Symptoms of Thyroid Disease

Thyroid disease encompasses several diagnoses. While general categories of thyroid disease symptoms—sleep changes, weight changes, bowel problems, for example—can overlap, exactly how these manifest is quite different from condition to condition. In fact, symptoms of hyperthyroidism (overactive thyroid) and hypothyroidism (underactive thyroid), the two most common types of thyroid disease, are often opposite, though they affect the same body system.

Furthermore, thyroid concerns such as goiter, thyroid cancer, and specific versions of hypothyroidism and hyperthyroidism, such as Graves' disease, can bring about other symptoms that can be unique to or more pronounced with these diagnoses.

Frequent Symptoms

Common symptoms of hypothroidism: depression, brain fog, fatigue, muscle cramps, cold intolerance, weight gain, dry skin

There is no single symptom or cluster of symptoms that lead to a definitive diagnosis of hyper- or hypothyroidism. Both can affect the same part of the body or system, but in different ways.

Weight Changes

Unexplained weight changes can be a sign of hypothyroidism or hyperthyroidism:

  • In hypothyroidism, you may be gaining weight and you may fail to lose weight despite ramping up exercise and reducing calories.
  • In hyperthyroidism, you may lose weight while eating as usual or have difficulty maintaining weight despite increased caloric intake.

Note, however, that you can be hypothyroid and losing weight, underweight, or unable to gain weight. Or, you may be hyperthyroid and find that you can't lose weight, even with a healthy diet and exercise.

Temperature Issues

Sensitivity to temperature can be a symptom of both forms of thyroid disease:

  • In hypothyroidism you may feel intolerant of the cold.
  • In hyperthyroidism you may feel hot and sweaty despite a normal environmental temperature.

Fatigue and Sleeping Problems

Sleep issues and general fatigue—which are only worsened when you don't get a good night's rest—are common complaints of people with thyroid issues. At times, they can be so profound that they greatly impact one's daily life.

Hypothyroidism or Underactive Thyroid
  • You wake up exhausted, even after eight or more hours of sleep.

  • You take long naps.

  • You have "marathon" sleep sessions on your days off.

Hyperthyroidism or Overactive Thyroid
  • You have a hard time falling asleep.

  • You wake up several times throughout the night.

  • You experience a racing heart or anxiety at bedtime.

Mental Health Problems

Depression, anxiety, and other mood disorders can be associated with thyroid problems:

  • In hypothyroidism, you may have depression symptoms or depression that doesn't respond to antidepressants.
  • In hyperthyroidism, you may experience anxiety, panic disorder, or panic attacks.

Neck or Throat Discomfort/Abnormalities

These symptoms can be associated with hyperthyroidism, hypothyroidism, autoimmune thyroid disease, nodules, goiter (an enlarged thyroid), and thyroid cancer.

  • A feeling of swelling or fullness in the neck
  • Visibly enlarged neck
  • Ear and jaw pain
  • Discomfort wearing turtlenecks or neckties
  • Difficulty swallowing or breathing
  • Tenderness in the neck
  • A hoarse, raspy voice

Neck swelling is often a symptom of thyroid disease, but it can also indicate a more serious condition, including certain types of cancers, infections, or neurological disease.

If an area of your neck is enlarged, talk to your healthcare provider about it promptly.

Hair, Skin, and Nail Changes

Hair, skin, and nails are vulnerable to thyroid hormone imbalances.

Hypothyroidism or Underactive Thyroid
  • Brittle, coarse, and dry hair

  • Hair that breaks easily

  • Loss of hair, especially on the outer edge of the eyebrows

  • Thick, dry, and scaly skin, especially on the heels/knees and elbows

  • Brittle, thin, or dull nails

Hyperthyroidism or Overactive Thyroid
  • Severe hair loss

  • Fine, thinning hair

  • Increased skin sensitivity and smoothness

  • Unusual skin rashes

Bowel Problems

The last thing you may be thinking of when you have digestive troubles is your thyroid, but gastrointestinal symptoms are common, reinforcing the far-reaching effects of this important gland:

  • In hypothyroidism, you may have severe or long-term constipation that doesn't respond to treatments or remedies.
  • In hyperthyroidism, you may have diarrhea, loose stools, or irritable bowel syndrome.

Menstrual Irregularities and/or Fertility Concerns

Thyroid conditions, especially hypothyroidism, can increase your risk of infertility, may interfere with the success of assisted reproduction treatments, and may increase the chances of recurrent miscarriage. Menstrual irregularities are also common:

  • In hypothyroidism, you may have heavier periods, painful menstruation, or less time between periods.
  • In hyperthyroidism, you may have shorter periods, lighter menstrual flow, infrequent periods, or periods may stop altogether.

Eye Problems and Vision Changes

A number of eye-related symptoms and changes are common in hypothyroidism, hyperthyroidism, and Graves’ disease.

Common symptoms include:

  • Eye dryness
  • Gritty feeling in the eye
  • Blurry vision
  • Eye redness
  • Swollen, puffy, or watery eyes
  • Sensitivity to light
  • Double vision
  • Proptosis (eye-bulging), one of the most distinctive symptoms of Graves'
  • "Lid lag"—when your upper eyelid doesn't smoothly follow movement of the eyes when you look down

Cognitive Problems

"Brain fog," a term used to describe a group of cognitive symptoms that is often used by patients and healthcare providers alike, is a symptom common to hypothyroidism specifically. Brain fog may involve:

  • Difficulty concentrating
  • Short-term and long-term memory problems
  • Forgetfulness
  • Lack of focus
  • Feeling "spaced out"
  • Confusion
  • Difficulty thinking clearly

Musculoskeletal Problems

When you're hypothyroid, you may experience aches and pains in your muscles and joints, especially in your arms and legs. Fibromyalgia-like pain is also common for people with an underactive thyroid. If you are hyperthyroid, you may have pain or unusual weakness in the upper arms, and calves. 

With hypothyroidism, there is also a greater risk of developing carpal tunnel syndrome in your hands, which can cause weakness and pain in your forearms, wrists, hands, and fingers. A similar condition, tarsal tunnel, is also a risk, causing weakness and pain in the shins, ankles, feet, and toes.

Pain is a common but often overlooked symptom of underlying thyroid issues.

Rare Symptoms

While rarer than the above, these symptoms must be considered both individually and in the context of all of the issues a patient presents with. In some cases, these could be some of the first tip-offs that a thyroid diagnosis should be investigated.


  • High cholesterol levels: If you have high cholesterol levels, especially when they are not responsive to diet, exercise, or cholesterol-lowering medications such as statins, you may have undiagnosed hypothyroidism.
  • Myxedema: This skin condition, which can occur in severe hypothyroidism, involves the deposition of mostly hyaluronic acid in the lower layer of the skin, causing coarse hair and skin, puffiness of the face or all over, tongue enlargement, and hoarseness.


  • Low cholesterol levels: Unusually low cholesterol levels that do not correlate with diet, weight, and exercise may be a sign of hyperthyroidism.
  • Graves’ ophthalmopathy: This condition is most easily recognized by proptosis, in which your eyeballs appear to be bulging and your eyes may not be completely covered when your eyelids are closed.
  • Rashes: There are two unusual rashes associated with hyperthyroidism and Graves' disease: Pretibial myxedema, also known as thyroid dermopathy, can appear on the skin of the shins. A bumpy rash known as miliaria can appear on the face.


While some of the thyroid symptoms you may be experiencing may seem more annoying than harmful, remember that your thyroid gland and the hormones it produces impact your metabolism, heart, digestion, brain, bones, and more.

Getting an early diagnosis and effectively managing your thyroid symptoms can help lower the risk of possible complications.


  • Neuropathy: Low levels of thyroid hormone can result in nerve damage, called neuropathy, characterized by tingling and numbness in the extremities. A painful foot condition known as plantar fasciitis may also develop in your feet, caused by edema (fluid buildup) around the nerves.
  • Difficulty conceiving a baby: Even mild hypothyroidism can impede ovulation and the proper implantation of an embryo, making it difficult for a woman to conceive.
  • Pregnancy complications: Hypothyroidism may put a pregnant woman at a higher risk of miscarriage, placental abruption, preterm delivery, and neonatal death. 


  • Osteoporosis: Bone weakening makes a person more prone to breaking bones with even minor bumps or falls.
  • Atrial fibrillation: This heart arrhythmia can lead to serious problems like stroke or heart failure. It is more common in older people.
  • Pregnancy complications: Moderate-to-severe hyperthyroidism in a pregnant woman can sometimes lead to preterm birth, stillbirth, and possibly congenital malformations. 

When to See Your Healthcare Provider

If you have symptoms of thyroid disease, consult with your healthcare provider, who will do a thorough physical exam, ask you details about your symptoms, and do a blood test to check your thyroid levels. Fortunately, in most cases, both hypothyroidism and hyperthyroidism can be effectively treated.

Thyroid Disease Doctor Discussion Guide

Get our printable guide for your next doctor's appointment to help you ask the right questions.

Doctor Discussion Guide Woman

Thyroid storm is a rare but very serious, potentially life-threatening condition that occurs in people with untreated hyperthyroidism. It may be triggered by a stressful event like surgery, trauma, or infection. Thyroid storm is characterized by exaggerated symptoms of hyperthyroidism, such as a very fast heart rate, high fever, diarrhea, agitation, delirium, and/or decreased consciousness.

Myxedema coma, on the other hand, is a life-threatening emergency that can result from hypothyroidism.

Read how thyroid disease causes dry mouth.

Signs of an Emergency: Myxedema Coma

Myxedema coma is a rare and life-threatening condition that may be triggered by trauma, infection, cold exposure, or certain medications. Myxedema coma causes a low body temperature and blood pressure, in addition to a loss of consciousness.

Frequently Asked Questions

  • Can I check my thyroid at home?

    There are some things you can do at home to check for thyroid conditions, including taking note of any of the symptoms presented here and speaking to your healthcare provider about them. You can also perform a thyroid "neck check" at home for lumps on the thyroid gland. A swollen thyroid gland could indicate various thyroid conditions, including nodules, goiters, or thyroid cancer.

  • Should you avoid certain foods with hyperthyroidism?

    While there is no specific diet for hyperthyroidism, it is helpful to follow certain guidelines for foods that may impact medications taken to control the condition. For example, adhering to a specific iodine intake and being mindful of soy, selenium, and cruciferous vegetables will be helpful as these may interact with thyroid medication.

  • How are thyroid issues diagnosed?

    Healthcare providers will ask you about your symptoms and medical history and then perform a physical examination of the thyroid gland. Healthcare providers also use blood tests to check for several thyroid hormones and imaging to look directly at the thyroid using a thyroid scan or ultrasound.

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9 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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