Thyroid Disease Related Conditions An Overview of Endocrine Issues and Autoimmune Diseases By Mary Shomon facebook twitter linkedin Mary Shomon is a writer and hormonal health and thyroid advocate. She is the author of "The Thyroid Diet Revolution." Learn about our editorial process Mary Shomon Medically reviewed by Medically reviewed by Lindsey Waldman, MD, RD on November 08, 2019 linkedin Lindsey Waldman, MD, RD, is a board-certified pediatrician and pediatric endocrinologist. Learn about our Medical Review Board Lindsey Waldman, MD, RD Updated on February 10, 2020 Print Table of Contents View All Table of Contents Endocrine Disorders Causes of Endocrine Disorders How Are Endocrine Disorders Diagnosed? What Is Autoimmune Disease? Causes of Autoimmune Diseases What Are the Symptoms of Autoimmune Disease? How Is Autoimmune Disease Diagnosed and Treated? Endocrine disorders are diseases and conditions that affect your endocrine system. The endocrine system includes your glands, which secrete hormones that have effects on other organs in the body. andresr / Getty Images Endocrine Disorders Your key endocrine glands include: Thyroid gland Pituitary gland Pineal gland Pancreas Ovaries Testes Parathyroid Hypothalamus Adrenals Some of the most common endocrine disorders include a number of thyroid-related conditions, including: Hypothyroidism Hyperthyroidism Hashimoto's Thyroiditis Graves' disease Thyroid cancer Goiter Thyroiditis Thyroid nodules Some other common endocrine disorders include: Adrenal disorders Diabetes Osteoporosis Pituitary disorders Polycystic ovary syndrome Causes of Endocrine Disorders Endocrine disorders have a number of causes, including: Some sort of dysfunction in the gland itself, which can be due to genetics, injury, or infection Benign or cancerous tumors or growths on the gland Autoimmune disease, where antibodies attack the gland A problem with the communications between endocrine glands, or a failure of one gland to stimulate another as needed A genetic disorder, such as multiple endocrine neoplasia (MEN) or congenital hypothyroidism How Are Endocrine Disorders Diagnosed? Endocrine disorders are commonly diagnosed via a combination of clinical evaluation of symptoms and medical history, blood tests, and in some cases, imaging tests, and biopsies. Typically, endocrine disorders cause a deficiency or excess of hormone, so testing for the presence or lack of sufficient hormones, and the body's ability to produce them when challenged to, is a key step in diagnosis. For example, testing for adrenal disorders can include measurement of levels of the key adrenal hormone cortisol, as well as challenge tests that measure the body's ability to produce cortisol when stimulated. Diabetes testing looks at glucose levels at a moment in time, over a longer period (such as with the Hemoglobin A1C test), and may also look at the body's ability to respond to glucose, such as in the glucose challenge test. Polycystic ovary syndrome involves a combination of blood tests to evaluate estrogen and testosterone levels, along with imaging tests to detect ovarian cysts. Endocrine disorders of the thyroid gland are typically diagnosed by clinical examination and blood tests, and in some cases, imaging tests and thyroid biopsy. What Is Autoimmune Disease? The immune system is complex, and its job is to protect us from diseases and defend against infections, including bacteria, viruses, and pathogens. With autoimmune disease, the immune system is confused, and goes on the attack against healthy cells, organs, tissue, and glands in the body as if they were infections or pathogens. Autoimmune disease is sometimes referred to as “friendly fire” by the immune system against our own body. Some of the better-known autoimmune diseases include Hashimoto’s thyroiditis, Graves’ disease, multiple sclerosis, rheumatoid arthritis, lupus, and alopecia. Causes of Autoimmune Diseases The causes of most autoimmune diseases are not well-known or understood. But experts do know that a combination of factors—genetics, toxic exposures, stress, pregnancy, nutritional deficiencies, and others—serve as a trigger in some people and can result in any one of around 80 different conditions that are considered autoimmune in nature. What Are the Symptoms of Autoimmune Disease? Autoimmune diseases can be complicated to diagnose, because in some cases, early symptoms may be vague and general, such as fatigue, muscle aches and pain, and brain fog. But the most common sign in most autoimmune conditions is inflammation, and that can cause pain, swelling, and when external, redness. Other symptoms really depend on the target of the autoimmune disease. For autoimmune thyroid disease, symptoms such as fatigue and weight changes reflect changes in thyroid function. Multiple sclerosis, which attacks the communication between muscles, can result in difficulties with coordination and walking. Rheumatoid arthritis, which attacks the joints, can cause pain and swelling in the joints, and reduced function. How Is Autoimmune Disease Diagnosed and Treated? Autoimmune disease diagnosis and treatment depends on the disease. The diagnosis process typically includes a clinical examination, family history, and blood tests as a starting point. Blood tests may measure key functions of organs that are targeted, but the key measures typically are evaluations of antibody levels, and markers and measures of inflammation and inflammatory responses in the body. In some cases, imaging tests may be performed, such as X-rays to assess joint damage in rheumatoid arthritis, or an MRI to look for brain lesions in multiple sclerosis. In some cases, biopsies may be needed to differentiate benign from cancerous lesions, cysts, nodules, or masses, or may help further detect antibodies that are not evident from blood test but are present in organs or glands. Treatment of autoimmune diseases frequently targets reduction of the inflammation, relief of related symptoms, and rebalancing of any affected hormones. In the cases of the more debilitating autoimmune diseases, modulation of the immune system to slow the rate of permanent damage to organs and tissues may be an important part of treatment. Was this page helpful? Thanks for your feedback! Losing weight with thyroid disease can be a struggle. Our thyroid-friendly meal plan can help. Sign up and get yours free! Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Clinical review: Prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review. J Clin Endocrinol Metab. 2009;94(6):1853–1878. doi:10.1210/jc.2008-2291 Yu J. Endocrine disorders and the neurologic manifestations. Ann Pediatr Endocrinol Metab. 2014;19(4):184–190. doi:10.6065/apem.2014.19.4.184 Ctvrtlik F, Koranda P, Tichy T. Adrenal disease: a clinical update and overview of imaging. A review. Biomedical Papers. 2014;158(1):023-034. doi:10.5507/bp.2014.010 Sacks DB, Arnold M, Bakris GL. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. Diabetes Care. 2011;34(6). doi:10.2337/dc11-9998 Rosenfield RL. The Diagnosis of Polycystic Ovary Syndrome in Adolescents. Pediatrics. 2015;136(6):1154-1165. doi:10.1542/peds.2015-1430 Soh SB, Aw TC. Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility. Ann Lab Med. 2019;39(1):3–14. doi:10.3343/alm.2019.39.1.3 Wang L, Wang F-S, Gershwin ME. Human autoimmune diseases: a comprehensive update. Journal of Internal Medicine. 2015;278(4):369-395. doi:10.1111/joim.12395 Additional Reading National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Fact Sheet, March 2016. http://www.niams.nih.gov/health_info/autoimmune U.S. Department of Health and Human Services. Medline Database. September 15, 2016.