Asthma Treatment How Singulair Side Effects Could Possibly Affect Your Mental Health By Pat Bass, MD twitter linkedin Dr. Bass is a board-certified internist, pediatrician, and a Fellow of the American Academy of Pediatrics and the American College of Physicians. Learn about our editorial process Pat Bass, MD Medically reviewed by Medically reviewed by Sanja Jelic, MD on March 13, 2021 Sanja Jelic, MD is board-certified in pulmonary disease, sleep medicine, critical care medicine, and internal medicine. She is an assistant professor and attending physician at Columbia University College of Physicians and Surgeons in New York, NY. Learn about our Medical Review Board Sanja Jelic, MD Updated on March 13, 2021 Print Corbis via Getty Images / Getty Images Singulair, Accolate, Zyflo, and Zyflo CR have modified their product labeling to include information about certain potential mental health side effects that have been noted in patients using these products. Events that patients and healthcare providers need to be aware of include: Agitation Aggression Anxiousness Dream abnormalities Hallucinations Depression Insomnia Irritability Restlessness Suicidal thinking and behavior Suicide Tremor If you notice any of these side effects you need to make sure that you immediately talk with your prescribing doctor. The FDA has the following recommendations to patients and providers regarding Singulair side effects and side effects of other leukotriene modifiers: Patients and healthcare professionals should be aware of the potential for neuropsychiatric events with these medications. Patients should talk with their healthcare providers if these events occur. Healthcare professionals should consider discontinuing these medications if patients develop neuropsychiatric symptoms. The latest prescribing information for these products can be found on the FDA website. Was this page helpful? Thanks for your feedback! Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Sign Up You're in! Thank you, {{form.email}}, for signing up. There was an error. Please try again. What are your concerns? Other Inaccurate Hard to Understand Submit Article Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. FDA Pediatric Advisory Committee. FDA Briefing Document for the September 27, 2019 Joint Meeting of the Pediatric and Drug Safety and Risk Management Committees. FDA. Published September 27, 2019. Badri T. Montelukast. StatPearls [Internet]. Published October 9, 2019. Philip G, Hustad C, Noonan G, et al. Reports of suicidality in clinical trials of montelukast. J Allergy Clin Immunol. 2009;124(4):691-6.e6. doi:10.1016/j.jaci.2009.08.010 Erdem SB, Nacaroglu HT, Unsal Karkiner CS, Gunay I, Can D. Side Effects of Leukotriene Receptor Antagonists in Asthmatic Children. Iran J Pediatr. 2015;25(5):e3313. doi:10.5812/ijp.3313 Haarman MG, van Hunsel F, de Vries TW. Adverse drug reactions of montelukast in children and adults. Pharmacol Res Perspect. 2017;5(5):e00341. doi:10.1002/prp2.341 Additional Reading Lu CY, Zhang F, Lakoma MD, et al. Asthma Treatments and Mental Health Visits After a Food and Drug Administration Label Change for Leukotriene Inhibitors. Clin Ther. 2015;37(6):1280–1291. doi:10.1016/j.clinthera.2015.03.027