What Is Reversible Cerebral Vasoconstriction Syndrome?

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Reversible cerebral vasoconstriction syndrome (RCVS) is a rare condition but a true emergency. In RCVS, blood vessels in the brain suddenly narrow, or constrict. These vessels carry oxygen and nutrients to the brain. A stroke may occur as a result, but the "reversible" in RCVS means that symptoms often go away.

The main feature of RCVS is a "thunderclap" headache. This is a sudden, severe, and disabling form of headache. It primarily affects women at middle age, and is often associated with childbirth. In recent years, scientists have found other reasons for why someone may have RCVS episodes.

This article looks at exactly what RCVS is and its common symptoms and risk factors. It explains why RCVS may be different from other kinds of strokes, and discusses how RCVS is diagnosed and treated.

Woman undergoing CT scan
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RCVS and Stroke

An RCVS, sometimes known as Call-Fleming syndrome, may or may not lead to a stroke. In many cases, stroke symptoms occur but are completely reversed later. However, some people may be left with permanent effects. An RCVS event also may cause seizures and death.

Strokes caused by damage to blood vessels in the brain fall into two categories. Ischemic strokes happen when blood flow is blocked, usually by a blood clot. Hemorrhagic strokes happen when the blood vessel itself is damaged. RCVS can cause either type, but it's usually linked to a subarachnoid hemorrhage. This refers to bleeding between the brain itself and the membrane that surrounds it.

RCVS is not the same thing as a transient ischemic attack, or TIA, even though they may seem alike. TIAs are "warning strokes," in that they cause stroke symptoms but resolve without causing any lasting damage. TIAs are strong predictors of stroke but happen for different reasons.


The severe "thunderclap" headache is the hallmark sign of RCVS and it may be the only symptom. The definition of this type of headache includes:

  • Abrupt onset without warning
  • Intensity peaks in less than 60 seconds
  • Lasts at least five minutes
  • Often referred to as the "worst headache of your life"

Some people report a surge of high blood pressure when the headache comes on. A person having an RCVS event also may have a seizure at the time.


The cause of RCVS is not known, but it may be linked to a temporary change in an arterial wall. This leads to the blood vessel narrowing. RCVS may happen more than once, though this is rare.

It occurs more often in middle-aged women, usually under the age of 50, and is linked to childbirth. In some cases, doctors have reported RCVS episodes in people with pheochromocytoma. This rare condition is associated with high blood pressure.

There have also been cases that appear linked to exertion, including sexual activity, or to physical activities as simple as bathing or coughing.

Several medications and street drugs also are linked with RCVS. They include:

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Nasal decongestants containing pseudoephedrine or ephedrine
  • Ergotamine
  • Tacrolimus
  • Nicotine patches
  • Cocaine
  • Cannabis


Constricted blood vessels can be diagnosed using a range of imaging techniques. For RCVS, an imaging technique called cerebral catheter digital subtraction angiography (DSA) is considered the gold standard.

However, many other tests may also be options. They include computed tomography (CT), which may be the first image available when someone with RCVS arrives in the emergency room. Other imaging tests include:

A final diagnosis will factor in the individual signs and symptoms of the person with a possible RCVS episode, as well as any trigger for RCVS that's been identified. Doctors also may use an RCVS score that includes a person's history of "thunderclap" headaches. The score also looks at whether there is a brain bleed, if the carotid intracranial artery is involved, and any information about trigger events.


In many cases, RCVS will resolve by itself. But there are some cases that may be linked to an underlying medical condition. Treatment will depend on what your doctor has learned about the potential causes.

If RCVS does lead to a stroke, seizure, or other medical issue, health workers will treat that problem.


RCVS is a relatively rare condition that occurs when blood vessels in the brain suddenly constrict, causing stroke-like symptoms. There are no lasting impacts in many cases, which is why it is thought "reversible." But it can lead to a stroke or result in permanent stroke-like deficits, so an episode is a serious event that requires medical attention.

Why RCVS happens is not entirely known, though it's been linked to childbirth, physical stress, trauma, and certain medications and drugs. Treatment depends on the underlying cause and any lasting effects. Ask your doctor about RCVS if you have concerns about your own risks.

A Word From Verywell

Doctors aren't always sure what causes RCVS but the research generally agrees on one thing: RCVS is underdiagnosed and gets missed in a lot of cases. So if you or a loved one have symptoms, or an episode that seems consistent with RCVS, don't dismiss it as a passing thing. Be sure to take it seriously and call your doctor to get checked out.

6 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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  2. Centers for Disease Control and Prevention. Types of stroke.

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  4. Cho S, Lee MJ, Gil YE, et al. RCVS–TCH score can predict reversible cerebral vasoconstriction syndrome in patients with thunderclap headacheSci Rep. 2021;11(1):7750. doi: 10.1038/s41598-021-87412-7

  5. Burton TM, Bushnell CD. Reversible cerebral vasoconstriction syndrome: a diagnostic imaging reviewStroke. 2019;50(8):2253-2258. doi: 10.1161/STROKEAHA.119.024416

  6. Rocha EA, Topcuoglu MA, Silva GS, et al. RCVS 2 score and diagnostic approach for reversible cerebral vasoconstriction syndromeNeurology. 2019;92(7):e639-e647. doi: 10.1212/WNL.0000000000006917

By Jose Vega MD, PhD
Jose Vega MD, PhD, is a board-certified neurologist and published researcher specializing in stroke.