Vyndamax (Tafamidis) - Oral

What Is Vyndamax?

Vyndamax, also known as tafamidis, is a prescription oral medication used to treat cardiomyopathy caused by a rare disease known as transthyretin amyloid (ATTR).

Tafamidis works by binding to and stabilizing a normal protein produced in your liver known as transthyretin (TTR ). In ATTR, this protein becomes folded incorrectly, which can cause problems with the heart and other organ systems. Vyndamax slows down the process of this protein incorrectly folding.

Vyndamax is available in capsule form.

Drug Facts

Generic Name: Tafamidis

Brand Name(s): Vyndamax, Vyndaqel

Drug Availability: Prescription

Administration Route: Oral

Therapeutic Classification: Transthyretin stabilizer 

Available Generically: No

Controlled Substance: N/A

Active Ingredient: Tafamidis

Dosage Form(s): Capsule

What Does Vyndamax Treat?

The Food and Drug Administration (FDA) approved Vyndamax to treat transthyretin amyloid cardiomyopathy (ATTR-CM) and reduce the risk of heart-related hospitalization or death.

How to Take Vyndamax

You should always follow directions given to you by your healthcare provider on how to take Vyndamax. The usual dose of Vyndamax is one capsule daily. Swallow the capsules whole; do not crush or cut them.

Storage

Store Vyndamax in a cool, dry place. In general, medications should be kept away from areas exposed to heat or humidity, like above the stove or in your bathroom. Also, keep Vyndamax away from bright light. These environments can impact how well medications work.

It is also important to ensure this medication is kept away from children and pets to prevent accidental consumption.

Generally, it is best to contact your pharmacist before you run out of the medication to put in a refill request.

How Long Does Vyndamax Take to Work?

Vyndamax is a medication that is quickly absorbed in your body, with max concentrations observed two hours after taking it. On average, Vyndamax takes 14 days to reach a steady state in the bloodstream and to see its full effects.

What Are the Side Effects of Vyndamax?

This is not a complete list of side effects, and others may occur. A healthcare provider can advise you on side effects. If you experience other effects, contact your healthcare provider or a pharmacist. You may report side effects to the FDA at FDA.gov/MedWatch or 800-FDA-1088.

Common Side Effects

Vyndamax is a generally well-tolerated medication. Though there are no well-documented side effects, one study found that Vyndamax may slightly increase the risk of urinary tract infection (UTI).

Severe Side Effects

Vyndamax is a relatively safe medication, and no severe side effects have been reported. You should contact your healthcare provider immediately if you experience a severe allergic reaction to the medication.

Long-Term Side Effects

Vyndamax is a well-tolerated medication that does not have documented side effects that occur after it has been stopped.

Report Side Effects

Vyndamax may cause other side effects. Call your healthcare provider if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your healthcare provider may send a report to the FDA's MedWatch Adverse Event Reporting Program or by phone (800-332-1088).

Dosage: How Much Vyndamax Should I Take?

Drug Content Provided and Reviewed by IBM Micromedex®

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For cardiomyopathy:
      • Adults—
        • Vyndamax™: 61 milligrams (mg) (1 capsule) once a day.
        • Vyndaqel®: 80 mg (four 20 mg capsules) once a day.
      • Children—Use and dose must be determined by your doctor.

Modifications

Do not take Vyndamax if you are pregnant due to the potential for fetal harm. Also, do not breastfeed while you are taking it

You should speak with your provider if you have any questions on dosage or use.

Missed Dose

If you miss a dose of Vyndamax, take it as soon as you remember. If the time when you remember happens to be close to the next scheduled dose, only take the upcoming scheduled dose. Do not take two doses at the same time.

Overdose: What Happens if I Take Too Much Vyndamax?

There is limited data on what happens if you overdose on this medication.

During clinical trials, two patients accidentally took a high dose without any side effects. In another trial, a high dose was taken and resulted in a stye. In case of an overdose, seek medical help immediately and contact poison control for the latest recommendations.

What Happens if I Overdose on Vyndamax?

If you think you or someone else may have overdosed on Vyndamax, call a healthcare provider or the Poison Control Center (800-222-1222).

If someone collapses or isn't breathing after taking Vyndamax, call 911 immediately.

Precautions

Drug Content Provided and Reviewed by IBM Micromedex®

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine. If you think you have become pregnant while using this medicine, tell your doctor right away.

Patients who use this medicine may register for the Transthyretin Amyloidosis Outcome Survey (THAOS), which may be used to inform and educate patients and healthcare professionals about the disease and its management. This may involve long-term follow-up.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

What Are Some Reasons I Shouldn’t Take Vyndamax?

Do not take Vyndamax if any of the following applies to you:

  • If you are pregnant, due to the risk of fetal harm
  • If you are currently breastfeeding your child

What Other Medications Interact With Vyndamax?

Vyndamax inhibits a specific protein that removes certain medications and substances in your body. This inhibition can lead to higher levels of the following medications that are removed by the specific protein.

You should talk to your healthcare provider to see if you may need dose adjustments to any of these medications.

What Medications Are Similar?

The active ingredient in Vyndamax is currently the only FDA-approved medication that treats ATTR cardiomyopathy. Along with Vyndamax, there is another medication with tafamidis as the active ingredient known as Vyndaqel. These medications differ in the form of tafamidis that they contain. 

ATTR is a disease that can also lead to nerve pain throughout the body. Though Vyndamax is only approved for heart problems associated with ATTR, other medications may treat this nerve pain, such as:

  • Tegsedi (inotersen)
  • Onpattro (patisiran)

This is a list of drugs also prescribed for ATTR. It is not necessarily a list of drugs recommended to take with Vyndamax. Talk to your pharmacist or a healthcare provider if you have questions about your treatment plan.

Frequently Asked Questions

  • Where can I get Vyndamax?

    Vyndamax is a specialty medication. Therefore, you will not be able to get it from a regular pharmacy. You may pick up the medication at a specialty pharmacy, or the specialty pharmacy may mail the medication to you.

  • Is there a way to help me save on Vyndamax?

    Vyndamax is a relatively expensive medication and currently has no lower-cost generic available. Though the medication may be expensive, there may be a savings program available from the manufacturer that could potentially lower the cost of your Vyndamax medication. Talk to your healthcare provider or pharmacist about potential financial assistance options.

  • How does Vyndamax work?

    Vyndamax acts on a specific protein in the body made by the liver. In some people, this protein may become folded incorrectly and form clumps that can damage parts of the body, including the heart. This is known as transthyretin amyloid (ATTR), which is a disease of the specific protein folding incorrectly. Vyndamax binds to this protein and stabilizes it. By doing so, it slows down the progression of the disease, ultimately preventing damage to the heart.

  • What are the side effects of Vyndamax?

    Vyndamax is a well-tolerated medication that has very few side effects. Studies have shown that the most common side effects of Vyndamax are diarrhea, increased risk of getting the flu, and increased risk for urinary tract infections (UTIs).

How Can I Stay Healthy While Taking Vyndamax?

To stay healthy while taking Vyndamax, take this medication as directed by your healthcare provider. It is also generally recommended to eat a healthy diet, exercise as tolerated, and stay well hydrated.

Medical Disclaimer

Verywell Health's drug information is meant for educational purposes only and is not intended as a replacement for medical advice, diagnosis, or treatment from a healthcare professional. Consult your healthcare provider before taking any new medication(s). IBM Watson Micromedex provides some of the drug content as indicated on the page.

The author would like to recognize and thank Cody Ryan Thomas for contributing to this article.

5 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. DailyMed. Label: Vyndaqel- tafamidis meglumine capsule, liquid filled. Vyndamax- tafamidis capsule, liquid filled.

  2. Cho Y, Baranczak A, Helmke S, et al. Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy). Amyloid. 2015;22(3):175-180. doi: 10.3109/13506129.2015.1063485.

  3. Coelho T, Merlini G, Bulawa CE, et al. Mechanism of action and clinical application of tafamidis in hereditary transthyretin amyloidosis. Neurol Ther. 2016;5(1):1-25. doi:10.1007/s40120-016-0040-x.

  4. Huber P, Flynn A, Sultan MB, et al. A comprehensive safety profile of tafamidis in patients with transthyretin amyloid polyneuropathy. Amyloid. 2019;26(4):203-209. doi:10.1080/13506129.2019.1643714.

  5. Urits I, Swanson D, Swett MC, et al. A review of patisiran (Onpattro) for the treatment of polyneuropathy in people with hereditary transthyretin amyloidosis. Neurol Ther. 2020;9(2):301-315. doi:10.1007/s40120-020-00208-1