Surgery Necrosis Causes and Symptoms in the Human Body How necrotic tissue develops and how it's treated By Jennifer Whitlock, RN, MSN, FN Jennifer Whitlock, RN, MSN, FN LinkedIn Jennifer Whitlock, RN, MSN, FNP-C, is a board-certified family nurse practitioner. She has experience in primary care and hospital medicine. Learn about our editorial process Updated on November 30, 2022 Medically reviewed by Cara Beth Lee, MD Medically reviewed by Cara Beth Lee, MD LinkedIn Cara Beth Lee, MD, is a board-certified Orthopedic Surgeon with over 20 years of practice experience and subspecialty expertise in hip preservation surgery, focusing on patients with pre-arthritic hip disorders. Learn about our Medical Expert Board Print Table of Contents View All Table of Contents Types of Necrosis Causes of Necrosis Risk Factors Symptoms Treatment Frequently Asked Questions Necrosis is the death of tissues of the body. It happens when tissue isn't getting enough blood due to injury, infection, or chemical exposure. Resulting damage cannot be reversed. The term gangrene refers to a large area of necrosis. The sole treatment for necrosis is the removal of the dead tissue. This article discusses the types of necrosis as well as the causes and risk factors. It also covers symptoms of necrotic tissue and how it's treated. Verywell / Cindy Chung Types of Necrosis There are several types of necrosis, as it can affect many areas of the body, including bone, skin, organs and other tissues. Each type has distinct features. The type of necrosis that develops depends on which tissues are necrotic and what event (such as an injury or infection) triggered it. The types include: Coagulative Necrosis Coagulative necrosis occurs when there is a lack of blood flow and oxygen to the affected tissues. One way this can happen is when an artery becomes blocked due to a blood clot. Coagulative necrosis can affect any organ in the body except for the brain. The necrotic tissue becomes firm and pale in comparison to surrounding tissues. Liquefactive Necrosis Liquefactive necrosis happens as a result of a bacterial, viral, fungal, or parasitic infection. It can also occur in the brain due to an ischemic injury, such as a stroke that causes the death of brain tissue. This type of necrosis is typically seen in the brain, the lungs, or the tissues surrounding a site of infection. Liquefactive necrotic tissue softens until it turns into a pus-filled abscess. Caseous Necrosis Caseous necrosis is another type of necrosis that typically happens as a result of a bacterial or fungal infection. The most common cause of caseous necrosis is tuberculosis—a bacterial disease that leads to caseous necrosis in the lungs. Caseous necrotic tissue has a cheese-like appearance. The necrotic tissue becomes yellowish-white and soft with a well-defined border around the affected area. Fat Necrosis Fat necrosis is necrosis that occurs in parts of the body that contain a lot of fatty tissue, such as the pancreas and breast tissues. Fat necrosis is often triggered by an event that damages the affected tissue area, such as injury, surgery, or radiation therapy. Fat necrotic tissue is speckled with small, white chalky deposits. These white spots are formed by calcium and fatty acids that are deposited into the necrotic tissue. Fibrinoid Necrosis Fibrinoid necrosis is necrosis that occurs within blood vessels. It is triggered by immune reactions that damage blood vessels. Fibrinoid necrotic tissue is usually not visible to the naked eye. When viewed under a microscope, inflammation and the buildup of a substance called fibrinoid can be seen in blood vessel walls. Causes of Necrosis Necrotic tissue forms when not enough blood—and the oxygen that blood carries—reaches the affected tissues. Blood clots and blood vessel damage are just two of the many causes that can trigger necrosis. Injuries, infections, chronic diseases, and toxins that block blood flow to an area can cause necrotic tissue to form in that area. Injury Traumatic injuries can damage blood vessels and cut off blood flow to the surrounding bones and tissue areas. Anything from a car accident to falling from a ladder can result in a traumatic injury that triggers necrosis. Frostbite, in which tissues are severely damaged by cold, is a common cause of necrosis. If frostbite is not treated quickly, the frostbitten area turns black and dies (gangrene). These necrotic tissues cannot be healed and are typically removed via surgical amputation. Use These Pictures to Identify Frostbite Other injuries that can lead to necrosis include: Electrical burn Bone fracture Traumatic brain injury Chemical burn Radiation exposure Infarction Infarction is tissue death that occurs when not enough blood reaches the affected area. Necrosis due to infarction is often the result of a blood clot, such as a deep vein thrombosis (DVT) that forms in a blood vessel and blocks blood flow to the surrounding area. If blood flow is not restored quickly, the area starves for oxygen and eventually dies. DVT usually happens in the legs (but can happen anywhere in the body). It can result in the loss of tissue below the site of the blockage if the blood vessel is completely blocked. Infection A wide variety of bacterial, viral, fungal, and parasitic infections can trigger necrosis. Even a minor cut or scrape that gets infected can lead to necrosis. Some types of infection more commonly cause necrosis than others. In particular, the bacteria called group A Streptococcus is thought to be the most common necrotizing infection. Necrotic tissue due to infection is most often seen on the extremities, particularly the hands and feet, as well as the genitals. Other viruses that can induce necrosis include: Human immunodeficiency virus (HIV) Herpes simplex virus type-1 (HSV-1) West Nile virus Vaccinia virus (related to smallpox) Disease Certain autoimmune diseases are known to cause necrosis, the most common of which is systemic lupus erythematosus (SLE). It's thought that people who treat their SLE with corticosteroids are most at risk, as long-term use of corticosteroids weakens bones. A number of other diseases can trigger necrosis by damaging blood vessels and blocking blood flow to bones and tissues. They include: Alcoholism Sickle cell disease Decompression disease (also called diver's disease) Chronic kidney failure Cushing's disease, in which the body makes too much of the hormone cortisol Gaucher disease, a genetic disorder that causes the buildup of fat cells in certain organs Toxins Chemical agents, such as poison, venom, and certain recreational drugs are known to trigger necrosis. Exposure to arsenic, a metal found in rat poison and contaminated groundwater, can trigger necrosis in the kidneys. Cocaine that is laced with a white chemical called levamisole is linked to kidney necrosis as well. Venom injected into the skin from a brown recluse spider bite can cause necrosis unless treated quickly. Bites and stings from numerous other creatures cause necrosis, including spiders, snakes, scorpions, and jellyfish. Risk Factors With increased age comes increased vulnerability to problems that can trigger necrosis, such as injuries and vascular disease. This makes your age one of the biggest risk factors for necrosis. Abusing alcohol also puts you at a greater risk of developing necrotic tissue. Alcohol is cytotoxic, meaning that it is toxic to your cells. Abusing heavy amounts of alcohol over time can kill liver cells and trigger necrosis in your liver. Having an open wound, such as an abscess or surgical incision heightens your risk of infection and therefore necrosis. Traumatic injuries and insect bites are necrosis risk factors as well. Long-term use of corticosteroids such as prednisolone are associated with a higher risk of necrosis. Necrosis is a common complication of the autoimmune disease lupus. People who treat their lupus symptoms with corticosteroids are at an especially greater risk. Other conditions that increase the risk of necrosis include: Diabetes mellitus Vascular disease Chronic renal (kidney) failure HIV Symptoms Symptoms of necrosis vary depending on where in your body the necrotic tissue has developed. For example, symptoms of necrosis in your kidneys include: Back or flank pain Bloody, cloudy, or dark urine Painful or frequent urination Urinating large amounts or often at night When necrosis stems from a wound, symptoms can include: Pain that seems more severe than it should Fever (greater than 100.4°F) or chills Rapid heartbeat (more than 100 beats per minute) Numbness or pain extending past the wound Rapidly spreading redness from the wound Pain and warmth near the wound Skin blisters A crackling sensation under the skin (crepitus) Grayish, smelly liquid draining from the wound Difficulty thinking clearly Excessive sweating Treatment A complete blockage of blood flow is typically painful, and usually painful enough to make someone seek medical help immediately. Treatment may include surgery to restore blood flow or to remove the damaged tissues, antibiotics to prevent or treat infection, or treating the burn or other issues that caused the initial damage. In many cases, necrosis treatment starts by identifying and addressing the cause of cell death. Restoring blood flow to the affected areas is the most important priority in order to prevent further damage. Once the blood supply has been restored, which may require surgery, any dead tissue can be removed. What Is Avascular Necrosis? Frequently Asked Questions What is coagulative necrosis? Coagulative necrosis refers to a specific appearance that necrosis can have. It is defined by dead cells that sustain their shape for several days after the cells have died, and is the usual appearance of most necrosis.The other appearance pattern of necrosis is called liquefactive necrosis (colliquative necrosis). It refers to dead tissues that decompose into a viscous liquid, sometimes appearing as a creamy yellow due to pus forming. What is the difference between necrosis and apoptosis? Apoptosis is the process in which cells self-destruct. It is the body's natural and highly regulated way of getting rid of unneeded cells. While apoptosis occurs "on purpose," necrosis is uncontrolled cell death that occurs "accidentally" due to an injury or disease. Apoptosis maintains balance in the body. Necrosis causes damage. Can you take care of necrosis on your own? There are no self-treatments for necrosis, and you should not attempt to treat it at home. If you notice signs of necrosis, you should seen a healthcare provider immediately. Treatment for necrosis needs to be aggressive, and your healthcare provider will need to begin treatment quickly for it to be effective. 17 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Adigun R, Basit H, Murray J. Necrosis, cell (liquefactive, coagulative, caseous, fat, fibrinoid, and gangrenous). StatPearls. Kumar V. Cell Injury, Cell Death, and Adaptations. In: Robbins & Cotran Pathologic Basis of Disease, 2021. Chung A, Frye J, Zbesko J. Liquefaction of the brain following stroke shares a similar molecular and morphological profile with atherosclerosis and mediates secondary neurodegeneration in an osteopontin dependent mechanism. eNeuro. 2018 Nov;5(5):76-78. doi:10.1523/ENEURO.0076-18.2018 Regli IB, Strapazzon G, Falla M, Oberhammer R, Brugger H. Long-term sequelae of frostbite—a scoping review. Int J Environ Res Public Health. 2021 Sep;18(18):9655. doi:10.3390/ijerph18189655 Centers for Disease Control and Prevention. Necrotizing fasciitis: All you need to know. Hakkarainen T, Kopari N, Pham T, Evans H. Necrotizing soft tissue infections: Review and current concepts in treatments, systems of care, and outcomes. Curr Probl Surg. 2014 Aug;51(8):344-362. doi:10.1067/j.cpsurg.2014.06.001 Vanlangenakker N, Berghe TV, Vandenabeele P. Many stimuli pull the necrotic trigger, an overview. Cell Death Differ. 2012 Jan;19(1):75-86. doi:10.1038/cdd.2011.164 Dogan I, Kalyoncu U, Kilic L, et al. Avascular necrosis less frequently found in systemic lupus erythematosus patients with the use of alternate day corticosteroid. Turk J Med Sci. 2020 Feb;50(1):219-224. doi:10.3906/sag-1908-182 Narayan A, Khanchandani P, Borkar R, et al. Avascular necrosis of femoral head: A metabolomic, biophysical, biochemical, electron microscopic and histopathological characterization. Sci Rep. 2017 Sep;7(1):10721. doi:10.1038/s41598-017-10817-w Agency for Toxic Substances and Disease Registry. Arsenic toxicity: What are the physiologic effects of arsenic exposure?. Goldstein E. Emerging and underrecognized complications of illicit drug use. Clin Infect Dis. 2015 Dec;61(12):1840-1849. doi:10.1093/cid/civ689 Gutiérrez JM, Chippaux JP, Isbister G. PLOS Neglected Tropical Diseases broadens its coverage of envenomings caused by animal bites and stings. PLoS Negl Trop Dis. 2021 Jun;15(6):e0009481. doi:10.1371/journal.pntd.0009481 Bergman J, Nordström A, Nordström P. Epidemiology of osteonecrosis among older adults in Sweden. Osteoporos Int. 2019 Jan;30(5):965-973. doi:10.1007/s00198-018-04826-2 Wang S, Pacher P, De Lisle R, Huang H, Ding WX. A mechanistic review of cell death in alcohol-induced liver injury. Alcohol Clin Exp Res. 2016 Jun;40(6):1215-1223. doi:10.1111/acer.13078 Kalaivani V, Hiremath B, Indumathi VA. Necrotising soft tissue infection—risk factors for mortality. J Clin Diagn Res. 2013 Aug;7(8):1662-1665. doi:10.7860/JCDR/2013/5535.3240 Adigun R, Basit H, Murray J. Cell liquefactive necrosis. StatPearls. Negroni A, Cucchiara S, Stronati L. Apoptosis, necrosis, and necroptosis in the gut and intestinal homeostasis. Mediators of Inflammation. 2015 Sep;2015(1):1-10. doi:10.1155/2015/250762 By Jennifer Whitlock, RN, MSN, FN Jennifer Whitlock, RN, MSN, FNP-C, is a board-certified family nurse practitioner. She has experience in primary care and hospital medicine. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit