Blood Disorders What Is a Comprehensive Metabolic Panel (CMP)? What to expect when undergoing this test By Mary Kugler, RN Mary Kugler, RN, is a pediatric nurse whose specialty is caring for children with long-term or severe medical problems. Learn about our editorial process Mary Kugler, RN Medically reviewed by Medically reviewed by Jason DelCollo, DO on January 20, 2020 Jason DelCollo, DO, board-certified in family medicine. He is associate faculty at Philadelphia College of Osteopathic Medicine as well as adjunct faculty with the Crozer Family Medicine Residency Program, and is an attending physician at Glen Mills Family Medicine in Glen Mills, Pennsylvania. Learn about our Medical Review Board Jason DelCollo, DO Updated on May 12, 2020 Print Table of Contents View All Table of Contents Purpose of Test Components Before the Test During the Test Interpreting Results A comprehensive metabolic panel (CMP) is a set of 14 blood tests that give your doctor valuable information about your body's metabolism, in particular liver and kidney functioning, fluid balance, and electrolyte levels. It may be done to assess your general health or to diagnose and follow the course of certain diseases and their management. Also referred to as a metabolic panel, chemistry panel, or chem 14, this is a relatively common test that is done from a single blood draw. Rafe Swan / Getty Images Purpose of Test A CMP is typically done as part of your yearly checkup. It can also be ordered if you are ill and hospitalized. Your doctor may also order a comprehensive metabolic panel based on your risk factors for certain conditions, or to monitor them if you're already diagnosed, such as: Type 2 diabetes Kidney disease Liver disease Hypertension In addition to determining the health of your liver and kidneys, the CMP also checks the status of your blood sugar and protein levels, as well as your body's electrolytes and fluid balance. The CMP doesn't necessarily diagnose a single condition. Given the breadth of the test, it often gives your doctor a starting point to order more targeted tests to diagnose a specific condition. The test may also be used to monitor medications that could affect kidney or liver function. Those can include pain relievers (acetaminophen, naproxen, ibuprofen), statins, antibiotics, and illegal street drugs (cocaine, heroin, amphetamines). Components The 14 tests that make up a comprehensive metabolic panel are as follows. These measures are useful to review together, rather than alone, as patterns of results can be more telling—which is why they are tested at the same time. Proteins Albumin: A protein produced by the liver that helps transport vitamins and enzymes through your bloodstream. The test measures liver function. Total protein: Measures all the proteins in the blood Electrolytes Sodium: Essential to basic, normal body function, including fluid maintenance, as well as muscle and nerve function. Elevated sodium levels may increase fluid retention and blood pressure. Potassium: Helps maintain proper heart and muscle function. High or low potassium can be related to hypertension and kidney disease. Carbon dioxide: Helps maintain your body's pH (acid/base) balance Chloride: Affects fluid and pH balance Kidney Tests BUN (blood urea nitrogen): The kidneys remove this waste product from the blood. High levels are a red flag for kidney function. Creatinine: A waste product created by muscle function. Elevated levels could indicate kidney problems. Liver Tests ALP (alkaline phosphatase): A liver and bone enzyme that can indicate liver damage and bone disorders ALT (alanine aminotransferase): A liver and kidney enzyme AST (aspartate aminotransferase): A heart and liver enzyme Bilirubin: A liver waste product Other Glucose: Also referred to as your blood sugar, this is your body's main source of energy. Elevated blood sugar can be a sign of prediabetes and diabetes. Calcium: This mineral is critical for proper muscle and heart function, as well as bone formation. The basic metabolic panel (BMP) is a simpler alternative to the CMP. It includes the same CMP measurements minus the liver and protein tests. Your doctor may order this less-comprehensive test if, for example, liver function isn't a concern. The ups and downs of blood sugar. Before the Test A complete metabolic panel takes only a few minutes. It may be done at your doctor's office or lab facility. It may also be done in an ER setting or if you've been admitted to the hospital. As the test requires a minimum eight-hour fast, many patients schedule it for first thing in the morning. The blood draw will be taken from your arm, so it makes sense to wear something with sleeves that can be easily rolled up. During the Test A metabolic panel is based on a single blood draw. The procedure followed is the same as with any other venipuncture, and your sample will be collected by a nurse or phlebotomist. The draw site will be cleaned with alcohol. A tourniquet will be placed above the area where the needle will be inserted. You may also be asked to squeeze something to draw more blood into your vein. A small needle will be inserted so blood can be collected. Once the vial is full, the needle will be taken out, pressure will be put on the site, and a bandage will be placed. You will be allowed to leave right after the test. Your sample will then be sent to a lab for analysis. Risks A comprehensive metabolic panel is generally safe. The only risks stem from the blood draw itself, and these tend to resolve quickly. Bruising/bleeding at the injection site Soreness from multiple sticks to find a vein Infection Anxiety and/or dizziness from having blood taken How to Make Blood Draws Easier Interpreting Results Your doctor should get results back quickly, in a day or two at the most. As details of the various tests involved reveal, the metabolic panel gives doctors a comprehensive look at overall metabolic health, particularly the liver and kidneys and their different processes. Your doctor will typically look for patterns in the variety of results, rather than at one specific result. Mildly higher or lower results in one area may not be medically significant. Test Normal Range Albumin 3.4 to 5.4 g/dL (34 to 54 g/L) ALP 20 to 130 U/L ALT 4 to 36 U/L AST 8 to 33 U/L Bilirubin 0.1 to 1.2 mg/dL (2 to 21 µmol/L) BUN 6 to 20 mg/dL (2.14 to 7.14 mmol/L) Calcium 8.5 to 10.2 mg/dL (2.13 to 2.55 mmol/L) Carbon dioxide 23 to 29 mEq/L (23 to 29 mmol/L) Chloride 96 to 106 mEq/L (96 to 106 mmol/L) Creatinine 0.6 to 1.3 mg/dL (53 to 114.9 µmol/L) Glucose 70 to 100 mg/dL (3.9 to 5.6 mmol/L) Potassium 3.7 to 5.2 mEq/L (3.70 to 5.20 mmol/L) Sodium 135 to 145 mEq/L (135 to 145 mmol/L) Total protein 6.0 to 8.3 g/dL (60 to 83 g/L) In the case of someone hospitalized, multiple CMPs may be ordered on different days to monitor progress. Follow-Up While abnormal tests could indicate serious medical conditions like diabetes and kidney/liver problems, more condition-specific tests will follow to achieve an accurate diagnosis. If your doctor wants to perform an even deeper metabolic workup, the following additional blood tests can be ordered (if they haven't been already): Complete blood cell count (CBC) Thyroid tests Creatine phosphokinase (CPK) Vitamin B12 level Ammonia (ammonium ion test) Hemoglobin A1C A Word From Verywell Be sure to have a thorough discussion with your doctor about any abnormal results and what further steps you may have to take to address concerns. The best way to reduce any test anxiety is by asking questions and having a full understanding of what a CMP means for your health. Complete Blood Count (CBC) Analyzer: Decode Your Results Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. American Association for Clinical Chemistry. Comprehensive metabolic panel. American College of Gastroenterology. Medications and the liver. Updated December 2012. National Kidney Foundation. Which drugs are harmful to your kidneys? National Institutes for Health. MedlinePlus. Albumin blood test. National Institutes for Health. MedlinePlus. Potassium blood test. Additional Reading National Institutes for Health. MedlinePlus. Medical encyclopedia: Comprehensive metabolic panel. Updated January 26, 2019. National Institutes for Health. MedlinePlus. Medical tests: Comprehensive metabolic panel.