Superior Vena Cava (SVC) Syndrome Overview

Symptoms, Causes, and Treatment

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In This Article

Superior vena cava (SVC) syndrome is a set of symptoms that result when blood flow through the superior vena cava (the large blood vessel that returns blood from the upper body back to the heart) is blocked. These include swelling of the face, arms, neck, and chest, distention of veins in the neck, and sometimes shortness of breath and a cough. SVC syndrome is usually diagnosed with a chest CT scan, but further tests may be done as well. Treatment focuses on the underlying cause, which means treating lung cancer which is often present. It may also include bypassing the obstruction that causes the syndrome.

SVC syndrome is a complication that occurs in 2 percent to 4 percent of people living with lung cancer, and in some cases is the first symptom that leads to the diagnosis. It is most common with tumors that grow near the top of the lungs, and because of the location of these tumors, they can easily be missed on a chest X-ray.


The symptoms of SVC syndrome are caused by the buildup of pressure in the superior vena cava above the blockage. The superior vena cava drains blood from the head and neck, arms, and upper chest, and blockage may result in the backup of blood in veins in these regions. Possible signs and symptoms may include:

  • Swelling of the face, arms, or chest wall
  • Difficulty breathing (dyspnea)
  • Widening (distention) of the veins in the neck and chest
  • Redness of the face, neck, and palms of the hands
  • Cough and/or coughing up blood (hemoptysis)
  • Headache
  • Chest pain
  • Hoarseness
  • Difficulty swallowing (dysphasia)
  • Bluish tinge to the skin of the face or upper body (cyanosis)
  • Horner's syndrome (a constricted pupil, saggy eyelid, and lack of sweating on one side of the face)

When It's an Emergency

Superior vena cava syndrome may occur gradually in many patients but can be a cancer-related medical emergency in some situations. If the obstruction of the superior vena cava occurs rapidly, there may not be time for other blood vessels (called collateral blood vessels or circulation) to accommodate the increased blood flow that takes place. Most worrisome is lung-cancer-induced SVC syndrome which causes obstruction of the trachea, the airway that travels from the nose to the large bronchi which enter the lung.

If you are experiencing any of the symptoms noted above, it's important to make an appointment to see your doctor right away. And even if you feel it is related to your cancer, it's important to talk to your doctor. In addition, there may be medical conditions aside from cancer that are causing this problem.


The most common cause of SVC syndrome today is compression of the superior vena cava (SVC) by a cancerous tumor. The superior vena cava is a soft-walled vein and can be easily compressed by tumors growing nearby. Lung cancers, especially those growing in the right upper lung, are the most common cause, followed by lymphomas. The spread of other tumors, such as breast cancer to lymph nodes in the mediastinum (the area of the chest between the lungs) can also be responsible. Cancers such as testicular cancer, thymus cancer, and thyroid cancer may also lead to the syndrome.

Less common causes include blood clots within the SVC (often secondary to central intravenous lines or pacemaker wires), aortic aneurysms, or infections like tuberculosis or histoplasmosis.


SVC syndrome is often suspected by the signs and symptoms noted above. Radiological studies such as a chest X-ray or CT scan may show a tumor or signs suggestive of SVC syndrome. Other tests, such as an MRI, ultrasound, or venography (a test done using a dye to X-ray veins) may be recommended as well. If your doctor suspects a cancer is causing your symptoms (and you are otherwise stable medically), further tests are then needed to diagnose the cancer before treatment is started.


The treatment of SVC syndrome depends in large part upon the cause. If symptoms are due to a tumor pushing on the superior vena cava, methods to treat the tumor such as chemotherapy, targeted therapies, surgery, immunotherapy, or radiation therapy are often used. With lymphomas, treatments such as monoclonal antibodies may be used. With SVC syndrome due to metastases, treatment usually involves treating the primary cancer.

Depending on the severity of your symptoms, a stent may be placed to hold the superior vena cava open. Blood thinners may be used to prevent clotting. In rare cases, surgery to bypass the obstruction may be needed.

To rapidly improve symptoms pending definitive treatment, management often includes keeping the head elevated, giving corticosteroids to reduce inflammation, and giving diuretics ("water pills") to reduce swelling.

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Article Sources
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