Brain & Nervous System Headaches Symptoms What Is Trigeminal Neuralgia? By Colleen Doherty, MD Colleen Doherty, MD Colleen Doherty, MD, is a board-certified internist living with multiple sclerosis. Learn about our editorial process Updated on April 24, 2022 Medically reviewed by Diana Apetauerova, MD Medically reviewed by Diana Apetauerova, MD LinkedIn Diana Apetauerova, MD, is board-certified in neurology with a subspecialty in movement disorders. She is an associate clinical professor of neurology at Tufts University. Learn about our Medical Expert Board Print Table of Contents View All Table of Contents Symptoms Causes Diagnosis Treatment Coping Trigeminal neuralgia (a.k.a. tic douloureux) is a relatively rare facial pain syndrome. It affects a nerve in the head called the trigeminal nerve, which provides sensation to the face. The condition causes repeated episodes of sudden, extreme, electric-shock–like pain on the side of the face. Trigeminal neuralgia pain cycles can last months. It can also lead to anxiety over when the pain will return. This article discusses trigeminal neuralgia symptoms and causes. It also covers the diagnosis and treatment of the condition and ways to cope. Denis Kartavenko / Getty Images Trigeminal Neuralgia Symptoms Severe facial pain that comes on abruptly is the main symptom of trigeminal neuralgia. The pain is often described as intensely sharp, stabbing, or electric shock-like. It occurs as repetitive bursts of pain that may last for a few seconds or up to two minutes. The bursts come on more frequently until the pain is almost constant. Pain flare-up cycles can persist for a few weeks or months, followed by extended pain-free periods that last months or even years. What Is the Trigeminal Nerve? The trigeminal nerve is a cranial nerve (i.e., a nerve in the head). It starts at the ear and runs along both sides of the face in three branches: Above the eye socket: the ophthalmic branch Along the cheekbone: the maxillary branch Along the jaw: the mandibular branch The nerve sends sensory information from the face to the brain and helps control the chewing muscles. Trigeminal neuralgia can affect any part of the face, but it is most common on the branches of the trigeminal nerve that run along the cheek and jaw. Typically, only one side of the face is effected. The pain is often mistaken for toothache. Some people undergo painful and unnecessary dental procedures before getting an accurate diagnosis. The course of a trigeminal neuralgia pain cycle is unpredictable. This can lead to anxiety and worry over when the next flare-up will strike. Common Pain Triggers During a pain cycle, certain common activities can trigger an episode of trigeminal neuralgia pain. These include: Brushing your teethChewingExposure of your face to cold airLight touching of the faceShavingSmilingTalking or laughingWater running on your faceWind or breeze on your face Recap The facial pain of trigeminal neuralgia comes on suddenly and is intense, stabbing, or like an electric shock. Bouts repeat in cycles that become more frequent and last for weeks or months. Flares can recur even after long periods of no symptoms. Causes Trigeminal neuralgia is caused by compression of the trigeminal nerve root. Compression can occur from: An abnormal loop of an artery or vein in the face A cyst or tumor, like an acoustic neuroma or meningioma (rare) Inflammation of the nerve from a condition such as multiple sclerosis The initial flare-up of trigeminal neuralgia often has no obvious cause. However, it can start after a car accident, dental work, or a blow to the face in some people. Risk Factors Trigeminal neuralgia is more common in some demographics than others. While it can affect people of any age, race, or sex, it is more likely to affect: FemalesPeople over the age of 50People with multiple sclerosis Trigeminal neuralgia does not typically run in families and is not believed to have a genetic component. However, about 2% of cases are found in people with a close relative with the condition. This is known as familial trigeminal neuralgia. Diagnosis Trigeminal neuralgia is typically diagnosed by a neurologist. Brain imaging, like magnetic resonance imaging (MRI), is often used to rule out other causes. Conditions that trigeminal neuralgia may be confused with include: Acute herpes zoster (shingles) Postherpetic neuralgia Trauma to the trigeminal nerve Temporomandibular joint dysfunction (TMJ) Dental-related pain A headache disorder, such as primary stabbing headache or cluster headaches About 150,000 people in the United States are diagnosed with trigeminal neuralgia each year. Treatment Trigeminal neuralgia is usually treated with an anti-seizure medication called Tegretol (carbamazepine). While often effective, it does have side effects, which are worsened with higher doses. Side effects include: DrowsinessDizzinessNauseaVomiting Some people are unable to take carbamazepine due to more serious adverse effects. These can include: A significant decrease in the number of white blood cells (infection-fighting cells) after taking carbamazepine Aplastic anemia, a disorder that affects your bone marrow, where blood cells are produced (rare) Stevens-Johnson syndrome, also known as toxic epidermal necrolysis, a potentially fatal skin disorder People of Asian descent, in particular, are at increased risk for Stevens-Johnson syndrome. Your healthcare provider may test you for a genetic marker before prescribing carbamazepine. If you are unable to take carbamazepine, your healthcare provider may prescribe other medications. These include: Trileptal (oxcarbazepine), which is similar in structure to carbamazepine and may have fewer side effectsBaclofen, a muscle relaxerLamictal (lamotrigine), a medicine used to treat seizures and bipolar disorder Specialist-Driven Procedures If you continue to be affected by trigeminal neuralgia despite medical therapy, or if you cannot tolerate the side effects of medications, your neurologist may refer you for surgery. Surgical treatments for trigeminal neuralgia include: Microvascular decompression: An open surgery that involves removal of a piece of the skull (craniotomy) to find and move the blood vessel compressing the trigeminal nerve. This is the most effective option, but also the most invasive. Percutaneous radiofrequency rhizotomy: The surgeon sends a heating current through a hollow needle inserted into the trigeminal nerve. This destroys nerve fibers and suppresses pain signals. Percutaneous balloon compression: The surgeon threads a balloon through a needle inserted into the cheek. The balloon is inflated to compress the nerve, injuring pain-causing fibers. Percutaneous glycerol rhizotomy: Glycerol, a clear and thick liquid, is injected into the trigeminal nerve. This damages the nerve to interfere with the transmission of pain signals. Stereotactic radiosurgical procedures: Gamma Knife, Cyberknife, and Linear Accelerator (LINAC) are non-invasive procedures. They deliver a single, highly concentrated dose of ionizing radiation to the trigeminal nerve root. Neuromodulation: In peripheral nerve stimulation, motor cortex stimulation, and deep brain stimulation, electrodes are placed under the skull in the tissue near the nerve. Electrical stimulation is delivered to the parts of the brain responsible for sensations in the face. This relieves trigeminal neuralgia pain. Alternative Treatments Some people with trigeminal neuralgia find relief with complementary and alternative medicine therapies. These include: Acupuncture Biofeedback Chiropractic Cognitive-behavioral therapy (CBT) Nutrition therapy Vitamin therapy However, there is little or no evidence to support any of these approaches for trigeminal neuralgia pain relief. They may, however, help relieve anxiety and depression associated with trigeminal neuralgia flare-ups. Recap Trigeminal neuralgia is commonly treated with medications used to treat seizures and muscle relaxers. If you cannot take these or they fail to work, surgery may be recommended. While some may find relief from alternative treatments, there is little evidence to show they help. Coping Living with trigeminal neuralgia can be unpredictable. Many people who live with this painful condition often experience anxiety, worrying over when the pain will strike next. Mind-body exercises, such as yoga, meditation, aromatherapy, and visualization, can lower your anxiety and help you cope better. Support groups focused on people who live with facial pain syndromes or chronic pain can help you learn additional coping techniques and feel less alone. These resources are good places to start: Facial Pain Association offers support groups and peer mentors online and in-person in some areas. Chronic Pain Anonymous is a 12-step fellowship that has meetings online and in-person in some areas. Facebook groups, such as Trigeminal Neuralgia Support, Trigeminal Neuralgia and Face Pain, and Trigeminal Neuralgia Sufferers and Supporters, offer peer-to-peer support. Summary Trigeminal neuralgia is an extremely painful condition that causes waves of sharp facial pain. It is usually caused by compression on the trigeminal nerve, which runs alongside the face. Pain cycles get increasingly more intense and can last days to weeks. Patients can go long durations without pain only to have the condition flare again. Seizure medications or muscle relaxers may be recommended. In some cases, surgery is needed to end the pain. Mind-body therapies and support can help you cope with worry about your next flare. 7 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Johns Hopkins Medicine. Trigeminal neuralgia. Zakrzewska JM, Linksey ME. Trigeminal neuralgia. BMJ. 2014;348:g474. doi:10.1136/bmj.g474 American Association of Neurological Surgeons. Trigeminal neuralgia. Cleveland Clinic. Trigeminal neuralgia. Fernández Rodríguez B, Simonet C, Cerdán DM, Morollón N, Guerrero P, Tabernero C, Duarte J. Familial classic trigeminal neuralgia. Neurologia (Engl Ed). 2019;34(4):229-233. English, Spanish. doi:10.1016/j.nrl.2016.12.004 Al-Quliti KW. Update on neuropathic pain treatment for trigeminal neuralgia. The pharmacological and surgical options. Neurosciences (Riyadh). 2015;20(2):107–14. doi:10.17712/nsj.2015.2.20140501 Bae HM, Park YJ, Kim YH, Moon DE. Stevens-Johnson syndrome induced by carbamazepine treatment in a patient who previously had carbamazepine induced pruritus - a case report . Korean J Pain. 2013;26(1):80–3. doi:10.3344/kjp.2013.26.1.80 Additional Reading Bajwa ZH, Ho CC, Khan SA. (2018). Trigeminal neuralgia. Shefner JM, Swanson JW, eds. UpToDate. Waltham, MA: UpToDate Inc. Gronseth G, Cruccu G, Alksne J, Argoff C, Brainin M, Burchiel K, et al. Practice parameter: the diagnostic evaluation and treatment of trigeminal neuralgia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology and the European Federation of Neurological Societies. Neurology. 2008;71:1183-1190. doi: 10.1212/01.wnl.0000326598.83183.04 Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 3rd Edition (beta version). Cephalalgia 2013;24(9):629-808. doi: 10.1177/0333102413485658 By Colleen Doherty, MD Colleen Doherty, MD, is a board-certified internist living with multiple sclerosis. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit