Asthma How Histamine Impacts Your Asthma By Pat Bass, MD Pat Bass, MD LinkedIn Twitter Dr. Bass is a board-certified internist, pediatrician, and a Fellow of the American Academy of Pediatrics and the American College of Physicians. Learn about our editorial process Updated on January 21, 2022 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Corinne Savides Happel, MD Medically reviewed by Corinne Savides Happel, MD LinkedIn Corinne Savides Happel, MD, is a board-certified allergist and immunologist with a focus on allergic skin disorders, asthma, and other immune disorders. Learn about our Medical Expert Board Print Histamine is a natural chemical produced by the body. It has many functions, including acting as a relay messenger between different parts of the immune system. Overactivity of histamine is associated with allergies. Science Photo Library / Getty Images How Histamine Works Histamine mediates your body's natural defense mechanisms to protect you from harmful substances. Asthma and allergy symptoms can develop when your body over-reacts to something that is not particularly harmful but that has caused your immune system to react. Immune cells called mast cells and white blood cells known as basophils release histamine when you are exposed to allergens. When histamine is released, the allergic response begins. This reaction can affect different areas of your body, causing a range of symptoms: Your eyes may become itchy and wateryYour throat may be sore and scratchyWheezing, chest tightness, shortness of breath, or a cough If you have asthma, histamine may promote bronchoconstriction—tightening of the muscles surrounding the airways in your lungs—and production of mucus. What Happens to the Body During an Asthma Attack? Medications That Block Histamine Antihistamine drugs are used in the treatment of the allergic symptoms caused by the release of histamine. Some popular anti-histamine medications include Zyrtec (cetirizine), Allegra (fexofenadine), Claritin (loratadine), and Benadryl (diphenhydramine). Leukotriene modifying drugs, such as Singulair (montelukast), may also help by reducing the allergic response. The FDA has approved this type of drug for treating refractory allergic rhinitis and asthma. Refractory conditions are those that do not improve with standard therapy—this treatment is not recommended for use as a first-line treatment for allergic rhinitis or asthma. A black box warning was recently added due to severe neuropsychiatric side effects in a subset of patients using Singulair, and if you have a history of mental illness, your doctor might recommend that you avoid this treatment option. It should also be noted that while histamine can lead to bronchoconstriction, antihistamines are not a first-line agent to treat an asthma attack. Rescue inhalers like albuterol are typically prescribed for patients to carry and use when acute asthma symptoms begin. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 4 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Panula P. Histamine, histamine H3 receptor, and alcohol use disorder. Br J Pharmacol. 2020;177(3):634-641. DOI:10.1111/bph.14634 Yamauchi K, Ogasawara M. The role of histamine in the pathophysiology of asthma and the clinical efficacy of antihistamines in asthma therapy. Int J Mol Sci. 2019;20(7) doi:10.3390/ijms20071733 FDA. Singulair (Montelukast) and all montelukast generics: strengthened boxed warning - due to restricting use for allergic rhinitis. Published online September 9, 2020. FDA. FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis. Published online March 13, 2020.