Before You Take Osteo Bi-Flex for Osteoarthritis

What to know about the ingredients in this supplement

Osteo Bi-Flex is a dietary supplement that helps maintain joint health. It's often recommended as an over-the-counter treatment for people with knee osteoarthritis and is one of the best-known supplements in this category. 

As with any supplement, you should speak with your healthcare provider before taking Osteo Bi-Flex. Your medical history may indicate that it's not right for you, and it may interact with other medications.

It's also good to know what's inside this supplement and what scientific research says about the effectiveness of its ingredients. Because Osteo Bi-Flex is a supplement, it is not approved by the Food and Drug Administration. However, the components of the drug have been studied.

Man with knee joint pain
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Osteo Bi-Flex offers a variety of formulations that contain multiple ingredients; each is a little different. However, there are a few compounds that the brand promotes as the key ingredients. Among these are "Joint Shield," UC-II collagen, glucosamine, chondroitin sulfate, and methylsulfonylmethane (MSM).

Joint Shield

Osteo Bi-Flex promotes "Joint Shield" as its main ingredient, a proprietary blend of compounds that includes 5-Loxin Advanced—Boswellia serrata extract enriched with a compound known as 3-O-acetyl-11-keto-beta-boswellic acid (AKBA).

5-Loxin is reported to be beneficial for treating osteoarthritis of the knee. In one study, it reduced pain and improved physical function in osteoarthritis patients by controlling inflammation. Though researchers say it is safe, they err on the side of caution, saying that it may improve joint health.

"Joint Shield" is found in most Osteo Bi-Flex products, though they differ slightly in the secondary ingredients. Each of these also has been reported to have some positive effects on osteoarthritis symptoms to varying degrees.


Along with chondroitin, glucosamine has long been recommended as a treatment for osteoarthritis. Its actual effectiveness is under debate and can vary from one supplement manufacturer to another.

Glucosamine is a natural compound found in human cartilage that is responsible for fluid surrounding the joints.In supplements glucosamine is either lab-generated or derived from shellfish shells. For people who have shellfish allergies, glucosamine could be problematic. It's important to read labels carefully if this is a concern for you.


Another natural compound found in the cartilage, chondroitin, helps retain water in joints. In supplements, the most common source of chondroitin is animal cartilage. 

Research into the effectiveness of glucosamine and chondroitin varies greatly. Studies and trials from supplement manufacturers show positive results in its effectiveness in osteoarthritis relief. However, trials by independent organizations have found little to no benefit.

UC-II Collagen

This is undenatured type II collagen that has been known to support joint health. It is included in several Osteo Bi-Flex products. In supplements, it is most often derived from chicken sternum cartilage. UC-II collagen has shown positive results in independent studies of osteoarthritis treatment.

A study tested the effects of UC-II collagen in patients with moderate-to-severe osteoarthritis of the knee and found that patients who took UC-II collagen reported a significant improvement in physical function, stiffness, and pain compared with patients who were given placebo or a combination of glucosamine hydrochloride and chondroitin sulfate.


Methylsulfonylmethane (MSM) is often sold alone as a dietary supplement for different health conditions, including osteoarthritis. Some Osteo Bi-Flex products contain it and typically say "with MSM" on the package.

MSM is a compound that contains sulfur, which is required by the body's connective tissues. It is thought to fight inflammation, though one study found the benefits to be minimal. It also notes that the clinical significance of MSM and osteoarthritis is unknown.

Supplements that are composed of only MSM have been known to have side effects, including upset stomach and diarrhea. Also, it should not be taken with blood thinners. Discuss this with your healthcare provider as the amount of MSM found in a particular Osteo Bi-Flex product might not be right for you.

Warnings and Precautions 

Just because a dietary supplement is old over the counter does not necessary mean it's safe for you. Talk to your healthcare provider before taking Osteo Bi-Flex. There may be an ingredient in one of the various formulas of the product that they may caution you against depending on your medical history. Consider these precautions:

  • Allergies: Shellfish allergies are a concern with some Osteo Bi-Flex products. Also, some people have allergic reactions to glucosamine (which can be derived from shellfish) or chondroitin.
  • Pregnant or nursing: It is recommended that people who are pregnant or nursing should consult their healthcare provider before taking any Osteo Bi-Flex products.
  • Drug interactions: It seems that there are few drug interactions to be concerned with when taking Osteo Bi-Flex. The anticoagulants Coumadin (warfarin) and Miradon (anisindione) are two that have been noted. If you take any medications, check with your healthcare provider before taking Osteo Bi-Flex.

A Word From Verywell

Many people dealing with osteoarthritis have found some relief through the regular use of Osteo Bi-Flex. It is available in a variety of formulas, and most require just one or two caplets to be taken daily.

The American College of Rheumatology notes that these products might not work for everyone and emphasizes that since these products are not checked by the FDA, they might have serious side effects.

While there are studies that back up the benefits of some ingredients found in Osteo Bi-Flex, the supplements themselves have not been tested. Now that you know what's inside this supplement, you can have an informed conversation with your healthcare provider about whether they're right for you.

Frequently Asked Questions

  • What is Osteo Bi-Flex?

    Osteo Bi-Flex is a nutritional supplement promoted to improve joint health. It is primarily marketed for people with osteoarthritis in the knee joint.

  • What are the key ingredients of Osteo Bi-Flex?

    The main ingredient is a proprietary blend called Joint Shield, which contains an herbal extract—5-Loxin—that may help to reduce pain and improve joint mobility in people with osteoarthritis in the knee. 

    Other compounds in Osteo Bi-Flex include glucosamine, chondroitin, collagen, and methylsulfonylmethane (MSM). 

  • Does Osteo Bi-Flex repair joint damage?

    Possibly, but not likely. Research into individual ingredients of Osteo Bi-Flex suggests they may have beneficial effects on joint health, improve mobility, and reduce pain over time. However, there have not been any clinical trials that have compared before and after imaging studies (such as X-rays) to confirm the compounds in Osteo Bi-Flex can reverse joint damage. 

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8 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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