What To Do When You Have No Cartilage in Your Knee

When you have no cartilage in your knee, simple movements can be painful. Cartilage—a type of connective tissue that lines the end of bones—provides cushioning for joints and prevents bones from rubbing together. Severe knee cartilage loss makes walking, sitting, standing, squatting, and going up and down stairs extremely painful.

People with a total loss of knee cartilage can benefit from joint injections. In many cases, surgery including a total knee replacement is needed to treat no cartilage in the knee.

This article discusses treatments for no cartilage in the knee. It also discusses complications associated with no knee cartilage and how to prevent mild knee osteoarthritis from progressing into total cartilage loss.

Coping With Knee Cartilage Loss: Untied Shoe (Limit high impact repetitive activities), healthy food (eat a. healthy diet of whole, natural foods), hands holding (connect with others for social support), a knee and leg on top of a pillow (rest your knee), a moon (get 7-8 hours of uninterrupted sleep nightly), a weight and water (exercise and stay hydrated)

Verywell / Laura Porter

Causes of No Knee Cartilage

The most common cause of knee cartilage damage is osteoarthritis (OA), a type of arthritis caused by repetitive joint stress.

Knee cartilage can also be damaged from injuries, such as anterior cruciate ligament (ACL) ruptures, meniscus tears, and patellar (kneecap) dislocations, which increase the risk of knee OA.

If found in the early stages, knee cartilage loss is treated with conservative measures such as weight loss, exercise, pain relieving medication, and physical therapy. However, once OA progresses to having no knee cartilage left, more advanced treatments are needed.

Joint Injections

People with moderate to severe knee cartilage loss may benefit from injections directly into the joint. Options include corticosteroids, hyaluronic acid, and platelet-rich plasma (PRP). Combination intra-articular injections can also be effective for people with no knee cartilage.

Corticosteroid Injections

Corticosteroids, or cortisone injections, are anti-inflammatory medications that can be injected into the knee joint to reduce pain, swelling, and inflammation. They are the most commonly used type of knee injections for treating knee pain from osteoarthritis.

Corticosteroid injections are performed under local anesthesia, where you will be awake for the procedure but your knee will be numbed. A small amount of anesthesia will be injected into your knee before the corticosteroid, which usually begins to work two to three days later.

Corticosteroid injections can help relieve pain and reduce symptoms between six weeks and six months, although the injections are not effective for everyone. You will typically not be allowed to receive more than two or three injections per year.

Corticosteroid injections may not be recommended for patients who have diabetes or other problems with blood sugar since corticosteroid use can raise blood sugar levels.

Hyaluronic Acid

Viscosupplementation, sometimes called gel injections, refers to the use of injecting hyaluronic acid into the knee to decrease pain and improve joint movement. Hyaluronic acid used for injections is derived from the combs of chickens.

Hyaluronic acid (HLA) is a gel-like substance that occurs naturally in the synovial fluid within each joint capsule that surrounds all joints. It serves as a lubricant that allows bones to move smoothly within a joint and provides shock absorption to decrease pressure and friction within joints.

Over time, hyaluronic acid levels in the joints decrease, especially as the joints wear down with osteoarthritis.

With viscosupplementation, you may receive between one and five injections. If there is excess swelling and fluid buildup in the knee joint, your healthcare provider will use a needle to aspirate, or remove, the fluid before injecting the hyaluronic acid.

You should avoid prolonged standing, walking, jogging, running, or heavy lifting for the first 48 hours after receiving a hyaluronic acid injection.

For patients who report pain relief following hyaluronic acid injections, it may take up to four weeks to notice any significant improvement, and the lasting effects can vary from two to six months. Hyaluronic acid injections may be repeated about every six months.

Hyaluronic acid may be recommended for patients with diabetes who have knee osteoarthritis because hyaluronic acid injections do not raise blood sugar the way corticosteroids do.


Arthrosamid is a new form of viscosupplementation that involves a unique hydrogel of water molecules attached to a polyacrylamide backbone. It works by coating the lining of the synovium of the knee joint, reducing inflammation, and providing lubrication.

The injectable is a non-degradable substance, meaning the body does not break it down. Research suggests it is more effective and lasts longer than hyaluronic acid injections. In fact, some people experience up to two years of pain relief following Arthrosamid injections.

As of 2022, the treatment is available in England and other countries, but awaiting approval from the U.S. Food and Drug Administration (FDA).

Platelet-Rich Plasma

Platelet-rich plasma (PRP) injections is another technique that research shows is effective in treating knee osteoarthritis, including people with no cartilage in their knee. PRP uses concentrated blood platelets that contain growth factors. These growth factors ease pain by reducing the effect of inflammation at the cellular level.

The first step in PRP injections is having your blood drawn. The whole blood is then spun in a centrifuge to separate the plasma from red and white blood cells. This produces concentrated blood platelets that are injected into the joint in two or three places.

Initially, you will likely need a series of injections every two weeks. Once the therapeutic effect is reached the results can last up to a year.

PRP therapy is sometimes combined with gel injections with promising results. While research is limited, one study found a combination of PRP and HLA provides better and longer-lasting relief than either alone.


If more conservative treatments do not bring relief, surgery may be needed. Here is a look at surgical procedures used to treat damaged or no knee cartilage.


Knee arthroscopy is the most common type of surgical procedure performed to repair, remove, or replace damaged cartilage in the knee joint that can be causing pain and limit the range of motion of the knee joint.

During knee arthroscopy, a surgeon uses an arthroscope—a tool about the width of a pencil with a camera and light attached—to view the inside of your knee joint. This allows the surgeon to examine the inside of the knee joint without making a large incision along the outside of the knee, which is performed with open knee surgery.

Knee arthroscopy helps protect the knee joint from the risk of infection by decreasing exposure of the joint to the outside environment, and often results in an improved cosmetic appearance of the knee by reducing the size of the surgical incisions and resulting scar formation.

Knee arthroscopy also protects the surrounding knee structures, including skin, muscles, tendons, and ligaments from being damaged due to the smaller incisions.

Different types of arthroscopic knee procedures to manage the loss of cartilage include microfracture surgery, autologous chondrocyte implantation, and osteochondral autograft transplantation.


With microfracture surgery, a surgeon will use a drill to create mini fractures in the bones of the knee joint after removing an area of damaged cartilage. Creating small holes in the bone helps stimulate bone marrow cells, which can help spur the growth of new cartilage cells.

Microfracture surgery has variable outcomes since the new cartilage that forms is often fibrocartilage rather than hyaline cartilage, the type of cartilage that covers joint surfaces.

Fibrocartilage is denser and not able to withstand the same force demands as hyaline cartilage. As a result, it provides less cushioning and pressure relief and has a higher risk of breaking down after one or two years.

Autologous Chondrocyte Implantation

Autologous chondrocyte implantation involves removing cartilage cells arthroscopically and then growing them in culture in a laboratory for four to six weeks. These new cells are then reimplanted into the knee in areas of damage during another surgery to promote new growth of cartilage.

Osteochondral Autograft Transplantation

Osteochondral autograft transplantation involves removing intact cartilage cells from healthy areas of the knee joint and transplanting them to areas of damage. This procedure is typically only used in areas of focal damage localized to a specific area that is 10 to 20 millimeters in size.

Because osteochondral autograft transplantation is not used to treat widespread cartilage damage in the knee joint that is characteristic of osteoarthritis, most candidates for this type of procedure are younger than 50 years old and have cartilage damage as a result of direct knee joint trauma.

Total Knee Replacement

Approximately 54% of all Americans diagnosed with knee osteoarthritis will undergo total knee replacement to treat their symptoms.

A total knee replacement is often the last resort used to treat severe symptoms of knee osteoarthritis when the cartilage of the knee joint has significantly worn down, limiting everyday activities and making standing, walking, and going up and down stairs very challenging and painful.

During the operation, a surgeon will make a long incision down the center of the knee to access the knee joint. The kneecap will be moved aside to expose the ends of the femur, the upper leg bone, and tibia, the lower leg bone.

The ends of each bone will be shaved off and capped with metal hardware that is screwed into the leg bones. These metal components replace the damaged joint surfaces of the knee that have degenerated over time due to cartilage loss.


People in the early stages of knee osteoarthritis can often prevent further damage and a total loss of knee cartilage through conservative treatment methods. These include weight loss, braces, exercise, over-the-counter medications, and other conservative treatments.

Weight Loss

Increased body weight places an increased amount of pressure on the knee joint with weight-bearing activities like standing, squatting, walking, and going up and down stairs.

Each extra pound of weight can put up to six additional pounds of pressure on the knees with physical activity. People who are overweight also tend to develop osteoarthritis at an earlier age with greater severity of symptoms compared to those at a healthy weight.

Excessive fat cells within the body also stimulates an elevated insulin response and inflammatory processes throughout the body that increase the rate of cartilage cell degradation.

Losing extra body weight can help decrease symptoms of cartilage loss by reducing the pressure applied on the knee joints and slowing down inflammatory processes caused by metabolically disrupting fat cells.

Resistance Exercises

Research shows that strengthening the muscles around the knee joint can help to reduce joint pain, improve functioning, and slow the loss of knee cartilage. Resistance exercises that target the knee joint include:

  • Mini-squats
  • Leg extensions
  • Stair climbing

You should monitor your pain before, during, and after exercise. Do not do these exercises if you are experiencing a flare-up of pain. If you experience pain while doing exercise, stop. If your knee hurts after exercise, apply ice to reduce swelling and inflammation.


If cartilage loss is localized to one side of the knee—most commonly the inside of the knee joint—specialized, custom-made braces can help reduce pressure on the knee joint and improve the alignment of the knee.

An unloader knee brace stabilizes the knee to limit side-to-side movement while allowing the knee to bend and extend without limitation. The brace also contains three pressure points that push the knee away from the area of cartilage loss to decrease compression at the joint surface.

Knee braces are strongly recommended for the treatment of knee osteoarthritis to help decrease pain and improve function.


Over-the-counter pain-relieving medications such as acetaminophen (Tylenol) and ibuprofen (Advil) or anti-inflammatory medications like naproxen sodium (Aleve) can help reduce pain, swelling, and inflammation in the knee joint.

If symptoms are severe enough, your healthcare provider may prescribe a higher dosage of a nonsteroidal anti-inflammatory drug (NSAID) to help decrease your knee pain so you can sit, stand, and walk with less discomfort.

Physical Therapy

Physical therapy plays an important role in decreasing symptoms and preventing the progression of cartilage loss in the knees.

A physical therapist will evaluate your knee and hip alignment, muscle strength, range of motion, and movement patterns to develop an individualized plan of care to address your limitations. 

The muscles surrounding the knee help support the knee joint. When they are weak, the bones of the knee joint are subject to increased pressure and a higher risk of cartilage breakdown.

Strengthening the muscles around the knees and hips helps offload the knee joint and support your body weight so that less pressure is applied to the joint surfaces and surrounding cartilage.

Nutritional Supplements

Certain dietary supplements can help support healthy cartilage cells to protect the knee joint from wear and tear.

Glucosamine and chondroitin can help repair damaged cartilage in the hip joint and prevent enzymes from further breaking down cartilage.

Vitamin D3 is also important for maintaining good bone health and supporting immune system functioning to decrease inflammation throughout the body.


Loss of cartilage within the knee joint can result in complications affecting the integrity of the knee joint surface due to increased pressure demands, which can lead to the development of bone spurs, subchondral bone sclerosis, and cysts and lesions.

Bone Spurs

Bone spurs, called osteophytes, are outgrowths of bone that develop within joints due to increased pressure between bones from lack of cartilage. Bone spurs are common in the knee since it is a major weight-bearing joint that withstands high pressure demands.

Without adequate cartilage, the bones of the knee become irritated and inflamed due to increased pressure and friction with movement and weight-bearing of the leg. Bone cells react to this increased pressure by producing more bone growth in an attempt to provide more protection to the joint, forming bone spurs that can change the appearance of the joint and limit mobility by restricting movement.

Subchondral Bone Sclerosis

Subchondral bone is the type of bone directly under the cartilage at the ends of bones. Sclerosis is the process of abnormal hardening or stiffening of body tissues that can occur in multiple structures, such as arteries, nerves, and bones. Subchondral bone sclerosis in the knee occurs when the bones at the end of the femur and tibia that join to form the knee joint thicken as a result of becoming exposed from loss of cartilage. 

Similar to how bone spurs form, subchondral bone cells react to increased pressure within the knee joint from cartilage loss by producing more bone growth in an attempt to provide more protection to the joint. The damaged bone grows back thicker than before as the body tries to repair the damage, similar to thickened scar tissue that develops after an injury. Bone spurs are also common with subchondral bone sclerosis in addition to the subchondral bone thickening.

Cysts and Lesions

As a result of damage to subchondral bone from cartilage loss, further damage can occur to the remaining cartilage from lack of cushioning in the knee, causing lesions or tears in the remaining cartilage. Subchondral cysts—abnormal growths of fluid-filled sacs—can also develop in the subchondral bone, which may be painful and limit proper mobility of the knee joint.


Ongoing knee pain and disability from cartilage loss can be frustrating, but there are ways you can cope with an injury or conditions like osteoarthritis. Maintaining healthy lifestyle habits to reduce inflammation and stress to the joints can help make it easier to manage symptoms and prevent worsening of cartilage loss.

Ways to cope with cartilage loss include:

  • Getting at least seven to eight hours of uninterrupted sleep at night
  • Eating a healthy diet of whole, natural foods
  • Managing a healthy weight and lean body mass through diet and exercise
  • Staying adequately hydrated
  • Maintaining a positive attitude and managing stress in healthy ways
  • Staying connected to others for social support
  • Resting your knee joints to decrease pain and inflammation
  • Limiting high impact and repetitive activities that stress the knee joint, such as running and jumping

A Word From Verywell 

Loss of cartilage in the knee can cause irreversible damage to the underlying bones that form the knee joint. If you have experienced injury to the knee or are in the beginning stages of developing osteoarthritis, it is important to seek medical attention to receive guidance and treatment for managing the effects of cartilage loss and preventing progression to further damage. 

Osteoarthritis is a degenerative condition that tends to get worse over time, but by taking care of your body and strengthening the muscles that support your knee, you can help prevent further damage to your knee joint and cartilage to stay active and pain-free.

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Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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By Kristen Gasnick, PT, DPT
Kristen Gasnick, PT, DPT, is a medical writer and a physical therapist at Holy Name Medical Center in New Jersey.