COPD Chronic Bronchitis Differences Between Chronic Bronchitis and Emphysema These two subtypes of COPD usually coexist By Deborah Leader, RN Deborah Leader, RN Deborah Leader RN, PHN, is a registered nurse and medical writer who focuses on COPD. Learn about our editorial process Updated on May 12, 2020 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Sanja Jelic, MD Medically reviewed by Sanja Jelic, MD Sanja Jelic, MD is board-certified in pulmonary disease, sleep medicine, critical care medicine, and internal medicine. She is an assistant professor and attending physician at Columbia University College of Physicians and Surgeons in New York, NY. Learn about our Medical Expert Board Print Table of Contents View All Table of Contents Symptoms Causes Diagnosis Treatment Many people who have been diagnosed with chronic obstructive pulmonary disease (COPD) wonder what the difference is between the two main subtypes of the disease, chronic bronchitis and emphysema. Chronic bronchitis affects the airways, while emphysema affects the air sacs. And while that sounds distinct enough, both can cause difficulty breathing, and the two conditions usually coexist. Daniel Allan / Getty Images Learning more about their distinctive symptoms and underlying causes can help you better understand how chronic bronchitis and emphysema differ. Symptoms As both conditions affect the lungs, both chronic bronchitis and emphysema are marked by similar symptoms of shortness of breath and wheezing, but there are some differences, particularly in the late stages of the diseases. Symptoms of Chronic Bronchitis Coughing up clear or white mucus Shortness of breath Chest discomfort or tightness Wheezing Fatigue Symptoms of Emphysema Persistent cough Long-term mucus production Shortness of breath An ongoing feeling that you're not getting enough air Wheezing Fatigue Symptoms Specific to Chronic Bronchitis Chronic bronchitis causes inflammation in the bronchioles of the lungs. The bronchioles connect the trachea, or windpipe, to the lungs and are used to carry air in and out of the lungs. This irritation causes an increased amount of heavy mucus in the lungs that, over time, interferes with breathing. The body responds to this mucus by producing a cough in an attempt to clear the airways. Because the mucus (also referred to as phlegm or sputum) is so abundant and thick, it's often difficult for a person with chronic bronchitis to expel it. This is why they may experience a cough every day for an extended period of time. This differentiates the condition from acute bronchitis. Additionally, large amounts of thick mucus make the lungs a perfect habitat for bacteria to thrive. For this reason, bacterial lung infections among people who have chronic bronchitis are common and frequent. In the later stages of chronic bronchitis, the skin, nails, and lips may develop a bluish tinge. This is caused by the lack of oxygen in the bloodstream, a condition known as cyanosis. Decreased oxygen can also lead to swelling in the legs and ankle (peripheral edema). Symptoms Specific to Emphysema Emphysema refers to the damage and destruction done to the walls of the alveoli, the tiny air spaces in the lungs where oxygen and carbon dioxide are exchanged during the breathing process. The alveoli provide oxygen to the bloodstream so when they are destroyed, it is difficult for the person with emphysema to breathe. Emphysema also causes the lungs to gradually lose their elasticity. The lack of oxygen combined with the build-up of carbon dioxide can cause irreparable damage. Causes Both chronic bronchitis and emphysema are primarily caused by cigarette smoking. Chronic bronchitis may also be caused by secondhand smoke and air pollution, which irritates the airways and leads to increased inflammation. According to the Centers for Disease Control and Prevention (CDC), the number of adults living with chronic bronchitis continues to grow in the U.S. with numbers now exceeding 15 million. The risk of emphysema is associated with the duration of smoking and the number of cigarettes smoked each day. Non-smokers can also develop emphysema if regularly exposed to secondhand smoke. Statistics from the CDC show that 3.8 million Americans have been diagnosed with emphysema. The Health Risks of Secondhand Smoke Diagnosis One main difference between chronic bronchitis and emphysema is that chronic bronchitis has a specific diagnosis—someone who has a chronic cough with mucus production every day for at least three months, for two years in a row. On the other hand, emphysema is a pathological term that refers to the actual damage to the alveoli. Regardless, the diagnosis of either chronic bronchitis or emphysema requires a thorough medical history, physical examination, and a simple breath test called spirometry, which measures how well your lungs are functioning. Spirometry can be performed in your healthcare provider's office and is noninvasive; it only requires you to breathe into a mouthpiece. Bronchitis Doctor Discussion Guide Get our printable guide for your next doctor's appointment to help you ask the right questions. Download PDF Email the Guide Send to yourself or a loved one. Sign Up This Doctor Discussion Guide has been sent to {{form.email}}. There was an error. Please try again. Treatment While there is no cure yet for emphysema or chronic bronchitis, there are scientifically proven treatment options that can help slow the progression of the disease and the reduction of symptoms. Treatment may involve oral drugs, inhaled medications, and surgery. Lifestyle changes are also central to treatment. Chief among these is the cessation of smoking, either by going cold turkey or using smoking aids. Without the complete termination of cigarettes, there is little way to either slow the disease or reduce the severity of illness. By kicking the habit, exercising regularly, losing weight, and using the appropriate medications, you can significantly reduce COPD symptoms and increase both your lifespan and quality of life. A Word From Verywell Even though both types of COPD are usually progressive, meaning they often get worse over time, the good news is that there are therapies like inhalers, oxygen, and pulmonary rehabilitation that can improve your quality of life. In addition, you can also be proactive in your care by not smoking and ensuring you are up to date on your flu and pneumonia vaccines. Talk to your healthcare provider about finding a care plan that works for you. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 7 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Kaminsky DA. "All that wheezes is not asthma" (or COPD)!. Chest. 2015;147(2):284-286. doi:10.1378/chest.14-1813 Cleveland Clinic. Bronchitis. Widysanto A, Mathew G. Chronic bronchitis. In: StatPearls. LaLicata K. Know the warning signs of COPD. In: Contemporary Clinic. Pahal P, Avula A, Sharma S. Emphysema. In: StatPearls. Centers for Disease Control and Prevention. Basics about COPD. Centers for Disease Control and Prevention. Chronic Obstructive Pulmonary Disease. Additional Reading Han MK, Dransfield MT, Martinez FJ. Chronic Obstructive Pulmonary Disease: Definition, Clinical Manifestations, Diagnosis, and Staging. In: UpToDate, Stoller JK (ed), UpToDate, Waltham, MA.