Bronchopleural Fistula Causes and Treatment

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stethoscope next to word fistula
What is a brochopleural fistula, what are the symptoms and causes, and how are they treated?. Photo©Sohel Parvez Haque

A bronchopleural fistula is an abnormal passageway (a sinus tract) that develops between the large airways in the lungs (the bronchi) and the space between the membranes that line the lungs (the pleural cavity). When a passageway like this develops, air that is breathed into the lungs can travel through the passageway and enter the pleural space.


There are several conditions which can cause a bronchopleural fistula. Some of these include:

  • Lung cancer surgery - Pulmonary resection (removal of a lung or part of a lung) for lung cancer is by far the most common cause of a bronchopleural fistula. It is more likely to occur with a pneumonectomy (complete removal of a lung) than with procedures such as a lobectomy (removal of a lobe of the lung) or a wedge resection (removal of a wedge-shaped section of a lobe of the lung. In a 2016 study, 1.4 percent of people having a lobectomy and 14.3 percent of people having a pneumonectomy developed a bronchopleural fistula after surgery. 
  • Infection (especially some types of pneumonia which resulted in a breakdown of tissue called lung necrosis.)
  • Persistent spontaneous pneumothorax - This refers to a collapsed lung (pneumothorax) which isn't going away.
  • Chemotherapy or radiation therapy for lung cancer - Any treatment which causes damage to cells and subsequent healing in the region of the pleural border may result in the formation of a fistula.
  • Tuberculosis.

How Common Is It?

Studies looking at the incidence of bronchopleural fistulas vary, but it appears to occur in between 1.5 and 28 percent of surgeries involving removal of a lung. As noted earlier, it is more likely to occur with more extensive surgeries and is more likely to occur after a right-sided pneumonectomy, when mechanical ventilation is needed for a prolonged period of time following surgery, and when high doses of radiation are given prior to surgery.

Most often, a bronchopulmonary fistula will be found one to two weeks after lung surgery, although a fistula may occur even a month after surgery.


As noted below under diagnosis, a bronchopleural fistula is often diagnosed based on imaging findings when a persistent air leak develops. When symptoms are present, they can be easily dismissed as they are symptoms which may be expected following lung infections and surgery, such as a persistent cough, coughing up blood, or shortness of breath.


The diagnosis of a bronchopleural fistula is usually made based on radiological findings. A CT scan is often the test of choice for diagnosing the condition and may show increased air or fluid (often pus or an empyema) in the pleural space.

A bronchopleural fistula is usually suspected clinically by noting a persistent air leak. In other words, these fistulas are often discovered when a chest tube is unable to be removed following lung surgery due to a persistent air leak. There may be continuous bubbling, or instead, an air leak may be present only during inspiration or expiration. With a small air leak, bubbling may only be present during forced expiration or a cough.


Treatment may be done surgically, or endoscopically through a bronchoscopy tube (sometimes this is the only method available if the patient is unstable) and recent studies suggest that endoscopic procedures may be both safer and effective or most people.  Regardless of the procedure, drainage of the fluid in the pleural space (through a thoracentesis or maintaining a chest tube) and intravenous antibiotics are important.

  • Surgery may be used to close the fistula.
  • Bronchoscopy - In this procedure, the fistula is accessed and glues or sealants are inserted to close the passageway. These chemicals (usually silver nitrate) cause inflammation in the fistula which leads to scarring and closure, effectively gluing the abnormal passage shut.


A bronchopleural fistula is a severe complication of lung cancer surgery with mortality (death) rates varying from 10 to 27 percent depending on the study. With prompt recognition and conservative treatment, it's likely that the prognosis of bronchopleural fistulas will improve.

Also Known As: bronchopleural air leak, BPF

Examples: Sam developed a bronchopleural fistula after his pneumonectomy for lung cancer and needed to remain in the hospital longer than he had anticipated.

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