5 Things That Could Adversely Affect Your Cholesterol Levels

High cholesterol is a condition that often sneaks up on us. There are usually no symptoms associated with it, yet it could contribute to cardiovascular disease if you ignore it. High cholesterol can develop either from something wrong with the way cholesterol is being made in your body, certain things you are doing in your everyday life, or a combination of both.

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The liver is the main organ of the body that makes cholesterol. Your body needs cholesterol to perform many biological functions, such as making hormones (like estrogen or testosterone) and providing structure to cells. In fact, your liver makes most of the cholesterol your body needs on a daily basis. But having too much of certain types of cholesterol is not healthy.

Cholesterol levels can also be affected by outside factors—including your diet and certain lifestyle factors.

Although there are different types of cholesterol, there are two main types of cholesterol that are commonly considered when assessing your risk for cardiovascular disease:

Studies have shown that high LDL cholesterol and low HDL cholesterol could raise your risk of developing cardiovascular disease if it’s not treated.

There are many factors that can cause your cholesterol levels to go out of range. The good news is that some of these factors involve lifestyle habits that are within your control.

There are also some contributing factors you may have no control over. In these cases, there are cholesterol-lowering medications your healthcare provider can prescribe that can bring your cholesterol levels back within a healthy range.

The following factors could adversely affect your cholesterol levels.

You Aren’t Eating Healthy

A diet that is high in saturated fat, trans fat, and/or refined sugars can adversely affect your cholesterol levels by causing your LDL cholesterol levels to increase and your HDL cholesterol levels to decrease.

The American Heart Association recommends that only about 5% to 6% of your daily calories should come from saturated fat. Refined sugars and trans fats—which are introduced into various foods, including cookies, cakes, and chips—should be limited or avoided entirely.

Whenever in doubt, always check the nutrition label on food packages for the amount of each of these items. If the food you are eating is not packaged, you can usually find out the type and amount of fat and sugar that is present in most foods by checking online.

You Don’t Have Certain Medical Conditions Under Control

Some medical conditions may also adversely affect your LDL, HDL, and total cholesterol levels, especially if you don’t get adequate treatment.

These conditions include:

  • Diabetes, prediabetes, insulin resistance, or metabolic syndrome
  • Obesity
  • Hypothyroidism
  • Kidney disease

In most cases, addressing these underlying medical conditions will bring your cholesterol levels back within healthy levels.

Your Medications Are Increasing Your Cholesterol

Some of the medications that you are taking for other medical conditions may also cause a slight elevation in your LDL cholesterol levels. These include medications like thiazide diuretics (used to remove excess fluid from the body), estrogen and progesterone (used in hormone replacement therapy), atypical antipsychotics, beta-blockers, and certain HIV medicines. In some cases, this elevation is only temporary.

Your healthcare provider will monitor your lipid profile if you taking a medication that could adversely affect your cholesterol level.

You’ve Developed Some Unhealthy Habits

There are other things that you might be doing in your everyday life that could be causing your cholesterol levels to be too high. Certain lifestyle factors that could be sabotaging your cholesterol levels include:

  • Not getting enough exercise
  • Not getting enough sleep
  • Smoking cigarettes
  • Living or working in a high-stress environment

These lifestyle habits could cause your LDL cholesterol levels to increase to some degree and in some cases also lower HDL cholesterol. Making positive changes in your lifestyle by eliminating these unhealthy habits could improve your lipid profile and your heart health.

It’s In Your Genes

Increased LDL cholesterol, decreased HDL cholesterol, or a combination of both may also be inherited from one or both of your parents. Early-onset cholesterol diseases have been linked to mutations in several genes. The most common cause is a mutation in the gene that encodes the LDL receptor (LDLR). Other culprits are mutations that affect the genes for apolipoprotein B (APOB), proprotein convertase subtilisin/kexin type 9 (PCSK9), and LDL receptor adaptor protein 1 (LDLRAP1).

If you have a family history of high cholesterol or cardiovascular disease, you should disclose this to your healthcare provider. They can periodically monitor you to detect any changes in your cholesterol levels so you can start treatment early and prevent the effects of high cholesterol.

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11 Sources
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  1. Harvard Health Publishing. How it’s made: cholesterol production in your body.

  2. Centers for Disease Control and Prevention. LDL and HDL cholesterol: "bad" and "good" cholesterol.

  3. Van Horn L, Carson JAS, Appel LJ, et al. Recommended dietary pattern to achieve adherence to the American Heart Association/American College of Cardiology (AHA/ACC) guidelines: a scientific statement from the American Heart Association. Circulation. 2016;134(22):e505–e529. doi:10.1161/CIR.0000000000000462

  4. Bjornstad P, Eckel RH. Pathogenesis of lipid disorders in insulin resistance: a brief review. Curr Diab Rep. 2018;18(12):127. doi:10.1007/s11892-018-1101-6

  5. Mc Auley MT. Effects of obesity on cholesterol metabolism and its implications for healthy ageing. Nutr Res Rev. 2020;33(1):121-133. doi:10.1017/S0954422419000258

  6. Duntas LH, Brenta G. A renewed focus on the association between thyroid hormones and lipid metabolism. Front Endocrinol. 2018;9:511. doi:10.3389/fendo.2018.00511

  7. Reiss AB, Voloshyna I, De Leon J, Miyawaki N, Mattana J. Cholesterol metabolism in CKD. Am J Kidney Dis. 2015;66(6):1071-1082. doi:10.1053/j.ajkd.2015.06.028

  8. Du S, Su Y, Zhang D, Wu J, Zheng H, Wang X. Joint effects of self-reported sleep and modifiable physical activity on risk of dyslipidaemia in women aged 45–55 years: a cross-sectional study. BMJ Open. 2022;12(1):e049351. doi:10.1136/bmjopen-2021-049351

  9. Jain RB, Ducatman A. Associations between smoking and lipid/lipoprotein concentrations among US adults aged ≥20 years. J Circ Biomark. 2018;7:184945441877931. doi:10.1177/1849454418779310

  10. Yao BC, Meng LB, Hao ML, Zhang YM, Gong T, Guo ZG. Chronic stress: a critical risk factor for atherosclerosis. J Int Med Res. 2019;47(4):1429-1440. doi:10.1177/0300060519826820

  11. Bouhairie VE, Goldberg AC. Familial hypercholesterolemia. Cardiol Clin. 2015;33(2):169-179. doi:10.1016/j.ccl.2015.01.001