Treximet (Sumatriptan and Naproxen) - Oral


Treximet contains two ingredients: sumatriptan and naproxen. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). NSAIDs cause a higher risk of serious heart/clotting events, such as heart attack and stroke, which can cause death. The risk can occur early in treatment and increase with treatment length.

NSAIDs also cause a higher risk of serious gastrointestinal (GI) problems, such as bleeding, ulcers, and perforation (holes) of the stomach or intestines. These complications can happen anytime and without warning and can cause death.

Older adults and anyone with a history of ulcers or GI bleeding are at higher risk for these serious GI events. People having coronary artery bypass (CABG) surgery should not take Treximet before or after surgery.

What Is Treximet?

Treximet (sumatriptan and naproxen) is an oral prescription drug used to treat migraine with or without aura in adults and adolescents 12 years and older. It is available as a tablet to take by mouth.

Treximet contains two ingredients. Sumatriptan is classified as a serotonin (5-HT) 1b/1d receptor agonist, also known as a triptan. It works on serotonin receptors, helping blood vessels in the brain to narrow and reducing migraine symptoms.

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing pain and inflammation.

Drug Facts

Generic Name: Sumatriptan and naproxen

Brand Name(s): Treximet

Drug Availability: Prescription

Administration Route: Oral

Therapeutic Classification: Antimigraine

Available Generically: Yes

Controlled Substance: N/A

Active Ingredient: Sumatriptan and naproxen

Dosage Form(s): Tablet

What Is Treximet Used For?

The U.S. Food and Drug Administration (FDA) approved Treximet for use in adults and adolescents 12 years and older for the acute treatment of migraine with or without aura.

Aura is a visual or sensory disturbance, such as seeing flashing lights or zigzag lines or hearing ringing in the ears. It happens before migraine pain occurs.

Limitations of Treximet include the following:

  • It should only be used in people who have been diagnosed with migraine.
  • If it does not work to alleviate migraine pain, the diagnosis of migraine should be re-evaluated before using Treximet again.
  • It does not prevent migraine.
  • It is not approved for use in cluster headache. Cluster headache is a condition where headaches frequently occur in "cluster periods," which may last from weeks to months and are followed by periods of relief.

How To Take Treximet

If you are prescribed Treximet, read the prescription label and the information leaflet that comes with it.

Use the lowest dose that treats your migraine pain. Using migraine medication too frequently can cause rebound headaches, also known as medication overuse headaches. These can occur when using migraine drugs for 10 or more days per month.

Generally, adults should not use Treximet to treat more than five headaches in 30 days. Adolescents 12 to 17 years old should not use it for more than two headaches in 30 days.

Some people must take Treximet at their healthcare provider's office for the first time. Your healthcare provider will tell you if you need to do this.

Take your medication as prescribed. The following are guidelines for how to use Treximet:

  • You can take Treximet with or without food.
  • Swallow the tablet whole with water or liquids. Do not chew, crush, or break it.
  • Take one tablet as soon as possible after you have headache symptoms.
  • If your headache does not go away, contact your healthcare provider before taking another tablet.
  • Adults: If the headache only feels slightly better, or goes away and returns, take a second tablet two hours after the first tablet. Wait at least two hours before taking a second tablet. Do not take more than two tablets in one day (24 hours). If you do not feel better, contact your healthcare provider before taking any more Treximet.
  • Adolescents 12 to 17 years old: The safety of taking a second tablet in 24 hours is unknown. People in this age group should contact their healthcare provider if the first dose does not work. Do not take a second dose.

Keep a journal to record when you get headaches and when you take Treximet. This information can help you and your healthcare provider determine how to best treat your condition.

Talk to your healthcare provider or pharmacist if you have any questions or concerns about your migraines or treatment.


Store Treximet at room temperature (between 68 F and 77 F) away from direct light, heat, and moisture. Keep the bottle tightly closed when not in use. Keep Treximet out of reach of children and pets to prevent accidental consumption.

How Long Does Treximet Take To Work?

Treximet should provide pain relief within about two hours of taking it. Your healthcare provider will tell you what to do if you are not feeling better two hours after you take Treximet.

What Are the Side Effects of Treximet?

This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your healthcare provider or a pharmacist. You may report side effects to the FDA at or 1-800-FDA-1088.

Like other medications, Treximet can cause side effects. Tell your healthcare provider about any side effects you experience while taking this medication.

Common Side Effects

Common side effects of Treximet are:

  • Dizziness
  • Dry mouth
  • Excessive sleepiness
  • Indigestion
  • Nausea
  • Numbness and tingling
  • Pain or discomfort in the chest, jaw, or neck
  • Hot flush
  • Muscle tightness

Treximet may also delay ovulation. Women who are having difficulty getting pregnant should consult their healthcare provider.

Severe Side Effects

Call your healthcare provider immediately if you have serious side effects. Dial 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Hypersensitivity reaction or anaphylaxis: Symptoms can include rash, hives, swelling around the lips, tongue, and face, and difficulty breathing.
  • Severe skin reaction: Symptoms of red or purple rash, blistering or peeling skin, sore throat, fever, or burning eyes can be life-threatening and require emergency medical attention.
  • Heart and clotting problems: This includes heart attack (be alert for chest pain that spreads to the jaw or shoulder), stroke (symptoms include sudden numbness or weakness on one side of the body, slurred speech, and shortness of breath), heart failure (symptoms include swelling, weight gain, and shortness of breath), or life-threatening arrhythmia (irregular heartbeat).
  • Serotonin syndrome: A life-threatening complication due to the buildup of excess serotonin. Symptoms may include agitation, hallucinations, fever, sweating, shivering, increased heart rate, stiff muscles, twitching, loss of coordination, and stomach problems such as nausea, vomiting, and diarrhea.
  • Stomach bleeding, ulcers, or perforation: Symptoms may include bloody/tarry stools, coughing up blood, or vomiting with a coffee-ground appearance.
  • Kidney problems: Symptoms may include less or no urination, swelling in the feet or ankles, tiredness, or shortness of breath.
  • Liver problems: Symptoms may include appetite loss, upper right stomach pain, tiredness, itching, dark urine, clay-colored stools, and yellowing of the skin or whites of the eyes (jaundice).
  • Medication overuse headaches: These can occur when Treximet is used more than 10 days per month.
  • Circulation disorders: Get medical help immediately if you have cramping, pain, heaviness, or tightness in the legs or hips, your feet or toes feel like they are burning or aching, you feel numbness and tingling in the legs, or your leg(s) or feet feel cold or change color.
  • Decreased blood flow to the small intestine: Symptoms include stomach pain, nausea, and vomiting.
  • Anemia (low red blood cell levels): Symptoms may include pale skin, tiredness, lightheadedness, and shortness of breath.
  • Raynaud phenomenon: A condition where you feel numb and cold in certain body parts, such as the fingers, toes, ears, and tip of the nose.
  • Subarachnoid hemorrhage: This involves bleeding around the brain, which requires emergency medical attention. The main symptom is a sudden, severe headache.
  • Hypertensive (high blood pressure) crisis
  • Vision loss (partial) or blindness (temporary or permanent)
  • Seizures

Long-Term Side Effects

While many people tolerate Treximet well, long-term or delayed side effects are possible. Some long-term side effects can be mild, such as:

  • Numbness and tingling
  • Ringing in the ears
  • Weight loss

Moderate long-term side effects can include:

Severe long-term side effects may include:

  • Aseptic meningitis (inflammation of the lining of the brain)
  • Bleeding inside the skull
  • Blood clots
  • Hearing loss
  • Heart attack
  • Heart failure
  • High levels of potassium
  • Kidney problems/kidney failure
  • Liver problems/liver failure
  • Pancreas inflammation
  • Seizures
  • Serotonin syndrome
  • Severe drug reactions that can cause fever, rash, facial swelling, swollen lymph nodes, and injury to the kidney or liver
  • Severe skin reaction
  • Stomach bleeding, perforation, ulcers

Report Side Effects

Treximet may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your healthcare provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Treximet Should I Take?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For migraine headaches:
      • Adults—One tablet once a day. The dose may be repeated once after waiting 2 hours. Do not take more than 2 tablets in 24 hours.
      • Children 12 to 17 years of age—One tablet once a day. Do not take more than 1 tablet in 24 hours.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.


Certain people may require a dosage change or treatment adjustment with Treximet, including:

  • Adults 65 and older with certain health conditions: Older adults have a higher risk of complications involving the heart, stomach, and/or kidneys. You may need to be more cautious with Treximet if you are in this age group and have kidney problems, high blood pressure, or are at risk for heart disease. Your healthcare provider may evaluate your cardiovascular (heart) function if other heart-related risk factors (e.g., obesity, diabetes) are present.
  • Children under 12 years old: Treximet has not been studied for this age group, so it should not be prescribed in children under 12.
  • Liver problems: People with mild or moderate liver problems can generally take Treximet but at a lower dose. However, you should not take it if you have severe liver impairment.
  • Kidney problems: Do not take Treximet if you have a creatinine clearance (CrCl) of less than 30 milliliters (mL) per minute. You may be monitored more closely if you have mild or moderate kidney problems during treatment.
  • Pregnancy: NSAIDs can be harmful to a fetus. Treximet shouldn't be used at or after 30 weeks of pregnancy. Do not take it while breastfeeding.
  • Ovulation: Treximet may delay ovulation due to its naproxen component. Talk to your healthcare provider if this is a concern for you.

Missed Dose

Because Treximet is taken only when needed, there is no regular dosing schedule. Follow the dosing instructions your healthcare provider gives, and never take more than instructed.

Overdose: What Happens If I Take Too Much Treximet?

Taking too much Treximet can cause complications.

Overdose of the sumatriptan ingredient in Treximet has caused death in animal studies. It has also been associated with the following:

  • Seizures
  • Shaking
  • Inability to move
  • Drooping eyelids
  • Redness of the extremities
  • Blue skin
  • Abnormal breathing
  • Impaired coordination
  • Dilated pupils
  • Excess flow of saliva and tears

Overdose of the naproxen ingredient in Treximet can cause:

  • Weakness
  • Drowsiness
  • Nausea or vomiting
  • Stomach pain
  • Stomach bleeds

In rare cases, high blood pressure, kidney failure, slowed breathing, and coma has occurred.

What Happens If I Overdose on Treximet?

If you think you or someone else may have overdosed on Treximet, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Treximet, call 911 immediately.


Drug Content Provided and Reviewed by IBM Micromedex®

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests will be needed to check for unwanted effects.

Check with your doctor if you have used this medicine and have not had good relief. Also, check with your doctor if your migraine headaches are worse, or if they are occurring more often, than before you started using this medicine.

Using this medicine during the later part of a pregnancy can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away.

Do not take this medicine if you have used an MAO inhibitor (MAOI) such as isocarboxazid (Marplan®), phenelzine (Nardil®), selegiline (Eldepryl®), or tranylcypromine (Parnate®) within the past 2 weeks. Do not use this medicine if you have taken other migraine medicines (eg, almotriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan, Axert™, Frova®, Amerge®, Maxalt®, or Zomig®) or an ergotamine medicine (eg, dihydroergotamine, methysergide, Cafergot®, D.H.E. 45®, Ergomar®, or Migranal®) within the past 24 hours.

This medicine may cause problems if you have heart disease. If your doctor thinks you might have a problem with this medicine, he or she may want you to take your first dose in the doctor’s office or clinic.

This medicine may increase your risk of having a blood clot, heart attack, or stroke. This is more likely to occur if you or a family member already has a heart disease, if you have diabetes, high blood pressure, high cholesterol, if you smoke, if you are male and over 40 years of age, or if you are female and have gone through menopause. People who use this medicine for a long time might also have a higher risk. Check with your doctor if you have chest pain, faintness, nausea, unusual sweating, trouble breathing, trouble seeing, or trouble speaking while using this medicine.

Check with your doctor right away if you have chest discomfort, jaw or neck tightness after using this medicine. Also, tell your doctor if you have sudden or severe stomach pain after taking this medicine.

This medicine might cause bleeding or ulcers in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (eg, steroid medicine, blood thinner).

Do not use this medicine if you are also using other medicines containing naproxen. Using these medicines together may cause serious unwanted effects.

Make sure your doctor knows about all the medicines you are using. Sumatriptan and naproxen combination may cause a serious condition called serotonin syndrome when taken with some medicines. This especially includes medicines used to treat depression, including citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, olanzapine, paroxetine, sertraline, venlafaxine, Celexa®, Lexapro®, Cymbalta®, Effexor®, Paxil®, Prozac®, or Zoloft®. Check with your doctor first before taking any other medicines.

Check with your doctor right away if you have bloody urine, a decrease in frequency or amount of urine, an increase in blood pressure, increased thirst, loss of appetite, lower back or side pain, nausea, swelling of the face, fingers, or lower legs, trouble breathing, unusual tiredness or weakness, vomiting, or weight gain. These could be symptoms of a serious kidney problem.

Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs.

This medicine may cause serious allergic reaction called anaphylaxis, which can be life-threatening and requires medical attention. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal antiinflammatory drugs (NSAIDs). Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.

Serious skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS) may also occur during treatment with this medicine. Check with your doctor right away if you have black, tarry stools, blistering, peeling, or loosening of the skin, chest pain, chills, cough, diarrhea, fever, itching, joint or muscle pain, painful or difficult urination, red irritated eyes, red skin lesions, sore throat, sores, ulcers, or white spots in the mouth or on the lips, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

Check with your doctor right away if you have any symptoms of liver problems, including dark-colored urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, or yellowing of your skin or eyes.

If you are rapidly gaining weight, having trouble breathing, chest pain or discomfort, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of heart problems or your body keeping too much water.

Using too much of this medicine or any other migraine medicines (eg, ergotamine, triptans, opioids, or a combination treatment for 10 or more days per month) may worsen your headache. Talk to your doctor about this risk. It may also be helpful to note of how often your migraine attacks occur and how much medicines you use.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your eyes may need to be checked by an ophthalmologist (eye doctor).

Drinking alcoholic beverages can make headaches worse or cause new headaches to occur. People who suffer from severe headaches should probably avoid alcoholic beverages, especially during a headache.

This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

This medicine may cause some people to become dizzy, drowsy, or less alert than normal. If any of these side effects occur, do not drive, use machines, or do anything else that could be dangerous while you are dizzy or less alert.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

What Are Reasons I Shouldn't Take Treximet?

You should not take this medication if you are allergic to sumatriptan (or any triptans), naproxen (or any NSAID), or any inactive ingredients in Treximet.

Additionally, do not use Treximet within two weeks (14 days) of taking a monoamine oxidase inhibitor (MAOI).

You should not take Treximet if you have the following:

  • Aspirin or NSAID-induced asthma or hives
  • Aspirin triad, which occurs when you have these three conditions: asthma, nasal polyps, and an allergy to aspirin
  • Coronary artery bypass graft (CABG) surgery
  • Advanced kidney disease or CrCl less than 30 mL per minute
  • Severe liver problems
  • Uncontrolled high blood pressure
  • Ischemic heart disease (heart problems caused by plaque buildup in the arteries)
  • Coronary vasospasm (sudden narrowing of an artery, which can cause heart attack, heart rhythm problems, and/or sudden death)
  • Irregular heartbeat that is associated with Wolff-Parkinson-White syndrome, an electrical abnormality in the heart
  • Peripheral vascular disease (circulation disorder)
  • Cerebrovascular disease (conditions that affect blood flow and the blood vessels in the brain)
  • Basilar migraine (also known as migraine with brainstem aura; these are headaches that start in the lower part of the brain) or hemiplegic migraine (a rare form of migraine that may mimic a stroke; the person has migraine pain along with weakness on one side of the body)
  • Ischemic bowel disease (decreased blood flow to the small intestine)
  • At least 30 weeks pregnant

Treximet may be prescribed with caution in some people only if the healthcare provider determines it is safe. This includes women who are trying to become pregnant or are in the earlier stages of pregnancy (less than 30 weeks) and people who are older and weaker.

Additionally, use caution when taking Treximet if you have the following:

  • Kidney problems
  • Heart failure
  • Recent heart attack
  • Controlled high blood pressure
  • Risk of heart disease
  • Fluid retention (swelling)
  • Sodium (salt) restriction in the diet
  • Stomach bleeding or a history of stomach ulcers
  • Cigarette smoking or alcohol use
  • Mild or moderate liver problems
  • Dehydration
  • Asthma
  • History of seizures
  • Lowered seizure threshold (increased chance of having a seizure)
  • Inflammatory bowel disease (Crohn's disease or ulcerative colitis)

Before taking Treximet, talk to your healthcare provider about your medical history, allergies to medications, and existing medical conditions.

What Other Medications May Interact With Treximet?

Tell your healthcare provider about all your medications, including prescription and over-the-counter (OTC) drugs, vitamins, or herbal supplements. You should avoid alcohol while taking Treximet.

Treximet interacts with angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) in older adults, people who are volume-depleted (low fluids in the body), or who have kidney problems. The combination can cause worsening kidney function. Treximet can also decrease the effectiveness of ACE inhibitors, ARBs, and beta-blockers in people of any age.

Examples of ACE inhibitors include:

Examples of ARBs include:

Examples of beta-blockers include Inderal LA (propranolol) and Tenormin (atenolol).

Treximet also interacts with the following:

  • Anticoagulants or antiplatelet drugs like Jantoven (warfarin), Plavix (clopidogrel), and aspirin by increasing the risk of bleeding
  • Drugs that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine inhibitors (SNRIs), by increasing the risk of serotonin syndrome
  • Diuretics, such as Microzide (hydrochlorothiazide) and Lasix (furosemide), by reducing the effect of the diuretic
  • Lanoxin (digoxin), by increasing digoxin levels in the body, which can cause serious side effects or toxicity
  • Lithium, by increasing lithium levels
  • Cyclosporine, by increasing cyclosporine levels
  • Methotrexate, by increasing methotrexate levels

Do not take Treximet at the same time as these medications:

  • Other NSAID drugs, such as aspirin or ibuprofen. This also includes salicylates such as Kaopectate or Pepto-Bismol.
  • Other triptan medications or dihydroergotamine (another migraine medication). Treximet should be separated from these migraine medications by at least 24 hours.
  • MAOI drugs such as Azilect (rasagiline), Nardil (phenelzine), Parnate (tranylcypromine), or Zyvox (linezolid). Treximet should not be taken within two weeks of taking an MAOI.

Other drug interactions may occur with Treximet. Consult your healthcare provider for a complete list of drug interactions. Also, ask your healthcare provider or pharmacist before taking medications for pain, fever, cold, or flu. Some of these products contain ingredients similar to naproxen that should not be taken with Treximet.

What Medications Are Similar?

Treximet contains a triptan called sumatriptan and an NSAID called naproxen. There are no other drugs, exactly like Treximet, that contain a triptan and an NSAID in one combination medication.

There are other forms of sumatriptan available under different brand names, including:

  • Imitrex (subcutaneous)
  • Zembrace Symtouch (subcutaneous)
  • Onzetra Xsail (nasal powder)

Triptans are commonly prescribed as a single-ingredient product to treat migraine. However, they do not prevent migraines. Triptans include:

  • Amerge (naratriptan)
  • Almotriptan
  • Frova (frovatriptan)
  • Maxalt (rizatriptan)
  • Relpax (eletriptan)
  • Zomig (zolmitriptan)

Naproxen can also be found as a single-ingredient product as an OTC drug and in higher doses by prescription. Some examples of drugs that are similar to naproxen, an NSAID, include:

NSAIDs can also be found in popular OTC migraine medications, such as Excedrin Migraine, which contains aspirin, acetaminophen (the ingredient in Tylenol), and caffeine.

There are other drugs used specifically to treat migraine pain, such as:

  • Nurtec ODT (rimegepant): An orally disintegrating tablet used to treat migraine headaches (this particular drug can also be prescribed to be taken every other day to prevent migraine)
  • Reyvow (lasmiditan): An oral tablet used to treat migraine headache
  • Ubrelvy (ubrogepant): An oral tablet used to treat migraine headache

Your healthcare provider will consider your medical history and symptoms to devise a safe and effective treatment plan for you using various methods, such as prevention, trigger avoidance, and medication.

This list is a list of drugs also prescribed for the treatment of migraine. It is NOT a list of drugs recommended to take with Treximet. Talk to your pharmacist or a healthcare provider if you have questions.

Frequently Asked Questions

  • What is Treximet used for?

    Treximet is used in adults and adolescents 12 years and older to treat migraine with or without aura. It is not used to prevent migraine, nor is it approved for use in children under 12 years old.

  • How does Treximet work?

    Treximet contains two ingredients. Sumatriptan is a triptan migraine medication that works on serotonin receptors, which helps narrow blood vessels in the brain. This reduces migraine symptoms. Naproxen is a nonsteroidal anti-inflammatory drug and works by reducing pain and inflammation.

  • What drugs should not be taken with Treximet?

    Before taking Treximet, review your medication list with your healthcare provider since there are many potential interactions. Be sure to tell your healthcare provider about all your medications, including prescription and OTC drugs, vitamins, and supplements. Some drugs that interact with Treximet include other triptans, NSAIDs, antidepressants, and certain blood pressure medications.

  • How long does it take for Treximet to work?

    Treximet is expected to provide pain relief within about two hours of taking it. Your healthcare provider will advise you on what to do if you are not feeling better two hours after you take a dose of Treximet.

  • What are the side effects of Treximet?

    Common side effects include dizziness, dry mouth, sleepiness, indigestion, nausea, numbness and tingling, and pain or discomfort in the chest, jaw, or neck. Treximet can also interfere with ovulation, so women trying to become pregnant or having difficulty getting pregnant should consult their healthcare provider. Treximet can also potentially cause several serious side effects. Before taking Treximet, discuss the risks and benefits with your healthcare provider.

  • What is medication rebound headache?

    Taking migraine medications too frequently can cause medication rebound headaches, also known as medication overuse headaches. These can occur when using migraine medication for more than 10 days per month for more than three months.

    A medication overuse headache is characterized as a headache that occurs 15 or more days per month that results from the overuse of headache medication. Usually, these headaches resolve when the medication is stopped or limited.

How Can I Stay Healthy While Taking Treximet?

Before taking Treximet, read the information leaflet carefully and consult your healthcare provider with any questions. Make sure you know how to use Treximet and what to do if the first dose does not work.

Your headache specialist probably gave you a treatment plan, including medication to prevent migraine attacks and treat migraine (such as Treximet). Ask about non-medicinal measures in addition to taking your medication to help manage attacks.

Here are some tips that can help in addition to your prescribed treatment plan:

  • Keep a journal where you can record details about migraine attacks. You can download various apps that gather a lot of information, such as when the migraine attack started and how long it lasted, other symptoms, the weather that day, and what medications you took and if they helped.
  • Seek out support groups. It can be helpful to talk to others in the same situation, whether online or in person. While speaking to others with similar experiences is helpful, remember not to take medical advice from anyone other than your healthcare provider(s).
  • Establish a regular sleep schedule. Sleep in a cool, dark, and quiet room, and avoid electronics in the bedroom.
  • Exercise for 30 to 60 minutes several times a week.
  • Eat regular, healthy meals. Avoid skipping meals, as this can trigger migraine attacks. Drink plenty of water to stay hydrated and reduce caffeine intake.
  • Seek ways to reduce stress, such as relaxation, biofeedback, and/or cognitive-behavioral therapy.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

7 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. DailyMed. Label: treximet- sumatriptan succinate and naproxen sodium tablet, film coated.

  2. Syed YY. Sumatriptan/naproxen sodium: a review in migraine. Drugs. 2016;76(1):111-121. doi:10.1007/s40265-015-0521-8

  3. Epocrates. Treximet.

  4. Prescribers’ Digital Reference. Naproxen sodium/sumatriptan - drug Summary.

  5. Becker WJ. Acute migraine treatment in adults. Headache. 2015;55(6):778-793. doi:10.1111/head.12550

  6. UpToDate. Acute treatment of migraine in adults.

  7. Vandenbussche N, Laterza D, Lisicki M, et al. Medication-overuse headache: a widely recognized entity amidst ongoing debate. J Headache Pain. 2018 ;19(1):50. doi:10.1186/s10194-018-0875-x

By Karen Berger, PharmD
Karen Berger, PharmD, is a community pharmacist and medical writer/reviewer.