Cancer Prostate Cancer The Prostate Cancer-Breast Cancer Link By Matthew Schmitz, MD linkedin Matthew Schmitz, MD, is a professional radiologist who has worked extensively with prostate cancer patients and their families. Learn about our editorial process Matthew Schmitz, MD Medically reviewed by Medically reviewed by Doru Paul, MD on November 18, 2019 Doru Paul, MD, is triple board-certified in medical oncology, hematology, and internal medicine. He is an associate professor of clinical medicine at Weill Cornell Medical College and attending physician in the Department of Hematology Oncology at the New York Presbyterian Weill Cornell Medical Center. Learn about our Medical Review Board Doru Paul, MD Updated on January 24, 2020 Print Research has shown that there may be a link between prostate cancer and breast cancer. A family history of breast cancer is associated with an increased risk of prostate cancer. Certain genetic mutations that increase the risk of breast cancer may result in an increased risk of prostate cancer in men. And there are also similar biological processes that can contribute to the development of both of these types of cancers. However, breast cancer and prostate cancer are among the most common types of cancers, and they are not always associated with a family history or with recognized genetic mutations. Furthermore, there are treatments for these types of cancer, and they are more effective when they are initiated at an early stage. So it is important that you have your recommended health screenings even if you don't have any known risk factors. Breast Cancer and Prostate Cancer Men who have a personal history of breast cancer or a family history of breast cancer may be at a higher risk of getting prostate cancer. While the exact reasons for this link are not completely clear, both types of cancer are associated with inflammation and with similar processes of carcinogenesis (cancer cell development). BRCA Genes Mutations in two genes known as BRCA1 and BRCA2 are linked with a higher risk of breast cancer in women and men, and with a higher risk of ovarian cancer in women. These gene mutations are often inherited and run in families, but they can also develop de novo (without an inherited pattern). Men who have these genetic mutations are at an increased risk of prostate cancer, and possibly also testicular cancer, and pancreatic cancer. Mutations of both genes have been shown to be associated with a higher risk of developing prostate cancer, and evidence suggests that mutations in BRCA2 are more strongly correlated with prostate cancer risk. Prostate Cancer Testing While it has been shown that men with certain BRCA1 and BRCA2 mutations do have a higher risk of developing prostate cancer, having these mutations does not mean that a man will definitely develop prostate cancer. Additionally, most men who develop prostate cancer do not have BRCA mutations. Because there is not a strong correlation between BRCA mutations and the development of prostate cancer, there is some debate about whether genetic testing for BRCA mutations in men is useful. For men who have a strong family history of prostate cancer or breast cancer, genetic testing may provide some information about whether they share the same high-risk genetic mutations as family members who have developed either of these types of cancer. More frequent screening for prostate cancer could then be obtained if the mutation is found. For most men, however, genetic testing to search for the BRCA mutations is not likely to be of much use. If the mutation was found, it may lead a man to undergo earlier or more frequent testing, but the absence of the mutation should not convince a man that he is no longer at risk of prostate cancer (even early-onset prostate cancer). Was this page helpful? Thanks for your feedback! Limiting processed foods and red meats can help ward off cancer risk. These recipes focus on antioxidant-rich foods to better protect you and your loved ones. Sign up and get your guide! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Pilarski R. The role of testing in hereditary pancreatic and prostate cancer families. Am Soc Clin Oncol Educ Book. 2019;39:79-86. doi:10.1200/EDBK_238977 NIH National Cancer Institute. Common cancer types. Updated February 21, 2019. Barber L, Gerke T, Markt SC, et al. Family history of breast or prostate cancer and prostate cancer risk. Clin Cancer Res. 2018;24(23):5910-5917. doi:10.1158/1078-0432.CCR-18-0370 Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-associated hereditary breast and ovarian cancer. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews. Updated December 15, 2016. Friedenson B. BRCA1 and BRCA2 pathways and the risk of cancers other than breast or ovarian. MedGenMed. 2005;7(2):60. Oliva L, Lozano R, Llácer C, et al. Risk prediction tools available for germline BRCA1/2 mutations underperform in prostate cancer patients. Eur Urol Oncol. 2019;S2588-9311(19)30100-2. doi:10.1016/j.euo.2019.06.019