What Is Chondrocalcinosis?

In This Article
Table of Contents

Chondrocalcinosis, also known as calcium pyrophosphate deposition (CPPD) disease, is a condition in which calcium pyrophosphate crystals build up in the joints. The deposits cause irritation that can cause inflammation and cartilage damage. The symptoms can be similar to gout and other types of arthritis. According to the Arthritis Foundation, almost half of the people aged 85 or above have chondrocalcinosis.

An X-ray showing osteoarthritis of the knee.
SMC Images/Getty Images

CPPD Symptoms

Not everyone who develops calcium crystals in their joints will show symptoms. When symptoms occur, they usually affect the knees but can also involve the shoulders, wrists, elbows, ankles, hands, or other joints.

You may experience episodes that arrive suddenly and last for days or weeks. CPPD is sometimes referred to as pseudogout because symptoms can sometimes be similar to gout. Also, joint inflammation can result in symptoms associated with osteoarthritis or rheumatoid arthritis. These symptoms include:

  • Joint pain and swelling, especially shoulders, elbows, wrists, knuckles, knees, and ankles
  • Low-grade inflammation
  • Warm joints
  • Morning stiffness, fever, and fatigue
  • Decreased joint function


Most of the time, there is no known cause for CPPD. Developing CPPD is more likely as you age, although it can occur in young people, too. CPPD does tend to run in families, so genetics might to play a role. Other possible causes include:


To diagnose CPPD, your doctor may use a needle to take fluid from your painful joint to look for whether you have calcium pyrophosphate crystals. They may also use imaging techniques like X-rays, CT, or MRI to detect the presence of crystal deposits. Blood tests may be performed to rule out any other condition.


While treatment isn’t available to dissolve the crystal deposits, your doctor can suggest ways to relieve symptoms. For inflammation, swelling, and pain, your doctor may recommend nonsteroidal anti-inflammatory drugs (NSAIDs) like Indocin (indomethacin) and Naprosyn (naproxen).

When a joint affected by CPPD becomes extremely painful and swollen, your doctor may drain some of the built-up fluid by inserting a needle into the area. This might also remove some of the crystals from the joint. After that, a corticosteroid and a numbing medication can be injected into the joint to decrease inflammation and pain. Your doctor may also prescribe low doses of a prescription drug called colchicine that's used to treat gout.

For severe attacks or chronic inflammation, your doctor may prescribe medication, such as Plaquenil (hydroxychloroquine), Trexall (methotrexate), or Kineret (anakinra). Surgery to replace damaged joints may also be an option in severe cases.

When caring for CPPD at home, you can try applying ice packs for short periods to help reduce pain and inflammation in the joints. Maintaining a healthy weight can also minimize stress on the joints and reduce inflammation.

A Word From Verywell

If you’re experiencing joint pain or swelling, contact your doctor. Through tests and imaging, they can help determine if your pain is caused by CPPD. With medications and at-home care, you can usually manage symptoms and maintain joint function.

Was this page helpful?
Article Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. American College of Rheumatology. Calcium Pyrophosphate Deposition (CPPD). Updated March 2017.

  2. Arthritis Foundation. Calcium Pyrophosphate Deposition