CFS & Fibromyalgia Symptoms Physical and Emotional Symptoms of Low Serotonin Serotonin deficiency is linked to pain, fatigue, depression, and more By Adrienne Dellwo Adrienne Dellwo LinkedIn Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic. Learn about our editorial process Updated on December 15, 2022 Medically reviewed by Steven Gans, MD Medically reviewed by Steven Gans, MD Steven Gans, MD, is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Expert Board Print Table of Contents View All Table of Contents What Serotonin Does Physical Symptoms Emotional Symptoms How Do I Know If My Serotonin Levels Are Low? How to Increase Levels Frequently Asked Questions Serotonin is a chemical messenger that helps with regulating mood. It sometimes acts like a hormone as well. Given all the roles it plays, it makes sense that having low serotonin can cause such a range of symptoms, both physical and emotional. Symptoms of low serotonin include: DepressionNegative thoughtsAnxietyIrritabilityLow energyFatigueMemory problemsChanges in sleep patternsChronic painChanges in appetiteBinge eatingLoss of interest in sex This article goes over what serotonin does, the range of possible low-serotonin symptoms, how low serotonin is diagnosed, and what you can do to boost your levels, if needed. demaerre / Getty Images What Serotonin Does Serotonin is a regulator of many processes in the body. When it's out of whack, these processes are no longer regular. Serotonin's dual nature as a neurotransmitter and hormone means that it's found throughout your body. Perhaps surprisingly, there's more serotonin in your gut than in your brain. The effects of low serotonin can be many, and seemingly unrelated symptoms may, in fact, be all related to it. Take fibromyalgia (FMS) and chronic fatigue syndrome (CFS or ME/CFS), for example. Both are thought to be tied to serotonin deficiency. Irritable bowel syndrome (IBS) also involves serotonin dysregulation and happens to be extremely common in those with either of these conditions. Learning to spot the signs of low serotonin can help you get a diagnosis and treatment. Physical Symptoms of Low Serotonin Some of the physical symptoms linked to low serotonin are: Chronic fatigue even though you get adequate restDisturbed sleepLoss of appetite or carb cravings (possibly from the body's attempt to make more serotonin)Hot flashes and temperature changes that are not linked to your environmentHeadachesStomach pains Certainly, some of these symptoms can crop up in anyone's life from time to time. The key here is to recognize whether you have clusters of symptoms that tend to occur together. Serotonin levels can fluctuate, leading to symptom flares and remissions (times when symptoms are gone or at low levels). Emotional Symptoms of Low Serotonin Emotional symptoms associated with low serotonin include: Social withdrawalSadness and frequent crying spellsLow self-esteem and self-confidenceChanges in personalityFeeling emotionally sensitive and taking things personallyIrritability The presence of emotional symptoms does not confirm a mental health issue. However, serotonin is involved in certain mental illnesses, such as major depressive disorder. Talk to your healthcare provider about if you have any of these symptoms of low serotonin. How Do I Know If My Serotonin Levels Are Low? Measuring neurotransmitters is not a reliable way to diagnose low serotonin. Instead, healthcare providers rely on a review of your symptoms to make a diagnosis. If you have physical and emotional symptoms that you think could be from low serotonin, it’s important to reach out to your primary care provider or a mental health provider for an evaluation. Getting Help If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at 1-800-273-8255 for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call 911 without delay. For more mental health resources, see our National Helpline Database. How Can I Raise Serotonin Levels? There are many ways to fix low serotonin. Some people find that a combination of strategies work best for raising their serotonin levels and keeping them in a range that supports their physical and mental health. Antidepressant medications like SSRIs, SNRIs, MAOIs, and tricyclics can treat low serotonin. Your provider may prescribe one to you. Know, however, that these drugs can take some time to work. In the meantime, your provider can suggest other strategies that might help boost your levels, including: Eating a nutritious diet that includes foods like nuts and seeds, animal protein, and soy, as well as probiotic rich fermented foods Exploring herbs and supplements like ashwagandha Getting plenty of fresh air and sunlight during the day Being physically active in a way that you enjoy Making quality sleep a priority Managing your stress levels Reaching out for support from family and friends and/or providers Continuing these strategies even after you start medication can also be helpful. Before trying any supplements, talk to your provider—especially if you're taking prescription medications like antidepressants. Summary Serotonin is an important brain chemical that also works like a hormone. If you don't have enough serotonin, you can have physical and emotional symptoms that can be disruptive to your daily life. Conditions like chronic fatigue syndrome (CFS) and fibromyalgia might be related to serotonin deficiency. If you think you might have low levels of serotonin, talk to your provider. There are different ways to raise your levels and keep them up so you can feel and function at your best. Frequently Asked Questions Does low serotonin cause OCD symptoms? Low serotonin has been noted in people with obsessive-compulsive disorder (OCD). However, research has not confirmed a causal connection. Is dizziness a symptom of low serotonin? Declining serotonin levels can cause dizziness. This may be because the vestibular system, which preserves a sense of balance, has many serotonin receptors—structures that allow messages from serotonin to be received. Is anger a symptom of low serotonin? Aggression (hostile action) has long been an established symptom of low serotonin, but research also indicates that anger (the feeling) may be one as well. What causes a drop in serotonin levels? Low serotonin can happen because your body does not make enough or it does not use it efficiently. There are likely several factors that cause or contribute to this. These may include genetics, stress, chronic pain, and nutritional deficiencies. Serotonin Dysregulation in FMS and ME/CFS 17 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Berger M, Gray JA, Roth BL. The Expanded Biology of Serotonin. Annu Rev Med. 2009;60:355-366. doi:10.1146/annurev.med.60.042307.110802 Becker S, Schweinhardt P. Dysfunctional Neurotransmitter Systems in Fibromyalgia, Their Role in Central Stress Circuitry and Pharmacological Actions on These Systems. Pain Res Treat. 2012;2012:741746. doi:10.1155/2012/741746 Padhy SK, Sahoo S, Mahajan S, Sinha SK. 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By Adrienne Dellwo Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit