HIV/AIDS Treatment Print Vitekta (elvitegravir) - HIV Drug Information Drug Prevents HIV from Hijacking a Cell's Genetic Machinery By James Myhre and Dennis Sifris, MD Updated September 27, 2016 Medically reviewed by a board-certified physician Image courtesy Gilead Science More in HIV/AIDS Treatment Causes & Risk Factors Diagnosis Living With Support & Coping Prevention Related Conditions History Symptoms View All Classification Vitekta (elvitegravir) is an antiretroviral drug classified as an integrase inhibitor which is used in the treatment of HIV. Integrase inhibitors work by blocking an HIV enzyme called integrase, which HIV uses to integrate its genetic coding into the host cell's DNA. By blocking integrase, the virus is unable to complete its life cycle and create other HIV virions. Vitekta was approved by the U.S. Food and Drug Administration (FDA) in September 2014 for use in adults previously exposed to HIV therapy. Elvitegravir is a component of the fixed dose combinations drug Stribild (also popularly known as the "Quad Pill") and the second-generation version of Stribild called Genvoya. Drug Formulation Vitekta is available in two tablet formulations: An 85 mg pentagon-shaped, film-coated tablet, green in color with "GSI" embossed on one side and "85" on the other.A 150 mg triangle-shaped, film-coated tablet, green in color with "GSI" embossed on one side and "150" on the other. Dosage Vitekta must always be used in combination therapy with both an HIV protease inhibitor (PI) and Norvir (ritonavir), a "boosting" agent which extends the concentration of the accompanying drugs in the blood. Vitekta must be taken with food. The recommended dosage varies by drug selection as follows: Vitekta dosage Protease Inhibitor dosage Norvir (ritonavir) dosage 85mg once daily Reyataz (atazanavir) 300mg once daily 100mg once daily 85mg once daily Kaletra (400mg lopinavir + 100 mg ritonavir) twice daily Not required as ritonavir is already contained in Kaletra formulation 150mg once daily Prezista (darunavir) 600mg twice daily 100mg twice daily 150mg once daily Lexiva (fosamprenavir) 700mg twice daily 100mg twice daily 150mg once daily Aptivus (tipranavir) 500mg twice daily 200mg twice daily Common Side Effects In Phase III human clinical studies, a number of potential drug side effects have been identified in patients taking Vitekta. The most common events, reported in at least 2% of the trial participants include: DiarrheaNauseaHeadache Less common side effects include abdominal pain, indigestion, rash, fatigue and vomiting.Side effects were generally transient, with few patients discontinuing as a result of treatment intolerance. Drug Contraindications Vitekta should not be taken with the following drugs or herbal supplements: Hepatitis C medication: Invicek, VictrelisRifampin-based anti-tuberculosis medications: Rifater, Rifamate, Rimactane, Rifadin, Priftin (substitute with Mycobutin)St. John's Wort Always inform your doctor of any drug or supplement, prescribed or non-prescribed, that you may be taking before starting any antiretroviral therapy. Antiretroviral Drug Interactions The use of Vitekta with following antiretroviral drugs may result either in the loss of therapeutic effect of the accompanying drug or an increase of side effects: Sustiva (efavirenz) should not be coadministered with Vitetkta.Viramune (nevirapine) should not be coadministered with Vitekta.Videx (didanosine) should either be taken one hour before or two hours after a Vitekta dose.Tybost (cobicistat), a boosting agent similar to Norvir, should not be taken with Vitekta when coadministered with a protease inhibitor. Other Considerations Antacids can prevent Vitekta from being properly absorbed. If you are using an over-the counter antacid (e.g. Rolaids, Tums, Milk of Magnesia), it is suggested that it be taken either two hours before or after a dose of Evotaz. Women should advise their doctor if they are taking or planning to take birth control pills. Vitekta, when used with Norvir, can significantly reduce the plasma concentration of ethinyl estradiol /norgestimate hormonal contraceptives. Alternative methods of non-hormonal contraception are recommended. Never increase hormonal contraceptive dosages. It is advised that nursing mother not breastfeed if they are HIV positive as it potentially transmit the virus to the infant. Vitekta contains lactose so be sure to advise your doctor if you are lactose intolerant. Was this page helpful? Thanks for your feedback! Get information on prevention, symptoms, and treatment to better ensure a long and healthy life. Email Address Sign Up There was an error. Please try again. Thank you, , for signing up. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Sources: FDA. "FDA approves new combination pill for HIV treatment for some patients." Silver Spring, Maryland; press release issued on August 27, 2012. Gilead Sciences. "Genvoya - Highlights of Prescribing Information." Foster City, California; accessed December 14, 2015. U.S. Food and Drug Administration (FDA). "VITEKTA - FULL PRESCRIBING INFORMATION." Silver Srpring,Maryland; accessed February 3, 2015. Continue Reading Facts About Stribild, the HIV "Quad Pill" Treating HIV With Evotaz (Atazanavir/Cobicistat) Improved Four-in-One Tablet Promises Lower Risk of Toxicities Complera - HIV Antiretroviral Drug Information How the HIV Drug Isentress Works Treating HIV with Odefsey Facts About Tivicay (Dolutegravir) for Treatment of HIV Understanding the HIV Life Cycle How HIV Booster Drugs Work There Are Once a Day HIV Meds That Are Very Good Treatment Choices What You Should Know About Zepatier for Treating Hepatitis C 3 OTC Drugs That Undermine HIV Therapy 6 Drugs to Avoid If Taking HIV Therapy How HIV Is Treated With Atripla When Did HAART Become ART? How Much Adherence Is Enough for Newer Generation HIV Drugs?