Vitiligo and Psoriasis: Is There a Connection?

Vitiligo and psoriasis are skin diseases that can occur separately or simultaneously. The reasons for that aren’t fully understood, but researchers suspect genetic differences point to a common underlying problem with the immune system.

This article explores connections between vitiligo and psoriasis, what research has uncovered, plus prevention and treatment for both conditions.

A woman with vitiligo stands with her arms crossed. White patches can be seen on her forearms.

Vesnaandjic / Getty Images

Vitiligo vs. Psoriasis

About 1% of the population has vitiligo, which causes skin patches to lose all of their melanin (pigment). That leaves white blotches, especially on the following parts of the body:

  • Face, especially around the mouth and eyes
  • Inside the mouth
  • Neck
  • Armpits
  • Hands and wrists
  • Groin and genitals

It can also affect the hair. Vitiligo is especially noticeable in people with darker skin.

A man has large patches of psoriasis on his arm and belly.

Irina Gulyayeva / Getty Images

Psoriasis is more common, affecting about 3% of the population. Psoriasis involves skin cells that multiply too fast, causing them to build up. That leads to thick, discolored skin with silver scales.

Patches can be anywhere, but are most common on the:

  • Face
  • Back
  • Elbows
  • Palms
  • Knees
  • Feet

Both vitiligo and psoriasis are autoimmune skin diseases. That means the immune system mistakenly attacks cells in a part of your body as if they were a threat like a bacteria or virus.

The exact triggers of these disorders (and autoimmune diseases in general) aren’t yet understood. Researchers believe they involve a genetic predisposition that makes you vulnerable. Then, if you encounter the right set of environmental triggers, the disease develops.

It’s common to have more than one autoimmune disease. Vitiligo and psoriasis sometimes occur together.


Vitiligo and psoriasis are both autoimmune diseases. Vitiligo causes the destruction of pigment and creates white patches of skin. Psoriasis causes the buildup of dead cells and leads to discolored patches with silvery scales. Due to common genetics and immune dysfunction, some people have both conditions.

What Research Says

Little is known about the relationship between vitiligo and psoriasis. However, research is ongoing.

A small 2021 study looked at a group of 436 vitiligo patients and found that 74 of them (about one-fifth of the participants) had a history of psoriasis either currently or in the past. More than 50% of the people with both conditions were diagnosed with psoriasis first.

In 12 people, psoriasis patches occurred in the same places as the vitiligo white spots. This has been seen in other studies, as well.

The risk appears to go both ways: People with psoriasis have an increased risk of developing vitiligo, and people with vitiligo have an increased risk of developing psoriasis.

The connection appears to be in the immune system. Both conditions involve an autoimmune response to melanocytes (pigment cells) or proteins derived from melanocytes.

Vitiligo and psoriasis are associated with other autoimmune and skin diseases, as well.


Vitiligo and psoriasis both increase your risk of developing the other skin condition. Psoriasis plaques are sometimes confined to the white vitiligo patches. Experts believe this is due to similarities in the immune system, especially in regard to actions taken against melanocytes (pigment cells).


So far, experts know of no way to prevent either vitiligo or psoriasis. They also can’t be cured.

Lifestyle factors that may help with prevention include:

  • Eating a healthy diet with lots of leafy greens and antioxidants
  • Learning to manage stress
  • Preventing skin damage from the sun, insect bites, scratches, tattoos, etc.
  • Avoiding infections

Psoriasis White Patches

Sometimes, psoriasis lesions can cause depigmentation of the skin. That leaves white patches behind when the lesion heals. It can be hard to tell vitiligo from psoriasis white patches.


Treatment may slow or stop the progression of these diseases, as well as ease symptoms. Fortunately for those who have both, some treatments are the same or similar.


Treatments for vitiligo focus on repigmenting the skin. They include:

  • Topical medication: Strong corticosteroids and Janus kinase (JAK) inhibitors such as Opzelura (ruxolitinib)
  • Light treatment: Lasers, light boxes, or UVA light combined with the drug psoralen 
  • Surgery: Skin grafting of pigmented skin into depigmented areas
  • Supplements: Ginkgo biloba has some clinical evidence; others haven’t been studied

Nutritional deficiencies may play a role in vitiligo. These include:

Ask your healthcare provider if you should make any dietary changes. They may want to test your blood for deficiencies.

Some healthcare providers prescribe supplements to stabilize the immune system, such as:

During treatment or if treatment isn’t effective, many people try to conceal the blotches. Options include:

  • Camouflage: It’s common to cover white patches with makeup or self-tanner.
  • Depigmentation: In rare cases, a skin cream is used to remove all remaining melanin from the skin, leaving all of the skin white. This takes between one and four years to accomplish.


Psoriasis treatments include:

  • Topical medication: Steroid creams, medicated lotions and shampoos
  • Light treatment: Lasers, light boxes, or UVA light combined with the drug psoralen 
  • Medications: Retinoids, and in severe cases, methotrexate or cyclosporine

JAK Inhibitors

A newer class of drugs called JAK inhibitors has shown promise in studies as a treatment for vitiligo and psoriasis. It’s being researched in both oral and topical forms. Opzelura (ruxolitinib) cream is the first FDA-approved topical treatment for nonsegmental vitiligo in patients 12 years of age and older. JAK inhibitors reverse overactivity in the immune system.


Vitiligo and psoriasis are autoimmune diseases with related genetic predispositions. Vitiligo destroys pigment and creates white patches of skin. Psoriasis causes discolored patches with silvery scales. Some people have both of them, and sometimes, psoriasis only appears in vitiligo patches.

Having one of these disorders increases your risk of the other. Both involve immune reactions to melanocytes.

Treatments for these conditions have some overlap, such as corticosteroid creams and light therapy. Other vitiligo treatments include supplements or surgery to place pigmented skin in white patches. Other psoriasis treatments include medications such as anthralin or methotrexate.

A Word From Verywell

Having one skin condition is hard enough on your self-esteem. Having two is especially difficult.

Rest assured, effective treatments are available for vitiligo and psoriasis. Some of them will even help both conditions.

Talk to your healthcare provider about your options and start working toward better skin.

Frequently Asked Questions

  • How do you pronounce vitiligo?

    Vitiligo is pronounced vih-tuh-LYE-go.

  • Is vitiligo an autoimmune disease?

    Yes, it is an autoimmune disease. The immune system misidentifies melanin (pigment) cells called melanocytes as a danger. It then sets out to destroy them. That’s what causes the white patches, also called depigmentation.

19 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Canu D, Shourick J, Andreu N, et al. Demographic and clinical characteristics of patients with both psoriasis and vitiligo in a cohort of vitiligo patients: a cross-sectional study. J Eur Acad Dermatol Venereol. 2021;35(10):e676-e679. doi:10.1111/jdv.17383

  2. Baldini E, Odorisio T, Sorrenti S, et al. Vitiligo and autoimmune thyroid disorders. Front Endocrinol (Lausanne). 2017;8:290. doi:10.3389/fendo.2017.00290

  3. National Health Services. Overview: vitiligo.

  4. National Psoriasis Foundation. Psoriasis statistics.

  5. MedlinePlus. Psoriasis.

  6. Inserro A. Exploring the common characteristics in psoriasis and vitiligo. American Journal of Managed Care.

  7. Sharquie KE, Salman HA, Yaseen AK. Psoriasis and vitiligo are close relatives. Clin Cosmet Investig Dermatol. 2017;10:341-345. doi:10.2147/CCID.S142819

  8. Yen H, Chi CC. Association between psoriasis and vitiligo: a systematic review and meta-analysis. Am J Clin Dermatol. 2019;20(1):31-40. doi:10.1007/s40257-018-0394-1

  9. Furue K, Ito T, Tsuji G, Kadono T, Nakahara T, Furue M. Autoimmunity and autoimmune co-morbidities in psoriasis. Immunology. 2018;154(1):21-27. doi:10.1111/imm.12891

  10. Dahir AM, Thomsen SF. Comorbidities in vitiligo: comprehensive review. Int J Dermatol. 2018;57(10):1157-1164. doi:10.1111/ijd.14055

  11. Stanford Health Care. Psoriasis: prevention.

  12. Vitiligo Society. Living with vitiligo.

  13. American Academy of Dermatology Association. Are triggers causing your psoriasis flare-ups?

  14. American Academy of Dermatology Association. Vitiligo: tips for managing.

  15. National Psoriasis Foundation. Causes and triggers.

  16. American Academy of Dermatology Association. Vitiligo: diagnosis and treatment.

  17. Vitiligo Support International. Vitamins and supplements.

  18. Food And Drug Administration. Opzelura label.

  19. Ciechanowicz P, Rakowska A, Sikora M, Rudnicka L. JAK-inhibitors in dermatology: current evidence and future applications. J Dermatolog Treat. 2019;30(7):648-658. doi:10.1080/09546634.2018.1546043

By Adrienne Dellwo
Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic.