Digestive Health Diarrhea Print The Antibiotics That Are Most Likely to Cause Diarrhea Medically reviewed by Medically reviewed by Emmy Ludwig, MD on August 29, 2018 Emmy Ludwig, MD, is board-certified in gastroenterology and hepatology. She practices at the Memorial Sloan-Kettering Cancer Center in New York. Learn about our Medical Review Board Emmy Ludwig, MD Written by facebook twitter linkedin Written by Amber J. Tresca Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. She was diagnosed with ulcerative colitis at age 16. Learn about our editorial policy Amber J. Tresca Updated on September 24, 2019 Diarrhea Overview Symptoms Causes Diagnosis Treatment Nutrition Image © Corbis via Getty Images / Getty Images Antibiotics are lifesaving for many people who have bacterial infections. However, antibiotics can have some unintended negative effects, including diarrhea, which can be severe. This article describes the ins and outs of antibiotic-associated diarrhea. Why Antibiotics Cause Diarrhea The first thing to understand is that there are many types of bacteria in our bodies, some of which never cause disease and others that can cause disease sometimes. For the most part, bacteria tend to live in harmony within the intestines and in other surfaces on the body. When antibiotics are introduced into the body, the balance of the bacteria is altered. That alteration changes the way the intestine handles nutrients and fluids and changes its motility. When that happens many people develop some diarrhea. Clostridium Difficile We need beneficial bacteria in our digestive tract, but that doesn't mean that all the bacteria that live there is doing good work for our bodies. There are also harmful bacteria living in the digestive tract. Most of the time, the good strains of bacteria can overtake the harmful strains, keeping the bad stuff in check and preventing it from causing disease. In a small number of people (2% to 3%), a bacteria called Clostridium difficile lives in the colon. In a minority of those people, C difficile may begin to multiply and take over the colon after taking a course of antibiotics. This can, unfortunately, result in C difficile-associated diarrhea (also called pseudomembranous colitis). This disease causes diarrhea and in rare cases may also be associated with toxic megacolon, a life-threatening surgical emergency. Symptoms of C. Difficile Infection The Antibiotics That Can Cause Complications Any antibiotic can disrupt the flora in the large intestine and lead to bacteria die-off there. However, not every type of antibiotic carries the same amount of likelihood of contributing to C difficile colitis. While it's true that taking any antibiotic can result in C difficile colitis, there are some antibiotics that have a higher risk of doing so than others. The antibiotics most responsible for C difficile colitis are the ones that are formulated to kill a wide variety of bacteria, which makes sense, because they are going to have an effect on the most different types of bacteria, including the good ones. Antibiotics and C. Difficile Risk The antibiotics most associated with C. difficile colitis are:CephalosporinsClindamycinFluoroquinolonesPenicillinsThe antibiotics that carry a moderate amount of risk include:ImipenemMacrolidesSulfa-trimethoprimThose antibiotics with the lowest risk are:AminoglycosidesMetronidazoleNitrofurantoin The Role of Probiotics in Preventing Diarrhea Probiotics are widely available in supermarkets and drug stores but they're not all created equally. They may contain different strains of bacteria and different amounts, and they're largely unregulated, though there are some brands that are more reliable than others. What's more, it's not been determined which ones may help, or even how much of them should be taken. Therefore, there's no blanket recommendation about taking probiotics after a course of antibiotics. It's suggested that sometimes a probiotic may help, but it's not going to be true in all cases. The cost of probiotics and the potential harm they can cause must also be considered. For people who have inflammatory bowel disease (IBD), especially those with an ostomy or a j-pouch, it is important to talk to a gastroenterologist about antibiotics. Antibiotics have been associated with IBD flare-ups, and a gastroenterologist may have suggestions about whether a probiotic would be helpful, and which brand to use. A Word From Verywell A bacterial infection may need to be treated with antibiotics, and there may be no way of getting around it. The choice of antibiotics used won't be based on whether or not it has a low risk of C difficile colitis, but rather on what is the right choice for killing the bacteria that are causing the infection. If you have concerns about having problems with diarrhea after taking antibiotics, talk to your physician. In some cases, there may be some leeway with which antibiotic to use, but it has to be effective against the bacteria that is causing the infection. Taking probiotics may be an option to repopulate the colon with good bacteria, but that should be discussed with a physician because again, the right ones need to be chosen. Was this page helpful? Thanks for your feedback! Gas pain? Stool issues? Sign up for the best tips to take care of your stomach. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial policy to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Issa I, Moucari R. "Probiotics for antibiotic-associated diarrhea: Do we have a verdict?" World J Gastroenterol. 2014 Dec 21; 20: 17788–17795. doi: 10.3748/wjg.v20.i47.17788 Sachar DB, Walfish AE. "Clostridium difficile-Induced Colitis." Merck Manual. Sep 2006. Schroeder MS. "Clostridium difficile--associated diarrhea." Am Fam Physician. 1 Mar 2005. Continue Reading