Top Causes of Death for Ages 25–44

The top causes of death for men and women in the 25–44 age group are largely preventable. Compared to ages 15–24, more chronic diseases begin to appear in this list. These illnesses are due, in part, to lifestyle factors such as exercise, diet, and stress. Still, this list of mostly preventable deaths is worth noting as changes in eating habits, physical activity, and lifestyle habits can help lower the mortality rate and add years on to your life.


A fatal car accident

​ John Clutterbuck/Getty Images

Better safe than sorry is an important adage as accidents are the leading cause of death in this age group. Knowing that 22% are from auto accidents is another cause for concern. Buckle up, drive responsibly, and put your cell phone down to save lives, including your own.

  • % of Deaths: 43.5 (22% of these are due to motor vehicle accidents)
  • Prevention Methods: Wear your seat belt, drive defensively and have a short commute.

Heart Disease

It is the leading cause of death overall in the U.S. Be vigilant in staying heart healthy by eating right, exercising, and getting proper sleep.

  • % of Deaths: 11.3
  • Prevention Methods: Relaxation, good nutrition, and exercise.


After accidents, suicide is the second leading cause of death in the 25–34 age group. Be sure to reach out to someone if you’re having trouble. There are emergency hotlines available in a crisis, but an approach to staying out of trouble is to see a counselor regularly to sort out certain issues.

  • % of Deaths: 11
  • Prevention Methods: Reduce your risk by seeking help for depression and mental illness

If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 988 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911

For more mental health resources, see our National Helpline Database.


Early detection, and thus early treatment can save a life that would've otherwise been lost to cancer. Be sure to listen to your body, get checked out quickly if you think something is wrong, perform regular self-checks, and see your healthcare provider regularly each year.

  • % of Deaths: 10
  • Prevention Methods: Eat well, exercise, and get regular check-ups.


Homicide killed more people than Covid-19 in 2020. Protect yourself and your friends by keeping an open line of communication to resolve conflicts and report any threats or suspicions to law enforcement.

  • % of Deaths: 8.1
  • Prevention Methods: Reduce your risk by seeking help for domestic violence and avoiding risky situations.


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  • % of Deaths: 5.8
  • Prevention Methods: [needs new text].

Chronic Liver Disease and Cirrhosis

Alcohol abuse is not just destructive emotionally, prolonged and regular alcohol abuse can lead to liver disease.

  • % of Deaths: 4.6
  • Prevention Methods: Drink alcohol only in moderation.


In addition to regular exercise, healthy consistent meals, and adequate sleep, be sure you see a healthcare provider if you experience tingling pain or numbness in your hands or feet. There are other pre-diabetes symptoms to watch out for as well.

  • % of Deaths: 2.8
  • Prevention Methods: Reduce your risk by eating well, avoiding excess sugar, and controlling your diabetes if you have it.


Look out for sudden numbness or weakness in one area of your body, confusion, trouble speaking or seeing or a sudden lack of coordination. These are all symptoms of a stroke.

  • % of Deaths: 1.8
  • Prevention Methods: Eat well, exercise, and take care of your heart.

Flu and Pneumonia

Surprisingly people still die from flu and pneumonia because they underestimate their illness and wait too long to seek medical attention. As soon as you have symptoms, see a healthcare provider to rule out serious health concerns.

  • % of Deaths: 1.2
  • Prevention Methods: Reduce your risk by getting a flu vaccine and washing your hands. Ask your healthcare provider if you should also get a pneumococcal vaccine, which is recommended for people with some underlying medical conditions.
2 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Centers for Disease Control and Prevention: National Center for Health Statistics. Unintentional injury for ages 25-44, United States: 2020, both sexes, all races.

  2. Centers for Disease Control and Prevention: National Center for Health Statistics. 10 Leading causes of death for ages 25-34, United States: 2020, both sexes, all races.

Additional Reading

By Mark Stibich, PhD
Mark Stibich, PhD, FIDSA, is a behavior change expert with experience helping individuals make lasting lifestyle improvements.