How a Urinary Tract Infection Is Treated

Urinary tract infections (UTIs) are often mild and can sometimes resolve on their own with nothing more than ample fluids and maybe a mild over-the-counter (OTC) pain reliever. However, if lasting for more than two days, you may benefit from a short course of antibiotics. This is especially true if the infection has moved from your bladder to your kidneys. In instances like these, home remedies and analgesics are unlikely to provide relief and may increase your risk of complications.

Home Treatment Tips for a Urinary Tract Infection
Verywell / Brianna Gilmartin

Home Remedies

While antibiotics are commonly prescribed to treat a urinary tract infection, attitudes have changed in recent years due to increasing rates of antibiotic-resistant E. coli and other bacteria. Today, some healthcare providers will take a watch-and-wait approach if a UTI is uncomplicated and has minor symptoms.

In Europe, for example, healthcare providers will often provide a 48-hour delayed prescription to be used at the patient's discretion. Similar practices are being adopted by some healthcare providers in the United States.

Some studies suggest that withholding antibiotics may result in a higher risk of UTI complications, and most experts have not adopted this practice.

To minimize the need for antibiotics when dealing with a minor UTI, there are a number of tried-and-true remedies to turn to:

  • Drink plenty of water. Simply by keeping the urinary tract working, you'll be able to clear out more of the circulating bacteria in the bladder or kidneys. Aim to drink no less than eight glasses of water a day (or roughly half a gallon). During an active infection, you may want to up that to as many as 16, if appropriate. The aim is to urinate and urinate often, never holding it in and going as often you need to.
  • Drink cranberry juice. Long lauded for its ability to treat UTIs, cranberry juice contains compounds thought to prevent bacteria from sticking to the walls of the urinary tract. While some scientists have publicly doubted these claims, research from Boston University School of Medicine concluded that a daily, eight-ounce glass of cranberry juice, taken over 24 weeks, reduced the recurrence of UTIs by nearly 45 percent.
  • Increase your intake of vitamin C. Vitamin C may help treat a mild urinary tract infection by increasing urine acidity and making it less accommodating to bacteria. If needed, you can bolster your intake through food with a daily supplement.

By contrast, you should avoid any food or drink that can irritate the urinary tract and/or inflame the symptoms. This includes spicy foods, alcohol, caffeine, and citrus.

Placing a heating pad, hot water bottle, or warm compress on your abdomen or back can help to ease the discomfort of a bladder infection.

Over-the-Counter Therapies

Over-the-counter drugs are mainly used to alleviate discomfort and pain of a UTI. Chief among these are nonsteroidal anti-inflammatory drugs (NSAIDs) like Advil (ibuprofen) or analgesic pain relievers like Tylenol (acetaminophen). But such medications should not be a replacement for antibiotics.

Another drug, known as phenazopyridine, is designed specifically to treat urinary tract pain. It is available in lower doses without a prescription and marketed under such brand names as Azo or Uristat.

Higher strength formulations are available by prescription and are commonly taken to reduce pain until such time as antibiotics are able to control the infection. You would need to avoid alcohol when taking phenazopyridine, as it could cause liver toxicity. Common side effects include drowsiness, increased thirst, stomach ache, fatigue, nausea, and vomiting.


While some may be eager to get antibiotics to address their symptoms, these drugs should only be prescribed by healthcare providers when needed (and for the shortest amount of time necessary) and used properly to reduce the risk of drug resistance.

The vast majority of UTIs are caused by bacteria and, as such, are treated with antibiotics. The choice of drug is largely dependent on whether the infection is in the bladder (cystitis) or the kidneys (pyelonephritis).

Cystitis Treatment

The first-line antibiotic drugs used for the treatment of uncomplicated cystitis include:

  • Trimethoprim-sulfamethoxazole (TMP-SMX)
  • Nitrofurantoin monohydrate
  • Fosfomycin

Symptoms of cystitis will typically resolve within six days of starting treatment. Treatment may take longer if you have recurrent UTIs or have severe urinary tract symptoms. Common side effects include a headache, dizziness, stomach upset, fatigue, nausea, vomiting, itchiness, and rash.

Nitrofurantoin and fosfomycin should be avoided if there are any signs of a kidney infection, including flank pain, fever, nausea, vomiting, and chills.

Pyelonephritis Treatment

Around 90% of acute kidney infections can be treated with oral antibiotics. The most commonly prescribed ones include:

  • Fluoroquinolones (such as ciprofloxacin and levofloxacin)
  • Cephalosporins
  • Penicillin
  • Amoxicillin
  • Augmentin (amoxicillin-clavulanate potassium)

People with milder infections may only require treatment for five to seven days. By contrast, pregnant women may require a seven- to 14-day course, while immune-compromised people may require up to 21 days of treatment. Severe cases may require a combination of intravenous (IV) and oral antibiotics.

Research so far hasn't shown that fluoroquinolones are unsafe during pregnancy, but better studies are needed. To be on the safe side, some experts recommend that these drugs should not be used as a first-line therapy.

Side effects of the recommended antibiotics are much the same as those used for cystitis. However, certain drugs (like penicillin) may cause a potentially life-threatening, whole-body allergy known as anaphylaxis. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, and death.

Complementary Medicine (CAM)

While a number of alternative approaches have been proposed to either treat or prevent a urinary tract infection, the evidence on them to date has been lacking.

Some, such as probiotics, have not demonstrated the same benefits to urinary tract as they have other organ systems. Others, like zinc supplements used to support UTI therapy, have been shown to increase the risk of urinary tract complications.

Other folk remedies such as garlic, horseradish, nasturtium, and Salvia plebeia—used in traditional Chinese medicine (TCM)—have shown little to no benefit in treating or preventing UTIs in few available studies researching their use.

As stated above, cranberry juice is an option you might consider. Cranberry supplements, typically available in caplet formulations, are also available.


One nutritional supplement that has attracted attention in recent years is a simple sugar derived from cranberries and other plants known as D-mannose. Unlike most sugars, D-mannose does not readily enter the bloodstream and is quickly excreted from the body, unchanged, in 30 to 60 minutes.

Because D-mannose remains unmetabolized, it does not raise blood glucose levels in the same way as other sugars. Instead, it binds to the lining of the intestinal tract and prevents bacteria from attaching to and infecting epithelial cells.

While there is no evidence that D-mannose can treat a urinary tract infection, a 2014 study published in World Journal of Urology found that women who took D-mannose powder daily had a lower rate of UTI recurrence compared to those who took a placebo.

Furthermore, the daily use of D-mannose appeared to be just as effective in preventing UTI recurrence as the daily use of the antibiotic drug nitrofurantoin.

With that being said, D-mannose supplements can cause bloating, loose stools, and diarrhea. When taken in excessive doses, there also concerns that D-mannose may lead to kidney damage. As such, you speak with your healthcare provider before taking this or any other OTC remedy, supplement, or herbal medication.

Frequently Asked Questions

  • How do healthcare providers diagnose UTI?

    A urine test is usually the first step for diagnosing a UTI, and the urine will be analyzed for bacteria and white blood cells. If the urine tests positive for a UTI and symptoms persist after treatment, imaging tests can be used to determine other potential issues in the urinary tract.

  • How do you prevent UTIs?

    According to the CDC, there are several tips to help prevent UTIs, including urinating after sex, drinking lots of fluids, taking showers rather than baths, always wiping front to back (females), and avoiding douching or using any sprays or powders near the genitals.

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22 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Bono MJ, Reygaert WC. Urinary Tract Infection. [Updated 2019 Dec 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from:

  2. Shigemura K, Kitagawa K, Osawa K, et al. Comparison of antibiotics use, urinary tract infection (UTI)-causative bacteria and their antibiotic susceptibilities among 4 hospitals with different backgrounds and regions in JapanJ Chemother. 2018;30(1):31–36. doi:10.1080/1120009X.2017.1376817

  3. Little P, Moore MV, Turner S, et al. Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trialBMJ. 2010;340:c199. Published 2010 Feb 5. doi:10.1136/bmj.c199

  4. Hooton TM, Vecchio M, Iroz A, et al. Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical TrialJAMA Intern Med. 2018;178(11):1509–1515. doi:10.1001/jamainternmed.2018.4204

  5. Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2012;10:CD001321. doi:10.1002/14651858.CD001321.pub5.

  6. Maki KC, Kaspar KL, Khoo C, Derrig LH, Schild AL, Gupta K. Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. Am J Clin Nutr. 2016;103(6):1434-42. doi:10.3945/ajcn.116.130542

  7. Ochoa-Brust GJ, Fernández AR, Villanueva-Ruiz GJ, Velasco R, Trujillo-Hernández B, Vásquez C. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancyActa Obstet Gynecol Scand. 2007;86(7):783–787. doi:10.1080/00016340701273189

  8. Maserejian NN, Wager CG, Giovannucci EL, Curto TM, McVary KT, McKinlay JB. Intake of caffeinated, carbonated, or citrus beverage types and development of lower urinary tract symptoms in men and womenAm J Epidemiol. 2013;177(12):1399–1410. doi:10.1093/aje/kws411

  9. Afazel MR, Jalali E, Sadat Z, Mahmoodi H. Comparing the effects of hot pack and lukewarm-water-soaked gauze on postoperative urinary retention; a randomized controlled clinical trialNurs Midwifery Stud. 2014;3(4):e24606. doi:10.17795/nmsjournal24606

  10. Foxman B, Buxton M. Alternative approaches to conventional treatment of acute uncomplicated urinary tract infection in womenCurr Infect Dis Rep. 2013;15(2):124–129. doi:10.1007/s11908-013-0317-5

  11. Pergialiotis V, Arnos P, Mavros MN, Pitsouni E, Athanasiou S, Falagas ME. Urinary tract analgesics for the treatment of patients with acute cystitis: where is the clinical evidence?Expert Rev Anti Infect Ther. 2012;10(8):875–879. doi:10.1586/eri.12.72

  12. National Center for Biotechnology Information. PubChem Database. Phenazopyridine hydrochloride, CID=8691, (accessed on Apr. 22, 2020)

  13. Centers for Disease Control and Prevention. Antibiotic Prescribing and Use in Doctor's Offices. Adult Treatment Recommendations. Updated October 3, 2017.

  14. Gardiner BJ, Stewardson AJ, Abbott IJ, Peleg AY. Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problemsAust Prescr. 2019;42(1):14–19. doi:10.18773/austprescr.2019.002

  15. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 91: Treatment of urinary tract infections in nonpregnant womenObstet Gynecol. 2008;111(3):785–794. doi:10.1097/AOG.0b013e318169f6ef

  16. Yefet E, Schwartz N, Chazan B, Salim R, Romano S, Nachum Z. The safety of quinolones and fluoroquinolones in pregnancy: a meta-analysisBJOG. 2018;125(9):1069-1076. doi:10.1111/1471-0528.15119

  17. Ring J, Beyer K, Biedermann T, et al. Guideline for acute therapy and management of anaphylaxis: S2 Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Association of German Allergologists (AeDA), the Society of Pediatric Allergy and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Society for Psychosomatic Medicine (DGPM), the German Working Group of Anaphylaxis Training and Education (AGATE) and the patient organization German Allergy and Asthma Association (DAAB). Allergo J Int. 2014;23(3):96–112. doi:10.1007/s40629-014-0009-1

  18. Johnson AR, Munoz A, Gottlieb JL, Jarrard DF. High dose zinc increases hospital admissions due to genitourinary complicationsJ Urol. 2007;177(2):639–643. doi:10.1016/j.juro.2006.09.047

  19. Domenici L, Monti M, Bracchi C, et al. D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci. 2016;20(13):2920-5.

  20. Altarac S, Papeš D. Use of D-mannose in prophylaxis of recurrent urinary tract infections (UTIs) in womenBJU Int. 2014;113(1):9–10. doi:10.1111/bju.12492

  21. Urology Care Foundation. What is a urinary tract infection (UTI) in adults? Updated April 2019.

  22. Centers for Disease Control and Prevention. Urinary tract infection. Updated August 27, 2019.

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