What to Know About Zantac (Ranitidine)

A Histamine Blocker Which Reduces Stomach Acid

In This Article

Zantac (ranitidine) is an over-the-counter drug most commonly used to treat gastroesophageal reflux disease (GERD). Ranitidine is also used to treat other conditions which involve an excess of stomach acid and can prevent the occurrence of stomach and intestinal ulcers. Ranitidine is a drug in the class of histamine-2 blockers and can be taken as a syrup, pill, or efferdose tablet. The most common brand name of ranitidine is Zantac, but also can be found in stores under the labels Wal-Zan and Heartburn Relief. Due to the over-the-counter nature of this drug, many large retailers have developed their versions with ranitidine as the same primary ingredient.

Uses

FDA-approved uses of ranitidine include treatment of duodenal (intestinal) and gastric ulcers, GERD, and erosive esophagitis which have been diagnosed by endoscopy. Another diagnosis for which ranitidine is commonly used is for the treatment of Zollinger-Ellison syndrome, which causes excess production of stomach acid.

Ranitidine has been determined safe for short-term use in treating the aforementioned conditions. It is also safe for individuals to remain on a different dose of ranitidine long-term as part of a maintenance program for these conditions.

Off-Label Uses

One of the off-label uses of ranitidine is as a prophylactic treatment for stress ulcers. In a pediatric population, ranitidine is used off-label as a parenteral treatment for erosive esophagitis and GERD. Another off-label use for ranitidine is to treat erosive esophagitis in newborns.

Before Taking

Ranitidine is considered safe to use by most healthy people experiencing reflux and other acid-related symptoms, as it is available on an over-the-counter basis. This means it is considered a first-line treatment due to its availability.

Precautions and Contraindications

There are no contraindications associated with ranitidine. There are some precautions related to the use of ranitidine in pediatric and geriatric populations, as dosages must be adjusted to accommodate for absorption rates.

Doctors should adjust the dosage of ranitidine in patients with impaired kidney and liver function, as absorption and elimination of the drug goes through these organs. Individuals with porphyria should use ranitidine with caution. Porphyria is a condition which causes excess protein buildup and ranitidine may cause an increase in the symptoms of porphyria. Patients with allergies to ranitidine should not use this drug in any amount.

Other Histamine-2 Antagonists

  • Axid
  • Axid AR
  • Axid Pulvules
  • Heartburn Relief
  • Pepcid
  • Pepcid AC
  • Tagamet
  • Tagamet HB
  • Zantac 150
  • Zantac 150 Efferdose
  • Zantac 25

Dosage

It is recommended that patients with duodenal ulcers take 150 milligrams (mg) of ranitidine syrup twice daily for short-term treatment. In patients who cannot remember to take a medication twice daily, this dosage can be adjusted to take 300 mg of syrup once daily after a meal. The recommended dosage for maintenance of healing duodenal ulcers is 150 mg once daily at bedtime. Patients who have GERD, hypersecretory conditions such as Zollinger-Ellison syndrome, and benign gastric ulcers should take ranitidine 150 mg twice daily.

Patients who have erosive esophagitis should take 150 mg of ranitidine four times daily. This dosage should be adjusted to 150 mg twice daily for patients who wish to maintain the healing process of erosive esophagitis.

Patients taking ranitidine in the form of efferdose tablets should take 2 to 4 mg twice per day to treat duodenal and gastric ulcers. The maximum dosage for efferdose tablets is 300 mg per day. This dosage should be adjusted to 2 to 4 mg once per day to maintain the healing process of duodenal and gastric ulcers.

All listed dosages are according to the drug manufacturer. Check your prescription and talk to your doctor to make sure you are taking the right dose for you.

Modifications

Pediatric patients wishing to treat GERD and erosive esophagitis must carefully calculate dosage based on body weight. The recommended formula is 5 to 10 mg per kilogram per day, which is usually divided into two doses.

For geriatrics or individuals with impaired kidney function, daily doses of Ranitidine should not exceed 150 mg of syrup.

How to Take and Store

One ranitidine 25 efferdose tablet should be dissolved in at least one teaspoon of water. The tablet should be fully dissolved in the water before taking it. Infants may receive efferdose tablets using a medicine dropper. One ranitidine 150 efferdose tablet should be dissolved in 6 to 8 ounces of water before drinking. This increase in fluid accommodates the increase in tablet strength.

It is acceptable to make up for missing a dose and no negative side effects should occur. However, take caution to ensure you do not exceed the maximum daily dosage in these instances.

In instances where overdosage has occurred, patients have experienced difficulty walking and a drop in blood pressure. This occurred in instances where up to 18 grams of ranitidine was taken orally.

In the event of overdosage, patients should seek medical care to remove the remaining ranitidine from their system. This will be followed by clinical monitoring and other therapies as needed.

Ranitidine efferdose tablets should be stored in an area kept between 36 F (2 C) and 86 F (30 C). Ranitidine syrup should be stored in an area kept between 39 F (4 C) and 77 F (25 C) in tight and light-resistant containers. Standard ranitidine pills should be stored in a dry, dark area kept between 60 F (15 C) and 86 F (30 C).

Side Effects

Common

Common side effects associated with taking ranitidine include dizziness, nausea, vomiting, constipation, abdominal discomfort, muscle and joint pain, and rash. When patients with impaired kidney function ingested a dose that was too high, it resulted in sedation, confusion, agitation, and hallucinations. Research has shown these symptoms were minor and easily resolved with medical care.

Severe

Severe side effects associated with taking ranitidine include irregular heart rhythms, mixed hepatitis, blood count changes (such as leukopenia, granulocytopenia, and thrombocytopenia), gynecomastia, impotence, alopecia, vasculitis, and hypersensitive reactions such as anaphylaxis and angioneurotic edema. Contact your doctor if you have any severe symptoms.

Warnings and Interactions

Ranitidine has been observed to have slight interactions with the blood-thinning medication warfarin. This has resulted in fluctuating levels of a blood test measuring prothrombin times.

Studies have been done verifying ranitidine did not harm rat and rabbit fetuses. However, these studies have not been replicated on human fetuses, making it advisable to discontinue if pregnant. Studies have shown ranitidine can have an impact on breastfeeding and should be discontinued in this case.

Ranitidine can have levels of toxic buildup in geriatric patients, those with poor kidney function, and pediatric patients. Ranitidine should be used with caution in these instances.

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