Tymlos (Abaloparatide) - Subcutaneous

What Is Tymlos?

Tymlos (abaloparatide) is a prescription medication injected under the skin (subcutaneously) to treat osteoporosis in postmenopausal people at high risk for bone fracture.

Tymlos contains the active ingredient abaloparatide and is classified as a parathyroid hormone (PTH)-related protein.

This type of protein mimics the effects of your body’s natural PTH. As a result, Tymlos regulates the calcium level in the bones and blood, which helps strengthen and build up bones.

Tymlos is not available as a generic product. However, Tymlos, a brand-name drug, is administered by subcutaneous injection through a prefilled injector pen. Each pen contains a 30-day supply of once-daily injections.

Drug Facts

Generic Name: Abaloparatide

Brand Name(s): Tymlos

Drug Availability: Prescription

Administration Route: Subcutaneous

Therapeutic Classification: Anti-osteoporotic

Available Generically: No

Controlled Substance: N/A

Active Ingredient: Abaloparatide

Dosage Form(s): Solution for injection

What Is Tymlos Used For?

The Food and Drug Administration (FDA) approved Tymlos to treat osteoporosis in people who have gone through menopause and are at high risk for bone fracture.

Osteoporosis is a bone disease that occurs when the body loses too much bone or makes too little bone—a byproduct of menopause. As a consequence, a person's bones are more likely to break or fracture even from simple accidents.

The chances of developing osteoporosis are higher for people who have experienced menopause—the stage of a person's life marking the end of the menstrual cycle.

Menopause refers to any of the side effects you go through before or after you stop having your period. Most commonly, it happens after the age of 45.

Tymlos is meant to decrease the chance of having fractures of the spine or other bones in postmenopausal people with osteoporosis.

How to Take Tymlos

Take Tymlos at the same time each day. The timing of food does not affect your dose. It is important not to miss any doses. If you have trouble remembering, consider setting an alarm to remind you to take your dose.

Tymlos is injected into your lower abdomen. Avoid the two-inch area around your belly button.

For each injection, use a different injection site around your abdomen. Do not inject Tymlos into the same spot each day because it can lead to skin irritation.

Avoid injecting this medication into areas where your skin is tender, bruised, scaly, hard, scarred, or has stretch marks.

Keep in mind that you will need pen needles to inject Tymlos. Pen needles are sold or dispensed separately. Use a new pen needle for each dose then discard it in a sharps container.

Storage

Before using Tymlos, store it in the refrigerator between 36 to 46 degrees F.

Once you open the package and use the Tymlos pen, you may keep it at a room temperature of 68 to 77 degrees F for up to 30 days.

If applicable, keep out of reach of children and pets.

How Long Does Tymlos Take to Work?

Tymlos starts working after you take your first dose. However, it takes a while to rebuild bone. In a clinical trial, people who received Tymlos for 18 months had a significantly lower risk of having bone fractures compared to people who received a treatment that did not contain an active drug (placebo).

Also in the trial, the people who took Tymlos had increases in their bone mineral density (BMD) after 18 months of treatment.

What Are the Side Effects of Tymlos?


This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on medication side effects.

If you experience other effects, contact your pharmacist or a medical professional. You may report side effects to the FDA at fda.gov/medwatch or 1-800-FDA-1088.

Common Side Effects

Common side effects of Tymlos include:

Severe Side Effects

Call your healthcare provider right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include the following:

Long-Term Side Effects

In animal studies, Tymlos was associated with an increased risk of osteosarcoma, a type of bone cancer. It is not known if Tymlos treatment raises this risk in humans.

As a precaution, your healthcare provider will most likely limit your Tymlos treatment to a maximum of two years.

Report Side Effects

Tymlos may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your provider may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting Program or by phone (1-800-332-1088).

Dosage: How Much Tymlos Should I Take?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form (prefilled pen):
    • For osteoporosis in postmenopausal women:
      • Adults—80 micrograms (mcg) injected under the skin once a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

It is important not to miss any doses of Tymlos. Consider setting an alarm to remind you if you have trouble remembering.

Take Tymlos at the same time each day. If you miss a dose of Tymlos, consult your healthcare provider for advice on what you should do next.

Modifications

Here are some important considerations to know before beginning Tymlos:

Allergies: Avoid Tymlos treatment if you are allergic to abaloparatide or any of the other active ingredients present in Tymlos.

Pregnancy: Tymlos is not intended for use in people of childbearing age. There are no human data on Tymlos use in pregnant people to confirm any drug-associated risks.

Breastfeeding: Tymlos is not intended for use in people of childbearing age. There is no information on the presence of abaloparatide in human milk, its effects on the breastfed infant, or its effect on milk production.

Adults 65 and over: In a clinical study where 82% of people were aged 65 and over, and 19% were aged 75 and over—no overall differences in safety or effectiveness were observed between older people compared to younger people.

However, the potential for greater sensitivity to the drug in some older people cannot be ruled out.

In a different study, Tymlos was found to be safe and effective in people aged 80 years and older, and the medication’s side effects were the same as those in younger postmenopausal people.

Kidney failure: No dosage adjustment is required for patients with mild, moderate, or severe kidney impairment.

Overdose: What Happens If I Take Too Much Tymlos?

An overdose of Tymlos may cause the following symptoms:

  • Headache
  • High blood calcium levels (hypercalcemia)
  • Nausea
  • Vomiting
  • Dizziness
  • Fast heart rate (tachycardia)
  • Orthostatic hypotension

What Happens If I Overdose on Tymlos?

If you think you or someone else may have overdosed on Tymlos, call a healthcare provider or the Poison Control Center (1-800-222-1222).

If someone collapses or isn't breathing after taking Tymlos, call 911 immediately.

Precautions

Drug Content Provided and Reviewed by IBM Micromedex®

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may increase your risk of having osteosarcoma (bone cancer). This is more likely to occur if you have a history of radiation treatment involving your bones. Check with your doctor right away if you have bone pain that does not go away or a new soft tissue mass that is tender to palpation.

This medicine may cause some people to become dizzy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine may increase levels of calcium in the blood and urine. High calcium in the urine may cause kidney stones. Call your doctor right away if you have blood in the urine, confusion, constipation, dry mouth, metallic taste, muscle weakness, nausea or vomiting, pain in the side, back, or stomach, or weight loss.

What Are Reasons I Shouldn’t Take Tymlos?

You should not take Tymlos if you have had an allergic reaction to this medication or any of its ingredients in the past.

What Other Medications Interact With Tymlos?

No specific drug interactions are known to occur with Tymlos. However, that does not mean that interactions are not possible.

To help avoid potentially harmful drug interactions, tell your healthcare provider and pharmacist about all of your medications. This includes all prescription drugs, over-the-counter (OTC) medicines, vitamins, herbs, and supplements.

What Medications Are Similar?

Tymlos is a daily injection used to treat osteoporosis in postmenopausal people at high risk for bone fracture.

Examples of other treatments for osteoporosis after menopause include:

  • Forteo (teriparatide) is a daily injection used in certain adults with osteoporosis to reduce the risk of bone fracture.
  • Evista (raloxifene) is an oral tablet taken once daily to treat or prevent osteoporosis. It is also used to reduce the risk of breast cancer in high-risk people.
  • Prolia (denosumab) is an injection you receive once every 6 months. It is used to treat osteoporosis. It can also be used to treat bone loss caused by cancer treatments.
  • Reclast (zoledronic acid) is given as an intravenous (IV) infusion. It is given every 12 months to treat osteoporosis or every 24 months to prevent osteoporosis.
  • Fosamax (alendronate) is an oral tablet that’s typically taken once weekly to treat osteoporosis. It belongs to a drug class called bisphosphonates
  • Ibandronate is also a bisphosphonate. It is most commonly prescribed as a once-monthly oral tablet to treat osteoporosis. An IV form of ibandronate is also available.

Ask your pharmacist or a healthcare practitioner if you have questions about alternatives to Tymlos. Additionally, your provider may recommend that you take calcium and vitamin D supplements to support healthy bones.

This is a list of drugs also prescribed for osteoporosis. It is not a list of drugs recommended to take with Tymlos.

In fact, you should not take these drugs together. Talk to your pharmacist or a healthcare provider if you have questions.

Frequently Asked Questions

  • How does Tymlos work?

    Tymlos works by mimicking the effects of PTH. PTH is naturally made by the parathyroid glands in your neck. This hormone helps regulate calcium levels in your bones and blood. It helps your body rebuild and strengthen bones.

  • How long can I take Tymlos?

    In clinical trials, people took Tymlos for 18 months. Your provider will likely recommend a maximum of 18 to 24 months of treatment.

    It is not known if longer-term use is safe, due to the increased risk of osteosarcoma seen in animal studies of the drug.

  • Is there a lower-cost generic version of Tymlos?

    There currently is no generic version of Tymlos. It only comes as a brand-name medication. To see if you can lower your cost, check with the drug’s manufacturer to see if you qualify for any of their coupons or savings programs.

  • Is Tymlos safe for older people?

    Yes. In a clinical study, Tymlos was found to be safe and effective in people aged 80 and older. The medication’s side effects were the same as those seen in younger postmenopausal people.

How Can I Stay Healthy While Taking Tymlos?

Tylmos has been shown to significantly increase bone density and improve overall bone strength.

After you complete Tymlos treatment, your healthcare provider will likely have you take a different osteoporosis medication, such as Fosamax (alendronate).

Besides taking medications, a healthy lifestyle is important to support strong bones.

This includes eating a balanced diet, taking calcium and vitamin D supplements, and exercising. Your healthcare provider can tell you more about which types of exercises are safe for you.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended to replace medical advice, diagnosis, or treatment from a healthcare provider. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content, as indicated on the page.

10 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. National Library of Medicine, MedlinePlus. Abaloparatide injection.

  3. National Library of Medicine, MedlinePlus. Osteoporosis.

  4. National Library of Medicine, MedlinePlus. Menopause.

  5. Prescribers' Digital Reference. Abaloparatide - drug summary.

  6. McClung MR, Harvey NC, Fitzpatrick LA, et al. Effects of abaloparatide on bone mineral density and risk of fracture in postmenopausal women aged 80 years or older with osteoporosis. Menopause. 2018;25(7):767-771. doi:10.1097/GME.0000000000001080

  7. Tella SH, Gallagher JC. Prevention and treatment of postmenopausal osteoporosisJ Steroid Biochem Mol Biol. 2014;142:155-170. doi:10.1016/j.jsbmb.2013.09.008

  8. Brent MB. Abaloparatide: a review of preclinical and clinical studiesEur J Pharmacol. 2021;909:174409. doi:10.1016/j.ejphar.2021.174409

  9. National Library of Medicine, MedlinePlus. Alendronate.

  10. National Institute on Aging. Menopause: Tips for a Healthy Transition.

By Patricia Weiser, PharmD
Patricia Weiser, PharmD, is a licensed pharmacist and freelance medical writer. She has more than 14 years of professional experience.