Ther. 2015;40(2):177-185. doi:10.1111/jcpt.12247

  3. Smyth RM, Aflaifel N, Bamigboye AA. Interventions for varicose veins and leg oedema in pregnancy. Cochrane Database Syst Rev. 2015;(10):CD001066. doi:10.1002/14651858.CD001066.pub3

  4. Al-Dhabi NA, Arasu MV, Park CH, Park SU. An up-to-date review of rutin and its biological and pharmacological activities. EXCLI J. 2015;14:59-63. doi:10.17179/excli2014-663

  5. Chan E, Hegde A, Chen X. Effect of rutin on warfarin anticoagulation and pharmacokinetics of warfarin enantiomers in rats. J Pharm Pharmacol. 2009;61(4):451-458. doi:10.1211/jpp/61.04.0006

  6. Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: A bioactive flavonoidPharmacogn Rev. 2016;10(20):84-89. doi:10.4103/0973-7847

  7. National Institute of Health. Dietary supplements: what you need to know.

Additional Reading
  • Rutin. Natural Medicines Database. Professional Monograph.

  • Kauss T, Moynet D, Rambert J, et al. Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis. Arthritis Res Ther.

By Jennifer Lefton, MS, RD/N, CNSC, FAND
Jennifer Lefton, MS, RD/N-AP, CNSC, FAND is a Registered Dietitian/Nutritionist and writer with over 20 years of experience in clinical nutrition. Her experience ranges from counseling cardiac rehabilitation clients to managing the nutrition needs of complex surgical patients.

Originally written by
Cathy Wong
Cathy Wong

Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health.

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