Why Am I Always Tired?

Reasons You May Feel Sleepy and Fatigued All the Time

If you feel tired all the time, you are not alone. Research estimates more than one-third of American workers are experiencing fatigue. One in five adults experiences excessive daytime sleepiness (EDS) at least three days a week.

While it may seem normal to be tired all the time in this day and age, it isn't. Fatigue that is not relieved by rest should be evaluated by a medical professional.

Fatigue—a lack of physical or mental energy—can be caused by lifestyle factors, medical conditions, sleep disorders, or mental health conditions. Chronic stress, nutritional deficiencies, depression, and sleep apnea are just a few potential reasons why you feel tired and burned out.

This article explains the potential reasons why you are always tired. It also discusses EDS symptoms, underlying causes, and treatments for fatigue that interferes with your daily life.

Verywell / Cindy Chung 

Symptoms of Excessive Sleepiness

Excessive sleepiness and sleep deprivation can have significant impacts on your health. Most of the time, fatigue is not related to a serious disease like cancer. But it can be a sign of significant health issues or be related to other risks and problems.

For example, poor quality of sleep can raise the chances that you'll fall asleep while driving. It can lead to hormonal imbalances, weight gain, or an increase in chronic pain.


Click Play to Learn What You Can Do to Feel Less Tired

This video has been medically reviewed by Chris Vincent, MD.

Poor sleep can interfere with your quality of life. Some symptoms of being sleep deprived can include:

  • Clumsiness
  • Depression
  • Difficulty learning
  • Drowsiness
  • Fatigue
  • Forgetfulness
  • Increased carbohydrate cravings
  • Irritability
  • Less interest in sex
  • Loss of motivation
  • Moodiness
  • Trouble concentrating
  • Weight gain

A night or two of poor sleep, heightened stress, or more exertion than usual can make almost anyone feel this way. When it's a constant or regular state, there is likely a cause related to:

  • Lifestyle factors
  • Common medical causes
  • Sleep disorders
  • Medication side effects

Lifestyle Factors

Different aspects of your lifestyle can have a big impact on your EDS and energy levels. Among the factors that you may want to discuss with a healthcare provider are:

  • Diet
  • Sleep habits
  • Sedentary lifestyle
  • Overexertion
  • Work schedule
  • Stress levels


Your body gets most of its energy from food. Failing to eat a balanced diet, or skipping meals, can lead to poor nutrition. This may contribute to your fatigue.

Some diet-related causes of excessive sleepiness include:

  • Vitamin and mineral deficiencies, especially of iron, vitamin B12, and vitamin D
  • Changes in your blood sugar level that limit your body's ability to transport energy to its cells
  • Excessive alcohol consumption
  • Consuming too much caffeine

Simple dietary changes and/or nutritional supplements may help to reduce your EDS and fatigue.

Poor Sleep Habits

It may seem obvious, but maybe you're just not getting enough sleep. Better sleep hygiene can help to improve the amount and quality of your sleep. These habits include:

  • Failing to get the proper amount of rest needed in your stage of life
  • Trying to sleep in an environment that's hot, noisy, or uncomfortable
  • Lacking a bedtime routine designed to help you fall asleep
  • Exercising within a few hours of bedtime
  • Napping late in the day

Choosing a better sleep routine and sleep environment may help with your fatigue symptoms.

Inactive Lifestyle

Being sedentary—not getting much physical activity—makes you more likely to have restless, poor-quality sleep. Snoring and short pauses in breathing may contribute to the problem. Other factors of inactivity that can contribute to sleep problems include:

  • Higher rates of depression
  • Increased rates of metabolic syndrome
  • Screen time and exposure to light from your devices

Research suggests that getting more physical activity can help to improve your sleep quality.

One study followed 41 people, some of whom engaged in at least 150 minutes of moderate to vigorous exercise each week for six months. Those who did reported less insomnia, depression, and anxiety than those who did not exercise.


Exercising too much or overexerting yourself in other ways can leave your body too depleted to recover overnight. This can lead you to feel tired and unmotivated or make it hard for you to sleep well. Other symptoms that can go along with overexertion include:

  • A decline in your ability to perform
  • Depression or mood swings
  • Sore, heavy limbs
  • Overuse injuries
  • Getting sick more often
  • Anxiety
  • Unintended weight loss

Cutting back on exercise, or giving yourself a week or two off to rest and recover, may eliminate your EDS and sleep problems.


Psychological stress can greatly impact how much and how well you sleep. Even worse, the lack of sleep can make you feel even more stressed. A survey of 1,950 adults by the American Psychological Association found that:

  • 43% of adults said stress had kept them awake at night in the prior month
  • 21% reported feeling more stressed after not getting enough sleep
  • Among those with higher stress levels, 45% said losing sleep increased their stress level
  • 37% reported being tired or fatigued due to stress

A 2020 study found that getting a good night's sleep helped people maintain positive emotions in the face of a stressful event and allowed them to feel more joy from positive experiences.

Lowering your stress levels or learning how to manage your stress better may help reduce your fatigue and EDS. If you're unable to do this on your own, talk to your healthcare provider.

Common Medical Causes

Fatigue, general weakness, and feeling sleepy are symptoms associated with many medical conditions. Your symptoms of EDS may be related to underlying causes that include:

These conditions affect your energy levels and lead to fatigue for different reasons. Your energy level also may be affected by your treatment, as is often the case with cancer and chemotherapy.


Anemia is a condition that causes you to have fewer red blood cells or a loss of function in those that you have. This interferes with their ability to deliver oxygen to all of the organs in your body. Common symptoms include:

  • Feeling weak or tired
  • Headaches
  • Problems concentrating or thinking
  • Irritability
  • Loss of appetite
  • Numbness and tingling of hands and feet

The most common type of anemia is caused by iron deficiency. There are other causes, ranging from inherited blood disorders and chronic illness to temporary conditions like pregnancy.

A healthcare provider can diagnose most forms of anemia through blood tests. Treatments can vary from simple changes in your diet to more serious procedures like a red blood cell transfusion.

Autoimmune Disease

In autoimmune diseases, your immune system mistakenly attacks the processes in your own body. This can lead to tissue damage and chronic inflammation. These diseases include:

These conditions often lead to fatigue. They may interfere with oxygen and nutrient supply to the body and disrupt your metabolism and nervous system. Imbalances in cytokines, which play a role in regulating mood and sleep, also may arise.

Blood tests, along with imaging such as X-rays, can help to diagnose the disorder. Treatment often includes medication to manage symptoms and better control the immune system condition.


More than 80% of people with cancer experience cancer-related fatigue. Extreme fatigue that doesn't get better with rest is often an early sign of cancer. Many factors can contribute to the fatigue and weakness of cancer, including:

  • Low blood counts or disturbed electrolytes, the key minerals in your body
  • Altered hormone levels
  • Altered cytokine and inflammation levels
  • Changes caused by cancer that affect how cells function

Cancer treatments can also cause fatigue. These treatments may include:

Your medical team should be able to help you fight your fatigue, so be sure to bring it up.

Chronic Fatigue Syndrome

Chronic fatigue syndrome (myalgic encephalomyelitis or ME/CFS) causes extreme fatigue. It doesn't get better with rest and often involves flu-like symptoms and a "brain fog" type of cognitive dysfunction.

The fatigue for people with ME/CFS gets worse even with small amounts of exertion. This leads to serious day-to-day impacts for people living with ME/CFS.

The potential causes of ME/CFS aren't known. In some people, the disease may have developed in response to infection or chronic stress. There also may be an autoimmune response involved. Research suggests a number of possible causes of fatigue in ME/CFS. They may involve:

  • Long-term infection
  • Sleep disorders and disruption
  • Cytokine problems and inflammatory activity

People are diagnosed with ME/CFS after severe, unexplained fatigue lasts for at least six months. Even then, ME/CFS is hard to pinpoint. It can take a long time to come to a diagnosis.

The disorder is treated with a drug combination of antivirals and antidepressants. Specific symptoms are treated with sleep medications and other drugs or nutritional supplements. Cognitive behavioral therapy is also a common though controversial ME/CFS treatment.

Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) causes wheezing, shortness of breath, and excess mucus in the airways. These factors can make it hard to breathe. The disease gets worse over time and is especially common in current or past smokers.

It's long been thought that difficulty breathing leads to fatigue. Some research suggests a more complex situation because fatigue doesn't always seem tied to any effort needed to breathe.

Once the link is better understood, it should become easier to manage COPD-related fatigue. For now, the primary focus is on breathing exercises and healthy lifestyle habits.


Depression is a mood disorder. It often brings feelings of sadness and loss of interest in activities, but it causes physical symptoms such as EDS and fatigue, too.

Fatigue may be due to insomnia or other sleep problems in some depressed people. Research suggests that fatigue, insomnia, and problems with concentration may be warning signs of depression.

Certain biochemical changes in depression are similar to those seen in ME/CFS. This may one day explain fatigue as a symptom of depression, but also why people with ME/CFS often have it.

Depression is typically treated with antidepressant medications. If you believe you may be depressed, it's important to talk to your healthcare provider and get proper treatment.


Fatigue is extremely common in people with diabetes. In 2018, some researchers even made a case for a new condition called "diabetes fatigue syndrome."

Possible reasons for this fatigue include:

  • Low blood sugar levels limit nutrient delivery in muscles
  • Hormonal imbalance
  • Side effects of treatment
  • Overlapping health conditions
  • Diet and other lifestyle factors

Diabetes is generally treated with medications that stabilize blood-sugar levels and/or insulin.


Fibromyalgia is a chronic pain condition. It's caused by dysfunction in the central nervous system, which heightens sensitivity and turns harmless sensations into pain or allodynia.

Fatigue and EDS are also key symptoms of fibromyalgia. This fatigue may be due to biochemical changes, inflammation, sleep disorders, and sleep disruptions.

Some of these causes are similar to those seen with ME/CFS and depression. Fibromyalgia treatment often will include antidepressant drugs, anti-seizure drugs, and low-impact exercise.

Heart Disease

If you have fatigue that's new and constant, it may be an early warning sign of heart failure or, less often, coronary artery disease. These conditions limit the amount of oxygen-rich blood that gets to your muscles or to the heart itself.

Your body needs to supply the heart and brain well. So it limits the blood sent to less key organs, such as your limbs. That leaves them with less oxygen. This will sap your energy and cause fatigue.

Other symptoms of weak heart muscles and heart failure include:

  • Shortness of breath
  • An irregular, fast, or pounding heartbeat
  • Swollen legs and feet

Treatment for heart failure usually relies on medication. These heart drugs include beta-blockers, ACE inhibitors, and diuretics that help the body to remove excess fluid. Implanted devices and surgeries also may be used, such as a defibrillator, valve replacement, or heart transplant.

Coronary artery disease involves plaques that clog your arteries. Common symptoms are the same as those for heart failure, with added chest pain or discomfort. Treatments include statin and beta-blocker drugs, angioplasty, and sometimes coronary artery bypass surgery.

Recognizing a Heart Attack

In case of a heart attack, it's important to get emergency medical help right away. You should call 9-1-1 if you or someone else has a sudden onset of any of these symptoms:

  • Chest pain or pressure; can also be felt in the upper abdomen
  • Pain that radiates to the jaw, neck, back, one or both arms, or stomach
  • Shortness of breath
  • Dizziness or fainting
  • Nausea or vomiting
  • Extreme fatigue


Fatigue frequently accompanies infectious illnesses such as:

Your fatigue may be due to an illness like this if you also have:

  • Fever
  • Diarrhea
  • Coughing
  • Muscle aches

Fatigue from infections usually clears up with the illness. Depending on the source and severity, it may be treated by antibiotics, antiviral medications, symptom management, or simply time and rest.

In some cases, though, fatigue lingers well after the illness itself is gone. This is sometimes referred to as post-viral fatigue or persistent fatigue after infection. With COVID-19, this is often called post-COVID syndrome, long COVID, or long-haul COVID.

More than half of people who've been hospitalized with COVID-19 still have fatigue several weeks after being discharged. Some researchers have begun looking into whether the coronavirus disease can lead to ME/CFS, as the long-haul symptoms are extremely similar.

The Epstein-Barr virus (EBV), which causes mono, is known to linger or reactivate later and cause fatigue, among other symptoms. It's implicated in ME/CFS and several autoimmune diseases.

Treatment for post-viral fatigue depends on the virus involved, the full range of symptoms, and what damage may have been left behind by the original illness. Common treatments are anti-viral medications and immunotherapy.


The transition to menopause, starting with perimenopause and continuing into the early post-menopausal stage, is associated with fatigue along with:

  • Hot flashes
  • Night sweats
  • Menstrual irregularities
  • Mood swings
  • Headaches
  • Cognitive problems

The fatigue of menopause may be related to sleep disruptions caused by hot flashes and night sweats. Other causes could be related to hormonal changes, aging, and stresses associated with this time of life. Some research points to a complex relationship between menopausal fatigue and stress.

Menopause isn't a disease that needs to be treated. You do have options for managing symptoms and making yourself more comfortable. They include:

  • Hormone replacement therapy (HRT)
  • SSRI antidepressants such as Paxil (paroxetine) or Effexor (venlafaxine) for hot flashes, night sweats, and mood issues
  • Exercise, including walking, swimming, and yoga


When you're pregnant, a lot of extra demands are placed on your body. This can lead to fatigue. It's most common and typically most severe in the first and third trimesters, but some people are exhausted throughout their pregnancies. Causes of pregnancy-related fatigue include:

  • Energy needed to create the placenta and nourish the baby
  • Increased metabolism
  • Hormonal changes
  • Low blood sugar
  • Low blood pressure
  • Digestive changes
  • Stress
  • Sleep disruption due to pain, needing to urinate during the night, or (later on) the baby's activity

Some research indicates that resistance-training exercise may help alleviate pregnancy fatigue. Other ways to cope with it include:

  • Getting lots of rest
  • Scaling back on activities or responsibilities
  • Eating a balanced diet
  • Staying active without pushing yourself too hard

If your fatigue suddenly increases at any point during your pregnancy, it could be a sign of trouble. Some possible causes include depression, iron-deficiency anemia, or gestational diabetes.

Symptoms to Watch For

Call your healthcare provider right away if your fatigue is accompanied by:

  • Dizziness
  • Irregular heartbeat
  • Urinating less often
  • Upper abdominal pain
  • Shortness of breath
  • Severe headaches
  • Swelling of your hands, feet, or ankles
  • Vision changes

Thyroid Disease

An imbalance of your thyroid hormones can cause EDS, and that's true whether your levels are high (hyperthyroidism) or low (hypothyroidism). Your thyroid gland, which sits at the front of your neck, produces several hormones that regulate your metabolism and have a major effect on your health.


In hyperthyroidism, all the processes in your body are sped up. This causes anxiety, a racing heart, shaking hands, unintended weight loss, and sleep problems. It can also lead to excessive sweating, which can disrupt your sleep. These sleep issues can leave you tired during the day.

Early in hyperthyroidism, you may have a lot of energy. It's not sustainable, though, and as the disease goes on, your body can become depleted and leave you fatigued.

Treatments for hyperthyroidism include:

  • Drugs such as Tapazole (methimazole) or beta blockers
  • Radioactive iodine, which lowers hormone levels by targeting hormone-producing cells
  • Surgical removal of part or all of the thyroid gland

Surgery and iodine treatments typically drop your thyroid hormone levels to low levels. This means you'll then need to take synthetic hormones to maintain a healthy level.


In hypothyroidism, all the body's processes are slowed down, and that slowdown itself causes fatigue. Other symptoms include:

  • Weight gain in spite of a decrease in appetite
  • Becoming easily chilled
  • High blood pressure
  • High cholesterol
  • Dry skin and brittle nails
  • Concentration and memory problems
  • Loss of interest in things you used to care about

Hypothyroidism is treated with synthetic thyroid hormones.

Graves' and Hashimoto's

Two autoimmune diseases can strike the thyroid gland: Graves' disease, which is a type of hyperthyroidism, and Hashimoto's disease, which is a type of hypothyroidism. The autoimmune and inflammatory aspects of these conditions can cause additional fatigue.

Sleep Disorders

Excessive daytime sleepiness and fatigue are the primary symptoms of sleep disorders. These disorders may include:

If your healthcare provider suspects you have a sleep disorder, they may ask you to keep a log of how long and how well you sleep. They may send you for a sleep study, called a polysomnography. Many sleep disorders can be successfully treated once they're identified.

Circadian Rhythm Disorders

Various circadian rhythm disorders can leave you feeling too sleepy during the day. The circadian rhythm is your body's natural clock and it helps to coordinate your activities based on when it's light and dark in your environment. If your internal timing is misaligned, you may find yourself with excessive daytime sleepiness. Six common circadian rhythm disorders are:

  • Advanced sleep phase syndrome: The distinguishing feature is falling asleep and waking up earlier than you want, usually by about 3 hours.
  • Delayed sleep phase syndrome: Similar to insomnia, this causes difficulty falling asleep and makes it extremely hard to wake up.
  • Irregular sleep-wake rhythm: Occurs when the circadian rhythm becomes completely disconnected from the natural day-night cycle. Sleep is fragmented, with short spells scattered throughout the day.
  • Jet lag: A temporary rhythm disorder associated with travel across several time zones. To adjust, it may take one day for every time zone you crossed.
  • Non-entrained (non-24) disorder: This usually occurs in visually impaired people. The sleep cycle is typically a little longer than average and thus becomes more out of sync every day.
  • Shift-work sleep disorder: Poor sleep is caused by working at night and sleeping during the day. This can lead to increased accidents and possibly a higher risk of some forms of cancer.

Effective treatments for circadian rhythm disorders include light therapy, melatonin, sedatives or stimulant medications, and behavioral changes that improve your sleep habits.


Probably the best-known sleep disorder, insomnia can make it hard for you to fall asleep, stay asleep, or get quality sleep. Just about everyone has an occasional bout of insomnia. For some, it's a chronic problem that leaves them with EDS and fatigue.

Insomnia can be caused by a combination of factors. They include:

  • Genetics
  • Environment
  • Working at odd hours or keeping an unusual sleep schedule
  • Caffeine, nicotine, and other use of stimulants
  • Alcohol and other depressants
  • Illegal drugs
  • Being sedentary
  • High stress levels
  • Too much light exposure (such as from screens) close to bedtime

Treatments for insomnia include:

  • Cognitive behavioral therapy to improve sleep habits
  • Lifestyle changes
  • Sedative medications
  • Light therapy

Kleine-Levin Syndrome

Although quite rare, Kleine-Levin syndrome is a condition that may affect young adults, especially men. It can cause recurrent episodes of excessive sleepiness. These episodes can last for days, weeks, or even months at a time. The level of being tired can be incapacitating.

This syndrome often interferes with school attendance and basic daily functions. Some of the symptoms may include:

  • Hallucinations
  • Hypersexual or compulsive behaviors
  • Binge eating
  • Cognitive and mood disturbances

The only treatments thought to be beneficial in Kleine-Levin syndrome are lithium and carbamazepine to help shorten episodes, and stimulants to alleviate EDS.


In narcolepsy, the body is unable to regulate its sleep patterns. Sleep may suddenly occur when you're awake while elements of wakefulness may interrupt sleep. Narcolepsy is best known for attacks of EDS that may cause you to doze off for short periods at unexpected times.

Another major symptom of narcolepsy is cataplexy. This is the sudden loss of voluntary muscle control often associated with an emotional response such as surprise or laughter. In a mild instance, your knees may buckle or your jaw will hang open. A more severe episode means you may collapse onto the floor and be unable to move for several minutes.

Other symptoms of narcolepsy include:

  • Vivid and often alarming hallucinations while falling asleep or waking up
  • Recurring episodes of sleep paralysis, with the sense you are unable to move
  • Frequent awakenings at night
  • Routine actions done during sleep attacks but with no memory of it afterward

The EDS associated with narcolepsy is sometimes treated with stimulants, such as:

  • Ritalin
  • Provigil
  • Nuvigil

The drug Xyrem (sodium oxybate) treats both EDS and cataplexy. Tricyclic antidepressants and SSRIs may help with cataplexy, hallucinations, sleep paralysis, and overnight sleep disruptions.

Restless Legs Syndrome

Disorders that cause excessive movements during sleep can disrupt your sleep and leave you tired the next day. The most common of these conditions is restless legs syndrome (RLS).

This disorder is known by an uncomfortable sensation in the legs coupled with the urge to move. It often develops in the evening as you are lying down to rest and is relieved when you move.

A related condition called periodic limb movement syndrome (PLMS) involves sudden jerking movements that occur during sleep. These may be repetitive, disturbing your sleep and potentially that of your bed partner.

Drugs commonly prescribed for RLS include:

  • Anti-seizure medications: Neurontin (gabapentin), Lyrica (pregabalin)
  • Dopamine agonists: Requip (ropinirole), Mirapex (pramipexole), Neupro patch (rotigotine)
  • Benzodiazepines: Klonopin (clonazepam) in severe cases

Other treatments may include:

  • Regular exercise
  • Good sleep habits
  • Avoiding caffeine
  • Using heat, cold, or massage to relieve leg discomfort
  • Massage, acupuncture, or relaxation techniques
  • Stress reduction or management
  • Iron supplements

Sleep Apnea

Sleep apnea is a condition in which your breathing pauses partially or completely while you sleep. It can occur dozens of times an hour or even hundreds of times a night. It's common for these pauses to be followed by a loud snort and brief awakening as you gasp for air.

With each episode, you shift briefly into lighter stages of sleep. You may wake completely and fall back asleep without even remembering it. The frequently disrupted sleep leaves you with EDS and its associated symptoms. Other symptoms of sleep apnea include:

  • Snoring
  • Dry mouth and sore throat in the morning
  • Teeth grinding (bruxism)
  • Morning headaches
  • Sexual dysfunction
  • Frequent nighttime urination

Treatment for sleep apnea includes:

  • Using a CPAP (continuous positive airway pressure) machine or other types of PAP while sleeping
  • Dental devices
  • Surgery to correct problems that interfere with breathing, such as large tonsils, unusually small jaw and overbite, or a deviated nasal septum

Warning: Risk of Fatal Complications

Sleep apnea puts a strain on your heart. It can lead to high blood pressure, cardiomyopathy (enlarged muscle tissue in the heart), heart failure, heart attack, and stroke. This makes proper diagnosis and treatment of sleep apnea especially important.

Medications That Cause Drowsiness

Drowsiness, EDS, and fatigue are common side effects of medications. Your healthcare provider will likely look into what medications you're taking if you frequently have fatigue. Drugs that can make you tired include:


Fatigue and tiredness are common symptoms of many illnesses. In some cases, fatigue may arise from a condition such as diabetes, heart disease, or an autoimmune disorder. In others, such as cancer, the fatigue and EDS can be caused by both the disease and its treatments.

Many cases of fatigue and EDS are related to specific sleep disorders, which can interfere with the amount or quality of sleep, or conditions such as chronic fatigue syndrome.

Start by talking to your healthcare provider. A routine physical can identify many treatable causes of fatigue, such as iron or vitamin D deficiencies, thyroid disorders, and diabetes. A sleep study can rule out a sleep disorder.

Lifestyle changes such as eating more fruits and vegetables, getting moderate exercise, and practicing good sleep hygiene can ease daytime sleepiness. When more is needed, there are treatment options for EDS to help get you back on track.

Frequently Asked Questions

  • Why am I so tired when I wake up after 8 hours of sleep?

    Feeling tired when you first wake up is known as sleep inertia. It usually lasts between 15 minutes and one hour. If you are getting solid sleep but still unable to shake that sleepy feeling, it could be a sleep disorder, medical condition, or lifestyle factor. 

  • What should I do if I am constantly tired?

    If you feel tired all the time, make an appointment to see your healthcare provider. Excessive fatigue can be a sign of an underlying medical condition. Getting an appropriate diagnosis and treatment can help to restore normal energy levels.

  • How can I boost my energy?

    Finding and treating the underlying cause of your fatigue is the best way to restore your energy. In the short term, make sure you are drinking enough water and eating enough nutritious food. Limit your alcohol intake.

    Try to avoid reaching for sugar and caffeine—both may provide a temporary energy boost that leaves you more tired when the jolt fades. Fresh air, sunlight, and physical activity can also lessen fatigue. 

  • How many hours of sleep is normal?

    Adults ages 18 to 60 should get at least 7 hours of sleep a night. Some people require a little more sleep to feel well rested, while others need less. If you are sleeping 8 or 9 hours a night and still not feeling rested, speak to your healthcare provider.

  • Can COVID cause fatigue?

    Yes, in more ways than one. First, fatigue is a symptom of COVID. Once you are past the acute infection, fatigue can last for several weeks and sometimes months.

    For people who have not had the virus, COVID can cause fatigue in another way. The stress of living during a pandemic and the many lifestyle changes that accompanied it is exhausting for many people.

    In addition, social isolation, boredom, and disappointment in canceled events can exacerbate mental health conditions like depression, which also cause fatigue.

45 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Junghaenel DU, Christodoulou C, Lai JS, Stone AA. Demographic correlates of fatigue in the US general population: results from the patient-reported outcomes measurement information system (PROMIS) initiative. J Psychosom Res. 2011;71(3):117-23. doi:10.1016/j.jpsychores.2011.04.007

  2. Brown J, Makker HK. An approach to excessive daytime sleepiness in adultsBMJ 2020;368:m1047. doi: 10.1136/bmj.m1047

  3. Lindell M, Grimby-Ekman A. Stress, non-restorative sleep, and physical inactivity as risk factors for chronic pain in young adults: A cohort study. Almeida A, ed. PLoS ONE. 2022;17(1):e0262601. doi: 10.1371/journal.pone.0262601

  4. Harvard Medical School. Harvard Health Publishing. Could a vitamin or mineral deficiency be behind your fatigue?

  5. National Institutes of Health, National Institute on Aging. Fatigue in older adults.

  6. Pengpid S, Peltzer K. Sedentary behaviour and 12 sleep problem indicators among middle-aged and elderly adults in South AfricaInt J Environ Res Public Health. 2019;16(8):1422. Published 2019 Apr 20. doi:10.3390/ijerph16081422

  7. Hartescu I, Morgan K, Stevinson CD. Increased physical activity improves sleep and mood outcomes in inactive people with insomnia: A randomized controlled trialJ Sleep Res. 2015;24(5):526-534. doi:10.1111/jsr.12297

  8. National Institutes of Health, U.S. National Library of Medicine: MedlinePlus. Are you getting too much exercise?

  9. American Psychological Association. Stress and sleep.

  10. Sin NL, Wen JH, Klaiber P, Buxton OM, Almeida DM. Sleep duration and affective reactivity to stressors and positive events in daily lifeHealth Psychol. 2020; doi:10.1037/hea0001033

  11. University of Pennsylvania. Penn Medicine. What Is Anemia?

  12. Zielinski MR, Systrom DM, Rose NR. Fatigue, sleep, and autoimmune and related disordersFront Immunol. 2019;10:1827. doi:10.3389/fimmu.2019.01827

  13. American Cancer Society. What is fatigue or weakness?

  14. Sotzny F, Blanco J, Capelli E, et al. Myalgic encephalomyelitis/chronic fatigue syndrome - Evidence for an autoimmune diseaseAutoimmun Rev. 2018;17(6):601-609. doi:10.1016/j.autrev.2018.01.009

  15. Montoya JG, Holmes TH, Anderson JN, et al. Cytokine signature associated with disease severity in chronic fatigue syndrome patients. Proc Natl Acad Sci USA. 2017;114(34):E7150-E7158. doi:10.1073/pnas.1710519114

  16. Goërtz YMJ, Spruit MA, Van 't Hul AJ, et al. Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitationTher Adv Respir Dis. 2019;13:1753466619878128. doi:10.1177/1753466619878128

  17. Goërtz YMJ, Looijmans M, Prins JB, et al. Fatigue in patients with chronic obstructive pulmonary disease: Protocol of the Dutch multicentre, longitudinal, observational FAntasTIGUE studyBMJ Open. 2018;8(4):e021745. doi:10.1136/bmjopen-2018-021745

  18. Corfield EC, Martin NG, Nyholt DR. Co-occurrence and symptomatology of fatigue and depressionCompr Psychiatry. 2016;71:1-10. doi:10.1016/j.comppsych.2016.08.004

  19. Allen J, Romay-Tallon R, Brymer KJ, Caruncho HJ, Kalynchuk LE. Mitochondria and mood: Mitochondrial dysfunction as a key player in the manifestation of depressionFront Neurosci. 2018;12:386. doi:10.3389/fnins.2018.00386

  20. Kalra S, Sahay R. Diabetes fatigue syndromeDiabetes Ther. 2018;9(4):1421-1429. doi:10.1007/s13300-018-0453-x

  21. Littlejohn G, Guymer E. Key milestones contributing to the understanding of the mechanisms underlying fibromyalgiaBiomedicines. 2020;8(7):223. doi:10.3390/biomedicines8070223

  22. Keskindag B, Karaaziz M. The association between pain and sleep in fibromyalgiaSaudi Med J. 2017;38(5):465-475. doi:10.15537/smj.2017.5.17864

  23. Harvard Medical School, Harvard Health Publishing. 5 overlooked symptoms that may signal heart trouble.

  24. Halpin SJ, McIvor C, Whyatt G, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluationJ Med Virol. 2021;93(2):1013-1022. doi:10.1002/jmv.26368

  25. Wostyn P. COVID-19 and chronic fatigue syndrome: Is the worst yet to come?Med Hypotheses. 2021;146:110469. doi:10.1016/j.mehy.2020.110469

  26. Kerr JR. Epstein-Barr virus (EBV) reactivation and therapeutic inhibitorsJ Clin Pathol. 2019;72(10):651-658. doi:10.1136/jclinpath-2019-205822

  27. Taylor-Swanson L, Wong AE, Pincus D, et al. The dynamics of stress and fatigue across menopause: Attractors, coupling, and resilienceMenopause. 2018;25(4):380-390. doi:10.1097/GME.0000000000001025

  28. Harvard Medical School, Harvard Health Publishing. Dealing with the symptoms of menopause.

  29. American Pregnancy Association. Fatigue during pregnancy.

  30. OʼConnor PJ, Poudevigne MS, Johnson KE, Brito de Araujo J, Ward-Ritacco CL. Effects of resistance training on fatigue-related domains of quality of life and mood during pregnancy: A randomized trial in pregnant women with increased risk of back painPsychosom Med. 2018;80(3):327-332. doi:10.1097/PSY.0000000000000559

  31. Sanford Health. 8 warning signs during pregnancy.

  32. American Thyroid Association. Hyperthyroidism.

  33. Harvard Medical School, Harvard Health Publishing. The lowdown on thyroid slowdown.

  34. National Institutes of Health, National Heart, Lung, and Blood Institute. Circadian rhythm disorders.

  35. National Institutes of Health, National Heart, Lung, and Blood Institute. Insomnia.

  36. de Oliveira MM, Conti C, Prado GF. Pharmacological treatment for Kleine-Levin syndromeCochrane Database Syst Rev. 2016;2016(5):CD006685. doi:10.1002/14651858.CD006685.pub4

  37. Stanford University, Stanford Health Care. Treatments for Kleine-Levin syndrome.

  38. National Organization for Rare Disorders. Narcolepsy.

  39. Abad VC, Guilleminault C. New developments in the management of narcolepsy. Nat Sci Sleep. 2017(9):39-57. doi:10.2147/NSS.S103467

  40. Koo BB, Bagai K, Walters AS. Restless legs syndrome: Current concepts about disease pathophysiology. Tremor Other Hyperkinet Mov (N Y). 2016;6:401. doi:10.7916/D83J3D2G

  41. Raheem OA, Orosco RK, Davidson TM, Lakin C. Clinical predictors of nocturia in the sleep apnea population. Urol Ann. 2014;6(1):31-5. doi:10.4103/0974-7796.127019

  42. Harvard Medical School, Harvard Health Publishing. What to do when medication makes you sleepy.

  43. Centers for Disease Control and Prevention. How much sleep do I need?

  44. Mayo Clinic. COVID-19: Long-term effects.

  45. Mental Health America. Mental health challenges and fatigue during COVID-19.

By Brandon Peters, MD
Brandon Peters, MD, is a board-certified neurologist and sleep medicine specialist.