The Health Benefits of Hesperidin

The Citrus Antioxidant May Boost Heart Health

People drinking orange juice
Food sources of hesperidin include orange juice. Betsie Van Der Meer/Taxi/Getty Images

Hesperidin is a bioflavonoid, a type of plant pigment with antioxidant and anti-inflammatory effects found primarily in unripe citrus fruit. Oranges, grapefruit, lemon, and tangerines contain hesperidin, and it is also available in supplement form. 

Hesperidin is purported to provide a wide range of health benefits ranging from cancer treatment to hot flash relief. Not all of these benefits are supported by strong scientific research.

Health Benefits

Hesperidin is thought to have beneficial effects on blood vessels. It's touted as a natural remedy for a number of health problems, including allergieshemorrhoidshigh blood pressure, hot flashes, hay fever, sinusitis, symptoms associated with menopausal changes, premenstrual syndrome, and varicose veins. Hesperidin is also said to improve circulation, reduce inflammation, and help fight cancer.

Research on the health effects of hesperidin is fairly limited. However, there's some evidence that hesperidin may offer certain benefits. Here's a look at some key study findings:

Heart Health

Consumption of citrus fruit has been associated with a reduced risk of cardiovascular disease. Several clinical trials exploring hesperidin's effect on cardiovascular disease markers have yielded mixed results.

A 2016 study published in the American Journal of Clinical Nutrition, for instance, investigated the effect of six weeks of hesperidin supplementation on blood vessels in people who were overweight. While there was no significant change in flow-mediated dilation (a test used to measure artery, or endothelial, function) overall, the subset of people with relatively healthy endothelial function had significant improvement after eating a high-fat meal compared to those who took the placebo.

A single dose of hesperidin may not reduce cardiovascular risk markers in men at moderate heart disease risk, suggests a 2015 study published in the American Journal of Clinical Nutrition. After a single dose of hesperidin from orange juice or a supplement, no effects were observed on cardiovascular risk markers (such as endothelial function, blood pressure, and artery stiffness). 

However, regular hesperidin consumption may decrease blood pressure and improve blood vessel function in people who are overweight, suggests a study published in the American Journal of Clinical Nutrition in 2015. After four weeks of daily consumption of orange juice or a hesperidin beverage, participants' diastolic blood pressure was significantly lower and endothelial function (after eating a meal) was significantly improved.

Hesperidin shows promise for people who have had a heart attack, suggests a study published in the Journal of the American College of Nutrition in 2015. For the study, people who had a myocardial infarction took either a hesperidin supplement or a placebo for four weeks. At the study's end, those who took the hesperidin had significantly decreased levels of some of the inflammatory markers.

Cognitive Health

Consumption of a citrus bioflavonoid-rich orange juice may benefit cognitive function in healthy older adults, according to a small study published in the American Journal of Clinical Nutrition in 2015. Cognitive function was significantly better after eight weeks consumption of a bioflavonoid-rich juice compared to eight weeks of a low-bioflavonoid drink. 


In a 2015 study in Techniques in Coloproctology, a supplement containing a combination of bioflavonoids (hesperidin, diosmin, and troxerutin) was found to aid in the treatment of hemorrhoids. For the study, 134 people with acute hemorrhoids were treated with either the hesperidin/diosmin/troxerutin combination or a placebo for 12 days.

Compared to those taking the placebo, people who took the bioflavonoids experienced a significant reduction in pain and bleeding. The proportion of people who reported the persistence of swelling and thrombosis also decreased significantly. After six days, the amount of oral pain medication taken by those taking the bioflavonoids was also lower. 

Possible Side Effects

Hesperidin may trigger a number of side effects, including abdominal pain, diarrhea, contact dermatitis, and nausea.

Hesperidin supplements may not be safe for people taking certain medications (including anticoagulants, blood pressure drugs, and calcium channel blockers). Therefore, it's important to consult your physician if you're considering using hesperidin in combination with other medications. 

Clinical research suggests that hesperidin may affect blood clotting and increase the risk of bleeding. People taking anticoagulant/antiplatelet medications, those with bleeding disorders, and people two weeks before or after surgery shouldn't take hesperidin.

There was a reported case of thrombocytopenic purpura(a disorder that can lead to easy or excessive bleeding or bruising) associated with the use of two supplements containing mainly citrus bioflavonoids.

Supplements haven't been tested for safety and due to the fact that dietary supplements are largely unregulated, the content of some products may differ from what is specified on the product label. Also keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established.

You can also get tips on using supplements here, but keep in mind that self-treating a condition and avoiding or delaying standard care may have serious consequences.

Dosage and Preparation

There is not enough scientific data to provide a recommended dose of hesperidin. Various doses have been used in clinical studies of the supplement.

For example, to investigate hesperidin's role in improving circulation in the legs, a product containing hesperidin methyl chalcone 150 mg, butcher's broom root extract 150 mg, and ascorbic acid 100 mg was used. Also, a combination of 100-150 mg of hesperidin with 900-1350 mg of diosmin taken daily for up to six months was also used. And to investigate the supplement's effect on hemorrhoids, various combinations that included 50-150 mg of hesperidin were used.

The appropriate dose for you may depend on factors including your age, gender, and medical history. Speak to your healthcare provider to get personalized advice.

What to Look For

You can increase your intake of hesperidin by consuming more lemons, sweet oranges, limes, and grapefruit. Certain other foods, such as peppermint are also sources.

Many people buy hesperidin supplements in health food stores or online. Keep in mind that when you take a purchased supplement, you may get ingredients other than hesperidin. The National Institutes of Health (NIH) recommends that you look for a Supplement Facts label on the product that you buy. This label will contain vital information including the amount of active ingredients per serving, and other added ingredients like fillers, binders, and flavorings.

The organization also suggests that you look for a product that contains a seal of approval from a third party organization that provides quality testing. These organizations include U.S. Pharmacopeia,, and NSF International. A seal of approval from one of these organizations does not guarantee the product's safety or effectiveness but it does provide assurance that the product was properly manufactured, contains the ingredients listed on the label, and does not contain harmful levels of contaminants.

Lastly, Keep in mind that while increasing your intake of citrus fruits may be of some benefit, they shouldn't be used as a substitute for treatment or healthy lifestyle practices. If you're still thinking of trying hesperidin, be sure to speak with your primary care provider first to weigh the pros and cons and discuss whether it's appropriate for you.

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Article Sources
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  1. Mahmoud AM, Bautista RJH, Sandhu MA, Hussein OE. Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic HealthOxidative Medicine and Cellular Longevity. 2019;2019:1-19. doi:10.1155/2019/5484138

  2. Li C, Schluesener H. Health-promoting effects of the citrus flavanone hesperidinCritical Reviews in Food Science and Nutrition. 2015;57(3):613-631. doi:10.1080/10408398.2014.906382

  3. Mahmoud AM, Hernández Bautista RJ, Sandhu MA, Hussein OE. Beneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic HealthOxid Med Cell Longev. 2019;2019:5484138. Published 2019 Mar 10. doi:10.1155/2019/5484138

  4. Salden BN, Troost FJ, Groot ED. Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individualsThe American Journal of Clinical Nutrition. 2016;104(6):1523-1533. doi:10.3945/ajcn.116.136960

  5. Haidari F, Heybar H, Jalali MT, Engali KA, Helli B, Shirbeigi E. Hesperidin Supplementation Modulates Inflammatory Responses Following Myocardial InfarctionJournal of the American College of Nutrition. 2015;34(3):205-211. doi:10.1080/07315724.2014.891269

  6. Schär MY, Curtis PJ, Hazim S. Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular diseaseThe American Journal of Clinical Nutrition. 2015;101(5):931-938. doi:10.3945/ajcn.114.104364

  7. Kean RJ, Lamport DJ, Dodd GF. Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adultsThe American Journal of Clinical Nutrition. 2015;101(3):506-514. doi:10.3945/ajcn.114.088518

  8. Giannini I, Amato A, Basso L. Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trialTechniques in Coloproctology. 2015;19(6):339-345. doi:10.1007/s10151-015-1302-9

  9. Durgadevi Nardarajah. Hesperidin-A short Review. Research J. Pharm. and Tech. 7(1): Jan. 2014; Page 78-80.

  10. Aguilar peralta GR, Arévalo gardoqui J, Llamas macías FJ, Navarro ceja VH, Mendoza cisneros SA, Martínez macías CG. Clinical and capillaroscopic evaluation in the treatment of chronic venous insufficiency with Ruscus aculeatus, hesperidin methylchalcone and ascorbic acid in venous insufficiency treatment of ambulatory patients. Int Angiol. 2007;26(4):378-84.

  11. Lv X, Zhao S, Ning Z. Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human healthChem Cent J. 2015;9:68. Published 2015 Dec 24. doi:10.1186/s13065-015-0145-9

Additional Reading
  • Hesperidin. Natural Medicines Database. Professional Monograph. 2/13/2019