Frontotemporal Dementia Symptoms, Types, Treatments

FTD Is Sometimes Called Pick's Disease

Frontotemporal Dementia (Pick's Disease)
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Frontotemporal dementia (FTD) is a type of dementia that has often been called Pick’s disease. It encompasses a group of disorders that affect behavior, emotions, communication and cognition. Other names used for FTD include:

  • frontotemporal degeneration
  • frontal temporal dementia
  • Pick's complex
  • frontotemporal lobar degeneration
  • frontal dementia

In FTD, the frontal and temporal lobes of the brain are affected and atrophy (shrink) in size. FTD typically strikes relatively young persons (50s to 60s), but it has also been identified in people as young as 21 and as old as the late 80s. About 60% of cases of FTD are people between the ages of 45 and 64.

Arnold Pick first identified the abnormal tau protein collections in the brain (called Pick’s bodies) in 1892. Pick’s bodies are present in some types of FTD and can only be seen under a microscope during an autopsy.

Types of FTD

Four disorders that fall into the FTD category include:

Symptoms of FTD

People with FTD often demonstrate socially inappropriate behavior, such as tactless comments, lack of insight or empathy, distractibility, increased interest in sex, or significant changes in food preferences. Others display poor hygiene, repetitive comments or behaviors, low energy and poor motivation. They may also have a flat or blunted affect, meaning that their faces display little or no expression of emotion, including sadness, joy, or anger.

FTD often affects the ability to communicate in both expressive speech (the ability to use words to express yourself) and receptive speech (the ability to understand speech). Individuals may have trouble finding the right word to say, speak very hesitantly and slowly, have a hard time reading and writing accurately, and not be able to form sentences in a way that makes sense.

Movement Changes

FTD often affects the ability to control movement and other motor actions. Those with FTD may fall frequently or have unwanted arm and leg movements or shakiness.

Interestingly, a person's memory and understanding of the space around them often remain relatively intact, especially in the earlier stages.

How Do FTD and Alzheimer's Differ?

In Alzheimer’s, the typical initial symptoms are short-term memory impairment and difficulty learning something new. In FTD, the memory usually remains intact initially; early symptoms include difficulty with appropriate social interactions and emotions, as well as some language challenges.

FTD and Alzheimer’s also differ in how the brain is physically affected. FTD mainly affects the brain's frontal and temporal lobes; while Alzheimer’s tends to impact most areas of the brain.

FTD also targets younger individuals. The average age of onset for FTD is about 60 years old. While some people have early onset Alzheimer’s, the majority of patients are over 65 and many of those are well into their 70's or 80's.

What Causes FTD?

The cause of FTD is not known. While the majority of cases of FTD appear to develop by chance, genetics does play a role in some cases. Approximately 10% of cases can be traced back to a change in a single gene. This gene mutation is directly inherited, meaning that if your mother or father has that specific gene for FTD, you have a 50% chance of developing FTD.

An additional 20% to 40% of people diagnosed with FTD have a familial connection where more than one relative over two or more generations has been diagnosed with FTD.


Similar to diagnosing Alzheimer’s disease, there is no single test that can diagnose FTD. Patients typically undergo some imaging testing such as an MRI or a PET scan; cognitive testing to measure memory and language abilities; physical movement testing; possibly a spinal tap; and some blood tests. Diagnosis is made by gathering all of the results from these tests, ruling out other causes such as vitamin B12 deficiency or infections, and comparing your symptoms to other cases of FTD. It is important that a neurologist familiar with FTD and other types of dementia be involved in this evaluation since certain aspects of FTD mimic other disorders.


There is no medication that targets this type of dementia, so the treatment goal is to control symptoms as much as possible. Physicians may prescribe medications that are often used for the movement problems in Parkinson's disease, including Carbidopa/levodopa (Sinemet). Sometimes the behaviors of FTD are addressed with antipsychotic medications if non-drug approaches are ineffective.

Antidepressant medications, specifically selective serotonin reuptake inhibitors (SSRIs), have shown some benefit in treating some of the obsessive or compulsive behaviors of FTD. Some physicians will also prescribe medications usually given to Alzheimer’s patients, including cholinesterase inhibitors. Research, however, has not clearly shown these medications to be effective for FTD yet.

Occupational and physical therapy can also benefit patients by helping maintain or slow the deterioration of the motor and movement abilities, while speech therapy can sometimes assist with communication deficits.

Prevalence of Frontotemporal Dementia

About 10% to 20% of all dementias are FTD, which translates to an estimated 50,000 to 60,000 Americans. FTD is one of the more common types of dementia in adults younger than age 65, and it is more common in men than women.


The prognosis of FTD is poor. Life expectancy ranges anywhere from from two to 20 years after diagnosis, depending on the speed of progression and the presence of other diseases. FTD does not cause death, but it makes fighting other illnesses and infections more difficult.

A Word from Verywell

Frontotemporal dementia is one kind of dementia that's generally not nearly as well-known as Alzheimer's disease. Gaining an understanding of how it might affect you or your loved one can help prepare you for what to expect and how best to cope with its effects.

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Article Sources

  • National Center for Biotechnology Information, U.S. National Library of Medicine. Pub Med Health. Pick’s Disease.
  • The Association for Frontotemporal Degeneration. Diagnosis.
  • The Association for Frontotemporal Degeneration. Genetics.
  • The Association for Frontotemporal Degeneration. Frontotemporal Degeneration.
  • U.S. National Institutes of Health. National Institute on Aging. Types of Frontotemporal Disorders.
  • University of California, San Francisco. Forms of Frontotemporal Dementia. 
  • University of California, San Francisco. Hereditary FTD.