Supplements Antioxidants What Is Hesperidin? The Citrus Antioxidant May Boost Heart Health By Cathy Wong Cathy Wong Facebook Twitter Cathy Wong is a nutritionist and wellness expert. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Learn about our editorial process Updated on March 19, 2021 Medically reviewed Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Arno Kroner, DAOM, LAc Medically reviewed by Arno Kroner, DAOM, LAc Facebook LinkedIn Twitter Arno Kroner, DAOM, LAc, is a board-certified acupuncturist, herbalist, and integrative medicine doctor practicing in Santa Monica, California. Learn about our Medical Expert Board Print Verywell / Anastasia Tretiak Table of Contents View All Table of Contents What Is Hesperidin Used For? Possible Side Effects Dosage and Preparation What to Look For Hesperidin is a bioflavonoid, a type of plant pigment with antioxidant and anti-inflammatory effects found primarily in citrus fruit. Oranges, grapefruit, lemon, and tangerines all contain hesperidin, which is also available in supplement form. Hesperidin is purported to provide a wide range of health benefits, ranging from cancer treatment to hot flash relief. Not all of these benefits are supported by strong scientific research. What Is Hesperidin Used For? Hesperidin is thought to have beneficial effects on blood vessels. It's touted as a natural remedy for a number of health problems, including allergies, hemorrhoids, high blood pressure, hot flashes, hay fever, sinusitis, symptoms associated with menopausal changes, premenstrual syndrome, and varicose veins. Hesperidin is also said to improve circulation, reduce inflammation, and help fight cancer. Research on the health effects of hesperidin is fairly limited. However, there's some evidence that hesperidin may offer certain benefits. Here's a look at some key study findings. Heart Health Consumption of citrus fruit has been associated with a reduced risk of cardiovascular disease. Several clinical trials exploring hesperidin's effect on cardiovascular disease markers have yielded mixed results. A 2016 study published in the American Journal of Clinical Nutrition, for instance, investigated the effect of six weeks of hesperidin supplementation on blood vessels in men and women who were overweight. While there was no significant change in flow-mediated dilation (a test used to measure artery, or endothelial, function), the subset of people with relatively healthy endothelial function saw further significant improvement in endothelial function after eating a high-fat meal compared to those who took a placebo. In addition, regular hesperidin consumption may decrease blood pressure and improve blood vessel function, suggests a study conducted with overweight men published in the American Journal of Clinical Nutrition in 2011. After four weeks of daily consumption of orange juice or a hesperidin beverage, participants' diastolic blood pressure was significantly lower, and their endothelial function (after eating a meal) had significantly improved. Hesperidin also shows promise for people who have had a heart attack, suggests a study published in the Journal of the American College of Nutrition in 2015. For the study, people who'd experienced a heart attack took either a hesperidin supplement or a placebo for four weeks. At the study's end, those who took the hesperidin had significantly decreased levels of some inflammatory markers. Cognitive Health Consumption of 100% orange juice, which is naturally bioflavonoid-rich, may benefit cognitive function in healthy older adults, according to a small study published in the American Journal of Clinical Nutrition in 2015. Cognitive function was significantly better after eight weeks of consuming pure, unadulterated orange juice compared to eight weeks of a low-bioflavonoid orange-flavored drink. Hemorrhoids In a 2015 study in Techniques in Coloproctology, a supplement containing a combination of bioflavonoids (hesperidin, diosmin, and troxerutin) was found to aid in the treatment of hemorrhoids. For the study, 134 people with acute hemorrhoids were treated with either the hesperidin-diosmin-troxerutin combination or a placebo for 12 days. Compared to those taking the placebo, people who took the bioflavonoids experienced a significant reduction in pain and bleeding. The proportion of people who reported the persistence of swelling and thrombosis also decreased significantly. After six days, the amount of oral pain medication needed by those taking the bioflavonoids was also lower. Possible Side Effects Hesperidin may trigger a number of side effects, including abdominal pain, diarrhea, contact dermatitis, and nausea. Hesperidin supplements may not be safe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers). Therefore, it's important to consult your physician if you're considering using hesperidin in combination with other medications. Clinical research suggests that hesperidin may affect blood clotting and increase the risk of bleeding. People taking anticoagulant/antiplatelet medications and those with bleeding disorders shouldn't take hesperidin. In addition, it's safest to avoid hesperidin and foods, such as citrus, containing it within two weeks of surgery (before and after). There was a reported case of thrombocytopenic purpura (a disorder that can lead to easy or excessive bleeding or bruising) associated with the use of two supplements containing mainly citrus bioflavonoids. Keep in mind that self-treating a condition and avoiding or delaying standard care may have serious consequences. In addition, the safety of many supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established. Verywell / Anastasia Tretiak Dosage and Preparation There is not enough scientific data to provide a recommended dose of hesperidin. Various doses have been used in clinical studies of the supplement. For example, to investigate hesperidin's role in improving circulation in the legs, a product containing 150 mg of hesperidin methyl chalcone, 150 mg of butcher's broom root extract, and 100 mg of ascorbic acid was used. More generally, dosages of 50-150 mg have typically been used in studies, although some studies have used upward of 600 mg over a period of 4-12 weeks. However, the safety of long-term use of any of these amounts has not been sufficiently studied or established. The appropriate dose for you may depend on factors including your age, gender, and medical history. Speak to your healthcare provider to get personalized advice. What to Look For You can increase your intake of hesperidin by consuming more lemons, limes, sweet oranges, tangerines, and grapefruit. Fresh and dried forms of the herb peppermint are another significant dietary source. Some people buy hesperidin supplements in health food stores or online. Since supplements are largely unregulated in the United States, keep in mind that when you take a purchased supplement, you may get ingredients other than hesperidin. The National Institutes of Health (NIH) recommends that you look for a Supplement Facts label on a product before you buy. This label will contain vital information, including the amount of active ingredients per serving and other added ingredients like fillers, binders, and flavorings. The NIH suggests that you look for a product that contains a seal of approval from a third-party organization that provides quality testing. These organizations include U.S. Pharmacopeia, ConsumerLab.com, and NSF International. A seal of approval from one of these organizations does not guarantee the product's safety or effectiveness, but it does provide assurance that the product was properly manufactured, contains the ingredients listed on the label, and does not contain harmful levels of contaminants. A Word From Verywell While increasing your intake of citrus fruits may be of some benefit, doing so shouldn't be used as a substitute for medical treatment or overall healthy lifestyle practices. If you're thinking of trying hesperidin, speak with your primary care provider to weigh the pros and cons and discuss whether it's appropriate for you. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit 10 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Mahmoud AM, Bautista RJH, Sandhu MA, Hussein OE. Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health. Oxidative Medicine and Cellular Longevity. 2019;2019:1-19. doi:10.1155/2019/5484138 Li C, Schluesener H. Health-promoting effects of the citrus flavanone hesperidin. Critical Reviews in Food Science and Nutrition. 2015;57(3):613-631. doi:10.1080/10408398.2014.906382 Mahmoud AM, Hernández Bautista RJ, Sandhu MA, Hussein OE. Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health. Oxid Med Cell Longev. 2019;2019:5484138. doi:10.1155/2019/5484138 Salden BN, Troost FJ, Groot ED. Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals. The American Journal of Clinical Nutrition. 2016;104(6):1523-1533. doi:10.3945/ajcn.116.136960 Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr. 2011;93(1):73-80. doi:10.3945/ajcn.110.004945 Haidari F, Heybar H, Jalali MT, Engali KA, Helli B, Shirbeigi E. Hesperidin Supplementation Modulates Inflammatory Responses Following Myocardial Infarction. Journal of the American College of Nutrition. 2015;34(3):205-211. doi:10.1080/07315724.2014.891269 Kean RJ, Lamport DJ, Dodd GF. Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults. The American Journal of Clinical Nutrition. 2015;101(3):506-514. doi:10.3945/ajcn.114.088518 Giannini I, Amato A, Basso L. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial. Techniques in Coloproctology. 2015;19(6):339-345. doi:10.1007/s10151-015-1302-9 Aguilar peralta GR, Arévalo gardoqui J, Llamas macías FJ, Navarro ceja VH, Mendoza cisneros SA, Martínez macías CG. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. Int Angiol. 2007;26(4):378-84. Lv X, Zhao S, Ning Z. Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health. Chem Cent J. 2015;9:68. doi:10.1186/s13065-015-0145-9 Additional Reading Hesperidin. Natural Medicines Database. Professional Monograph.