Before You Buy Tylenol Cold Multi-Symptom Nighttime

Man sick in bed
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Tylenol Cold Mult-Symptom Nighttime is available to treat multiple symptoms of the cold and flu. It does contain a decongestant, unlike its competitor, NyQuil. It may be the right medication to treat the symptoms you are suffering from and help you get a good night's sleep.

Active Ingredients (in each 15ml tablespoon)

Acetaminophen 325mg (pain reliever/fever reducer)
Dextromethorphan HBr 10mg (cough suppressant)
Doxylamine succinate 6.25mg (antihistamine)
Phenylephrine HCl 5mg (decongestant)

Dosage and Directions

Adults and children over 12 years old - 2 Tablespoons (30ml) every 4 hours as needed. Do not take more than 10 Tablespoons (5 doses) in 24 hours.

Children under 12 years old - Do not use this product, contains too much Tylenol and may cause liver damage.


Temporary relief of cold and flu symptoms including:

  • Cough
  • Sore Throat
  • Headache
  • Minor Aches and Pain
  • Fever
  • Runny nose
  • Sneezing
  • Nasal Congestion

Side Effects 

Excitability may occur, especially in children (important to note this product should not be given to children under 12)

  • Warnings

    • Do not consume if you drink more than three alcoholic drinks a day. Acetaminophen can cause liver damage. Ask your doctor if you should take acetaminophen if you regularly drink more than three alcoholic drinks per day.
    • Do not use with other medications containing acetaminophen.
    • Do not use this medication if you are taking an MAOI (medication for depression, psychiatric, emotional conditions or Parkinson's disease) or for two weeks after stopping an MAOI.
    • Sore throat warning: If you have a sore throat for more than 2 days or is accompanied by fever, rash, headache, nausea or vomiting consult a doctor promptly.

    Ask a Doctor Before Use

    • If you have glaucoma
    • If you have a cough that produces a lot of mucus
    • If you have a breathing problem or chronic cough that is caused by asthma, smoking, chronic bronchitis or emphysema
    • If you have trouble urinating because of an enlarged prostate
    • If you are taking sedatives or tranquilizers
    • If you are pregnant or breastfeeding
    • If you have heart disease
    • If you have high blood pressure
    • If you have diabetes
    • If you have thyroid disease


    Stop use and ask a doctor if:
      • Pain, nasal congestion or cough worsens or lasts more than 7 days
    • Fever worsens or lasts more than 3 days
    • Redness or swelling is present in the area causing pain
    • New symptoms occur
    • Cough returns or occurs with a rash or headache that won't go away
    • Nervousness, dizziness or sleeplessness occur

    Other Information

    Do not take this product when you have to operate machinery, drive a vehicle or perform other tasks that require alertness.
    • Tylenol Cold Multi-Symptom Nighttime is likely to make you very drowsy, be sure you can devote time to sleep before taking this product.
    • All information provided on this page relates to Tylenol Cold Multi-Symptom Nighttime, Cool Burst Liquid.
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  • "Tylenol Cold Multi-Symptom Nighttime." Tylenol 1998-2015. McNeil Consumer Healthcare. 19 Feb 16.