Blood Disorders Platelet Function Disorders Overview Symptoms, Causes, Diagnosis, Treatment By Amber Yates, MD Amber Yates, MD LinkedIn Twitter Amber Yates, MD, is a board-certified pediatric hematologist and a practicing physician at Baylor College of Medicine. Learn about our editorial process Updated on June 16, 2022 Medically reviewed by Brian H. Wetchler, DO Medically reviewed by Brian H. Wetchler, DO Brain H. Wetchler, DO, is a board-certified internal medicine physician. He works in private practice at Woodmere Medical Associates in New York. Learn about our Medical Expert Board Print Platelet function disorders are a group of bleeding disorders in which the platelets do not function appropriately, leading to bleeding. These disorders can be inherited (passed down in families) or acquired (developed after birth). Science Photo Library/Creative RF/Getty Images Symptoms Platelets are one part of our clotting system, the system that helps us stop bleeding. If your platelets don't function properly, you are at an increased risk of bleeding. MedlinePlus reports symptoms include: Increased bruising Nosebleeds Gum bleeding Menorrhagia (excessive menstrual bleeding) Prolonged bleeding after a cut or other injury Prolonged bleeding with surgery Causes As noted, platelet function disorders can be divided into categories including congenital (inherited) or acquired. The National Hemophilia Foundation reports some platelet disorders remain undiagnosed due to lack of medical knowledge, however, the main types include: Glanzmann's thrombastheniaBernard-Soulier syndromePlatelet storage pool disease Some, but not all, acquired causes can include the following, according to MedlinePlus. Idiopathic thrombocytopenic purpura Multiple melanomaPrimary thrombocythemia Medications including aspirin, ibuprofen, other anti-inflammatory drugs, penicillin, phenothiazines, and prednisone (after long-term use)Kidney (renal) failure Diagnosis As opposed to other platelet disorders, which are often issues with platelet number (elevated or decreased), platelet function disorders may have normal platelet counts. Other types of platelet function disorders can have thrombocytopenia, or low platelet count. The platelets should be reviewed under the microscope on a peripheral blood smear. Several types of congenital platelet function disorders result in platelets that are larger than normal. Other platelets are missing key components, called granules, which can be seen under the microscope. Sometimes the platelets are normal in appearance and size. The remaining work-up begins similarly to other bleeding disorders. Unlike in hemophilia (a disorder of coagulation factors), screening tests like prothrombin time (PT) and partial thromboplastin time (PTT) are normal. Diagnosing platelet function disorders requires specialty testing. The following is a list of some commonly used tests. Bleeding time: This test is not considered specific to platelet function disorders, and because of test limitations is not considered an accurate test of the clotting system.Platelet function assay: This is considered to be a good screening test for platelet disorders. This test is affected by platelet count and may not be accurate if your platelet counts are low.Platelet aggregation testing: This test looks at how well the platelets stick to one another (aggregation) in response to different stimuli. This test can also be used to measure the effectiveness of aspirin or clopidogrel (Plavix) therapy.Flow cytometry: This test uses lasers to activate surface platelets in order to find out how they changed from the process. Treatment Treatment is based on the individual platelet function disorder you have. Some platelet function disorders rarely need treatment unless you are injured or require surgery. Aspirin and NSAIDs: Avoid aspirin or non-steroidal anti-inflammatory (NSAIDs) like ibuprofen. These medications reduce the function of platelets which may worsen the bleeding risk. Hormonal contraceptives: Hormonal contraceptives can be used to keep menstrual bleeding to a minimum. Anti-fibrinolytic medications: Because it can be difficult for the body to make stable clots, particularly on the moist surfaces of the mucosa (mouth, nose, etc.), antifibrinolytic medications like Amicar or Lysteda may be used to stop bleeding. These medications are commonly used in these conditions for nosebleeds, gum bleeding, and menorrhagia. They can also be used after surgical procedures (particularly, mouth, nose, and throat) to prevent bleeding. Platelet transfusions: Even in platelet function disorders with normal platelet counts, platelet transfusions may be used for severe bleeding or if you need surgery. Factor VIIa (NovoSevenRT) infusion: This factor replacement product can be used in some patients with platelet function disorders. This is used mostly in patients who are unable to receive platelet transfusions as a treatment option. 1 Source Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Sharda A, Flaumenhaft R. The life cycle of platelet granules. F1000Res. 2018;7:236. doi. 10.12688/f1000research.13283.1. Published February, 2018. By Amber Yates, MD Amber Yates, MD, is a board-certified pediatric hematologist and a practicing physician at Baylor College of Medicine. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit